{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:38:15Z","timestamp":1765600695252,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:p>The effect of a long-term treatment (one to two years) with cimetidine (1.6 g per day) and an antacid (Regla pH) was evaluated in nine patients with a Barrett's oesophagus. The results showed that such long-term treatment had a beneficial effect on the symptoms and endoscopic signs of oesophagitis and on the healing of a Barrett's ulcer, but did not result in a regression of the squamocolumnar junction back towards the cardia. No significant changes were observed in the histological epithelial types in the biopsies taken below the squamocolumnar junction. No clinical or biochemical side-effects or changes in biochemical parameters were noted during this study.<\/jats:p>","DOI":"10.1136\/gut.22.9.724","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"724-727","source":"Crossref","is-referenced-by-count":68,"title":["Effect of long-term treatment with cimetidine and antacids in Barrett's oesophagus."],"prefix":"10.1136","volume":"22","author":[{"given":"I C","family":"Wesdorp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bartelsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G N","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,9,1]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Barrett's csophagus: congenital or acquired? An cxpcrimcintal stud(l of esophageal mucosal rcgenerationi in thc (log. Surgery","volume":"68","author":"Bremner, C.G.; Lynch, V.P.; Ellis, F.H.","year":"1970","unstructured":"Bremner CG, Lynch VP, Ellis FH. Barrett's csophagus: congenital or acquired? An cxpcrimcintal stud(l of esophageal mucosal rcgenerationi in thc (log. Surgery 1970; 68:209-16."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0016-5085(66)80127-0","article-title":"The columinar-linied cophagns (B3arrett's syndrome): an acquircd condition?","volume":"50","author":"Mossberg, S.M.","year":"1966","unstructured":"Mossberg SM. The columinar-linied cophagns (B3arrett's syndrome): an acquircd condition? Ga.stroenterology 1966; 50:671-6.","journal-title":"Ga.stroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5223(19)39666-7","article-title":"Coluimnar-lincd lower esophagLis: ani acquired lesion with malignant predisposition","volume":"70","author":"Naef, A.P.; Savary, M.; Oziello, L.","year":"1975","unstructured":"Naef AP, Savary M, Oziello L. Coluimnar-lincd lower esophagLis: ani acquired lesion with malignant predisposition. J Thor Cardil'ota.%e Surg 1975; 70: 826-35.","journal-title":"J Thor Cardil'ota.%e Surg"},{"issue":"511 4","key":"ref_4","article-title":"Adeniocaircitionoma in the colinmnar epithelill lined lox\\er (Barrett) esophagus","volume":"28","author":"LH, Hasswe A.Paine W.S.Weiland","year":"1973","unstructured":"Hasswe A. Paine WS. Weiland LH. Adeniocaircitionoma in the colinmnar epithelill lined lox\\er (Barrett) esophagus. Ihorax 1973; 28:511 4. -NMcDoalKld Cil. Brandl DL. Thornling DR. Multiple adenomaitous ineoplisms arisin in columiinar (Barrett's) esophagus. (a,%stroetttrologi. 1977; 72: 1317 21.","journal-title":"Ihorax; NMcDoalKld Cil. Brandl DL. Thornling DR. Multiple adenomaitous ineoplisms arisin in columiinar (Barrett's) esophagus"},{"issue":"844 8","key":"ref_5","article-title":"Selx yn J1. Primiarv aideniocaircillnomla of the esophagus arising in a columnar-lined esophaguFs","volume":"302","author":"IStillmanii, A.L.","year":"1975","unstructured":"IStillmanii AL, Selx yn J1. Primiarv aideniocaircillnomla of the esophagus arising in a columnar-lined esophaguFs. Am J Dig Dis 1975; 20:577-82. 71rand l)LD Ylvisaker JTh. (ielfand( NI. Pope C1 11. Regrcssioin of columlnar esophageal (B1a1rrett's) epithelium after anti-reflux surgery. N' Enl J AMled 1980; 302:844 8.","journal-title":"Am J Dig Dis; 20: 577-82. 71rand l)LD Ylvisaker JTh. (ielfand( NI. Pope C1 11. Regrcssioin of columlnar esophageal (B1a1rrett's) epithelium after anti-reflux surgery. N"},{"issue":"476 81","key":"ref_6","article-title":"Oral cimetidine in reflux esophagitis: a (lol0ble blin(l controlled trial","volume":"295","author":"SWesdorp, E.; Bartelsman, J.; Pape, K.; Dekker, W.; Tvtgat, C.N.","year":"1978","unstructured":"SWesdorp E, Bartelsman J, Pape K, Dekker W, Tvtgat CN. Oral cimetidine in reflux esophagitis: a (lol0ble blin(l controlled trial. (;Gatro(enltero1logy 1978; 74:'21 4. llaull A. Trier JS. D)altouNMi). Camnp RC, l oeb P), Gioxal RK. '[he histological spectrium of' Barrett's esopchagus..\\ fligi J 'Wed 1976; 295:476 81). Radttiea 1R, (ilover JIL Shipley F. Slhoemnaker","journal-title":"Barrett's esopchagus..\\ fligi J 'Wed; 74: '21 4. llaull A. Trier JS. D)altouNMi). Camnp RC, l oeb P), Gioxal RK. '[he histological spectrium of"},{"issue":"486 91","key":"ref_7","volume":"112","author":"esoplhaLgu, R.I.Barrett","year":"1977","unstructured":"RI Barrett esoplhaLgu. Ar(li Surg 1977; 112:486 91.","journal-title":"Ar(li Surg"},{"issue":"441 8","key":"ref_8","article-title":"Brand l)l.. lBros\\xn FC, et ul. ('imeti(dinie in thle treatment of s!\\pmtomat)itic gaitr)ceoplhalge, cal reflux","volume":"74","author":"Bllehatr, J.","year":"1978","unstructured":"Bllehatr J, Brand l)l.. lBros\\xn FC, et ul. ('imeti(dinie in thle treatment of s!\\pmtomat)itic gaitr)ceoplhalge,cal reflux. (;astro(f,it('rol)h,t,\\ 1978; 74:441 8."},{"key":"ref_9","first-page":"81","article-title":"Barr R lharmacot herapy of ain uilcer in Barrett's soprlia: ca.rbexloxaloc alnd cinmeti(linie. (; cz tuIugO'","volume":"73","author":"i ranlt lVhompson W","year":"1977","unstructured":"( i ranlt lVhompson W.Barr R lharmacot herapy of ain uilcer in Barrett's soprlia: ca.rbexloxaloc alnd cinmeti(linie. (;cz tuIugO' 1977; 73:81)8 10).:Kothlri r NiManglaIJC Kalra T1M1S. Barrett's ulcer and treatment with cimetidine. Arrch Intern Med 1980; 140:475-7.","journal-title":"Arrch Intern Med; 10).: Kothlri r NiManglaIJC Kalra T1M1S. Barrett's ulcer and treatment with cimetidine"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.22.9.724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:36:03Z","timestamp":1765600563000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.22.9.724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1981,9,1]]},"published-print":{"date-parts":[[1981,9]]}},"alternative-id":["10.1136\/gut.22.9.724"],"URL":"https:\/\/doi.org\/10.1136\/gut.22.9.724","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}