{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:59:11Z","timestamp":1765666751725,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:p>Twenty-nine adult patients with coeliac disease and 39 patients with a normal duodenal morphology were studied with respect to the 5-ht containing enterochromaffin cells. Their number in duodenal biopsies was assessed by fluorescence histochemistry and they were examined by immunohistochemistry for peptides known or believed to occur in enterochromaffin cells. Antisera used were raised against substance P, motilin, and leu-enkephalin. In addition, the concentration of 5-HT was determined chemically. In adult coeliac disease there was a significant increase in the number of duodenal enterochromaffin cells compared with the control group. The concentration of 5-HT in the duodenal mucosa was also greatly increased. Substance P was found in a minority population of enterochromaffin cells. These cells were very few and did not increase in number in coeliac disease. Motilin cells were distinct from enterochromaffin cells. No enkephalin immunoreactive cells were found in the biopsies.<\/jats:p>","DOI":"10.1136\/gut.23.1.42","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"42-48","source":"Crossref","is-referenced-by-count":41,"title":["Enteropathy of coeliac disease in adults: increased number of enterochromaffin cells the duodenal mucosa."],"prefix":"10.1136","volume":"23","author":[{"given":"K","family":"Sj\u00f6lund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Alumets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N O","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"H\u00e5kanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sundler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"key":"ref_1","first-page":"\"217","article-title":"and 5-HT in granules isolated from intestinal argentaffin carcinoid","volume":"52","author":"Alumets, J.; HAkanson, R.; Ingemansson, S.; Substance, Sundler F.; P.","year":"1977","unstructured":"Alumets J, HAkanson R, Ingemansson S, Sundler F. Substance P and 5-HT in granules isolated from intestinal argentaffin carcinoid. Histochemistry 1977; 52:217-22. 2Heitz Ph, Polak JM, Timson CM, Pearse AGE. Enterochromaffin cells as the endocrine source of gastrointestinal substance P. Histochemistry 1976; 49:343-7.","journal-title":"Histochemistry; Enterochromaffin cells as the endocrine source of gastrointestinal substance P"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00490158","article-title":"Localization of substance P-like immunoreactivity in mouse gut","volume":"43","author":"Nilsson, G.; Larsson, L.-I.; HAkanson, R.; Brodin, E.; Pernow, B.; Sundler, F.","year":"1975","unstructured":"Nilsson G, Larsson L-I, HAkanson R, Brodin E, Pernow B, Sundler F. Localization of substance P-like immunoreactivity in mouse gut. Histochemistry 1975; 43:97-9.","journal-title":"Histochemistry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF00490081","article-title":"Immunocytochemical localization of substance P in mammalian intestine","volume":"41","author":"Pearse, A.G.E.; Polak, J.M.","year":"1975","unstructured":"Pearse AGE, Polak JM. Immunocytochemical localization of substance P in mammalian intestine. Histochemistry 1975; 41:373-5.","journal-title":"Histochemistry"},{"key":"ref_4","first-page":"121","article-title":"5-Hydroxytryptaminecontaining enterochromaffin cells: storage site ofsubstance P","volume":"452","author":"Sundler, F.; Alumets, J.; Hakanson, R.","year":"1977","unstructured":"Sundler F, Alumets J, Hakanson R. 5-Hydroxytryptaminecontaining enterochromaffin cells: storage site ofsubstance P. Acta Physiol Scand (Suppl) 1977; 452:121-3.","journal-title":"Acta Physiol Scand (Suppl)"},{"key":"ref_5","first-page":"59","article-title":"Substance P in the gut: immunochemical and immunohistochemical study of its distribution and development","author":"Sundler, F.; Hakanson, R.; Larsson, L.-I.; Brodin, E.; Nilsson, G.","year":"1977","unstructured":"Sundler F, Hakanson R, Larsson L-I, Brodin E, Nilsson G. Substance P in the gut: immunochemical and immunohistochemical study of its distribution and development. In: von Euler US, Pernow B, eds. Substance P. New York: Raven Press, 1977:59-65."},{"key":"ref_6","first-page":"\"187","article-title":"Leuenkephalin-like material in nerves and enterochromaffin cells in the gut","volume":"56","author":"Alumets, J.; Hakanson, R.; Sundler, F.; Chang, K.-J.","year":"1978","unstructured":"Alumets J, Hakanson R, Sundler F, Chang K-J. Leuenkephalin-like material in nerves and enterochromaffin cells in the gut. Histochemistry 1978; 56:187-96. 8Heitz Ph, Kasper M, Krey G, Polak JM, Pearse AGE. Immunoelectroncytochemical localization of motilin in human duodenal enterochromaffin cells. Gastroenterology 1978; 74:713-7.","journal-title":"Histochemistry; Immunoelectroncytochemical localization of motilin in human duodenal enterochromaffin cells. Gastroenterology 1978; 74"},{"key":"ref_7","first-page":"35","article-title":"The cellular origin of motilin in the gastrointestinal tract","volume":"11","author":"Pearse, A.G.E.","year":"1976","unstructured":"Pearse AGE. The cellular origin of motilin in the gastrointestinal tract. Scand J Gastroenterol 11 (Suppl) 1976; 39:35-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","first-page":"\"111","article-title":"Enterochromaffin cells of the mammalian small intestine as the source of motilin","volume":"16","author":"Pearse, A.G.E.; Polak, J.M.; Bloom, SR, Adams; C, JR, Dryburgh; Brown, J.C.","year":"1974","unstructured":"Pearse AGE, Polak JM, Bloom SR, Adams C, Dryburgh JR, Brown JC. Enterochromaffin cells of the mammalian small intestine as the source of motilin. VirchovsArch B Cell Pathol 1974; 16:111-20. 1tPolak JM, Buchan AMJ, Dryburgh JR, Christofides N, Bloom SR, Yanaihara N. Immunoreactive motilins. Lancet 1978; 1:1364.","journal-title":"VirchovsArch B Cell Pathol; Immunoreactive motilins"},{"key":"ref_9","first-page":"39","article-title":"Differential localization of substance P and motilin","volume":"11","author":"Polak, J.M.; Ph, Heitz; Pearse, A.G.E.","year":"1976","unstructured":"Polak JM, Heitz Ph, Pearse AGE. Differential localization of substance P and motilin. Scand J Gastroenterol 11 (Suppl) 1976; 39:39-42.","journal-title":"Scand J Gastroenterol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.16.3.225","article-title":"Complete identification of endocrine cells in the gastrointestinal tract using semithin sections to identify motilin cells in human and animal intestine","volume":"16","author":"Polak, J.M.; Pearse, A.G.E.; Heath, C.M.","year":"1975","unstructured":"Polak JM, Pearse AGE, Heath CM. Complete identification of endocrine cells in the gastrointestinal tract using semithin sections to identify motilin cells in human and animal intestine. Gut 1975; 16:225-9.","journal-title":"Gut"},{"key":"ref_11","first-page":"43","article-title":"Differential demonstration of the motilin cell and the enterochromaffin cell","volume":"11","author":"Forssman, W.G.; Yanaihara, N.; Helmstaedter, V.; Grube, D.","year":"1976","unstructured":"Forssman WG, Yanaihara N, Helmstaedter V, Grube D. Differential demonstration of the motilin cell and the enterochromaffin cell. Scand J Gastroenterol 11 (Suppl) 1976; 39:43-5.","journal-title":"Scand J Gastroenterol"},{"key":"ref_12","first-page":"897","article-title":"Immunohistochemical localization of motilin in endocrine nonenterochromaffin cells ofthe small intestine","volume-title":"of humans and monkey. Gastroenterology 1979","volume":"76","author":"Helmstaedter, V.; Kreppein, W.; Domschke, W.; Mitznegg, P.; Yanaihara, N.; Wiinsch, E.; Forssmann, W.G.","unstructured":"Helmstaedter V, Kreppein W, Domschke W, Mitznegg P, Yanaihara N, Wiinsch E, Forssmann WG. 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Presence of substance P-like immunoreactivity in plasma from man and dog. Acta Physiol Scand 1975; 94:542-4.","journal-title":"Acta Physiol Scand"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.23.1.42","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:57:13Z","timestamp":1757275033000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.23.1.42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1982,1,1]]},"published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1136\/gut.23.1.42"],"URL":"https:\/\/doi.org\/10.1136\/gut.23.1.42","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}