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An additional finding was that men who were cigarette smokers had significantly lower concentrations of fundic mucosal histamine (but not HMT) than non-smokers and, as there was an excess of cigarette smokers among patients with duodenal ulcer, this may be the explanation for the reduced concentrations of fundic mucosal histamine in these patients.<\/jats:p>","DOI":"10.1136\/gut.23.1.58","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"58-62","source":"Crossref","is-referenced-by-count":23,"title":["Gastric mucosal histamine and histamine methytltransferase in patients with duodenal ulcer."],"prefix":"10.1136","volume":"23","author":[{"given":"N R","family":"Peden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Callachan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K G","family":"Wormsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"issue":"178","key":"ref_1","first-page":"214","volume":"1920","author":"Popielski J., -imidazolylathylamin und die Organextrakte I","unstructured":"Popielski J.,-imidazolylathylamin und die Organextrakte I. Pflugers Archiv 1920; 178:214-36.","journal-title":"Pflugers Archiv"},{"key":"ref_2","first-page":"\"385","article-title":"Definition and antagonism of histamine H2-receptors","volume":"236","author":"Black, J.W.; Durant, C.J.; Ganellin, C.R.; Parsons, E.M.","year":"1972","unstructured":"Black JW, Durant CJ, Ganellin CR, Parsons EM. Definition and antagonism of histamine H2-receptors. Nature 1972; 236:385-90. 3A multicentre trial. Treatment of duodenal ulcer by metiamide. Lancet 1975; 779-81.","journal-title":"Nature; multicentre trial. Treatment of duodenal ulcer by metiamide"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/BF01469008","article-title":"Histamine and peptic ulcer: a prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases","volume":"54","author":"Troidl, H.; Lorenz, W.; Rohde, H.; Hafner, G.; Ronzheimer, M.","year":"1976","unstructured":"Troidl H, Lorenz W, Rohde H, Hafner G, Ronzheimer M. Histamine and peptic ulcer: a prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases. Klin Wschr 1976; 54:947-56.","journal-title":"Klin Wschr"},{"key":"ref_4","first-page":"444","article-title":"Gastric mucosal histamine in duodenal ulcer patients: release by secretin","volume":"24","author":"Domschke, W.; Subramanian, N.; Mitznegg, P.; Baenkler, H.W.; Domschke, S.; Wunsch, E.","year":"1977","unstructured":"Domschke W, Subramanian N, Mitznegg P, Baenkler HW, Domschke S, Wunsch E. Gastric mucosal histamine in duodenal ulcer patients: release by secretin. Acta Hepato-Gastroenterol 1977; 24:444-6.","journal-title":"Acta Hepato-Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0009-8981(72)90419-6","article-title":"Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues","volume":"37","author":"Beaven, M.A.; Jacobsen, S.; Horakova, Z.","year":"1972","unstructured":"Beaven MA, Jacobsen S, Horakova Z. Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues. Clin Chim Acta 1972; 37:91-103.","journal-title":"Clin Chim Acta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry, O.H.; Rosebrough, N.H.; Farr, A.L.; Randall, R.J.","year":"1951","unstructured":"Lowry OH, Rosebrough NH, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.","journal-title":"J Biol Chem"},{"key":"ref_7","first-page":"182","article-title":"A method for the fluorometric assay of histamine in tissues","volume":"127","author":"Shore, P.A.; Burkhalter, A.; Eohn, V.H.","year":"1959","unstructured":"Shore PA, Burkhalter A, Eohn VH. A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther 1959; 127:182-6.","journal-title":"J Pharmacol Exp Ther"},{"key":"ref_8","series-title":"Proceedings of an international symposium on histamine H2-receptor antagonists. Amsterdam: Excerpta Medica","volume":"6","author":"Lorenz, W.","year":"1978","unstructured":"Lorenz W, Troidl H, Barth H, Rohde H. In: Ereutzfeldt W, ed. Proceedings of an international symposium on histamine H2-receptor antagonists. Amsterdam: Excerpta Medica, 1978; P6."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01964884","article-title":"Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment","volume":"7","author":"Barth, H.; Troidl, H.; Lorenz, W.; Rohde, H.; Glass, R.","year":"1977","unstructured":"Barth H, Troidl H, Lorenz W, Rohde H, Glass R. Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment. Agents Actions 1977; 7:75-9.","journal-title":"Agents Actions"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.23.1.58","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:16:41Z","timestamp":1765635401000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.23.1.58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1982,1,1]]},"published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1136\/gut.23.1.58"],"URL":"https:\/\/doi.org\/10.1136\/gut.23.1.58","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}