{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:49:13Z","timestamp":1768448953191,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:p>Gastro-oesophageal reflux has been assessed in 10 symptomatic patients and 10 asymptomatic normal subjects during a study period of 24 hours at work and in the home using a newly developed pH sensitive radiotelemetry capsule and a portable receiving system. Oesophageal pH was continuously monitored by the tethered radiotelemetry capsule and recorded with a portable receiver and a 24-hour cassette recorder, allowing the patient complete freedom of movement so that ambulatory studies could be undertaken during a normal working day. The number and duration of reflux episodes was greater in symptomatic patients than normal subjects during 24-hour studies at home (p less than 0.002). In both groups, reflux occurred more during the day than at night (p less than 0.01). Patients refluxed significantly more at home than when they were in hospital (p less than 0.01). Ambulatory outpatient oesophageal pH monitoring may be useful in the management of patients with atypical symptoms and may demonstrate significant reflux when inpatient investigations and endoscopy findings show minimal abnormality.<\/jats:p>","DOI":"10.1136\/gut.23.11.992","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"992-998","source":"Crossref","is-referenced-by-count":89,"title":["Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system."],"prefix":"10.1136","volume":"23","author":[{"given":"F J","family":"Branicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D F","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,11,1]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"In: Amlaner CJ Jnr, MacDonald DW.eds. Improved techniques in the construction of pH sensitive radio-pills. A handbook on biotelemetry and radio tracking","author":"Colson, R.H.; Watson, B.W.","year":"1979","unstructured":"Colson RH, Watson BW. In: Amlaner CJ Jnr, MacDonald DW.eds. Improved techniques in the construction of pH sensitive radio-pills. A handbook on biotelemetry and radio tracking. Oxford, New York: Pergamon Press, 1979: 209-12."},{"key":"ref_2","first-page":"414","article-title":"Proceedings of the IIIrd international ambulatory monitoring symposium. Stott","author":"Evans, D.F.; Foster, G.E.; Hardcastle, J.D.; Slater, E.","unstructured":"Evans DF, Foster GE, Hardcastle JD, Slater E. Proceedings of the IIIrd international ambulatory monitoring symposium. Stott F, ed. London and New York: Academic Press, 414-21."},{"key":"ref_3","first-page":"67","article-title":"A miniature 4-channel cassette recorder for physiological and other variables. Biotelemetry IInd International Symposium, Davos 1974","author":"McKinnon, J.","year":"1974","unstructured":"McKinnon J. A miniature 4-channel cassette recorder for physiological and other variables. Biotelemetry IInd International Symposium, Davos 1974. Basel: Karger, 1974: 67-70."},{"key":"ref_4","first-page":"1","article-title":"Physiology of the gastro-oesophageal junction and hiatus hernia","volume-title":"Recent advances in gastroenterology. Edinburgh: Churchill-Livingstone","volume":"3","author":"Lipschutz, W.H.","year":"1976","unstructured":"Lipschutz WH. Physiology of the gastro-oesophageal junction and hiatus hernia. In: Bouchier IAD, ed. Recent advances in gastroenterology. Edinburgh: Churchill-Livingstone, 1976: vol 3: 1-26."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF01072195","article-title":"Oesophageal intraluminal pH recording in the assessment of gastro-oesophageal reflux and its consequences","volume":"22","author":"Atkinson, M.; Van Gelder, A.","year":"1977","unstructured":"Atkinson M, Van Gelder A. Oesophageal intraluminal pH recording in the assessment of gastro-oesophageal reflux and its consequences. Am J Dig Dis 1977; 22: 365-70.","journal-title":"Am J Dig Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000658-197610000-00009","article-title":"Patterns of gastro-oesophageal reflux in health and disease","volume":"184","author":"Demeester, T.R.; Johnson, L.F.; Joseph, G.J.; Toschano, M.S.; Hall, A.W.; Skinner, D.B.","year":"1976","unstructured":"Demeester TR, Johnson LF, Joseph GJ, Toschano MS, Hall AW, Skinner DB. Patterns of gastro-oesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.","journal-title":"Ann Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0025-7125(16)31818-1","article-title":"Gastroesophageal reflux","volume":"62","author":"Fisher, R.S.; Cohen, S.","year":"1978","unstructured":"Fisher RS, Cohen S. Gastroesophageal reflux. Med Clin North Am 1978; 62: 3-20.","journal-title":"Med Clin North Am"},{"key":"ref_8","first-page":"481","article-title":"Gastrooesophageal reflux and oesophageal peristalsis method for 12 hour simultaneous recording of pH and peristaltic activity in the oesophagus","volume":"14","year":"1979","unstructured":"Wallin L, Madsen T, Boesby S, Sorensen 0. Gastrooesophageal reflux and oesophageal peristalsis method for 12 hour simultaneous recording of pH and peristaltic activity in the oesophagus. Scand J Gastroenterol 1979; 14: 481-7.","journal-title":"Scand J Gastroenterol"},{"key":"ref_9","first-page":"66","article-title":"Tubeless tests. Clinical tests of gastric secretion, histology, methodology, interpretation","author":"Baron, J.H.","year":"1978","unstructured":"Baron JH. Tubeless tests. Clinical tests of gastric secretion, histology, methodology, interpretation. London: Macmillan, 1978: 66-7."},{"key":"ref_10","first-page":"213","article-title":"An accurate longterm pH sensitive radio pill for ingestion and implantation","volume":"8","author":"Colson, R.H.; Watson, B.W.; Fairclough, P.D.","year":"1981","unstructured":"Colson RH, Watson BW, Fairclough PD et al. An accurate longterm pH sensitive radio pill for ingestion and implantation. Biotel Patient Monitor 1981; 8: 213-27.","journal-title":"Biotel Patient Monitor"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01073193","article-title":"Controlled trial of a new dosage form of carbenoxolone (pyrogastrone) in the treatment of reflux oesophagitis","volume":"23","author":"Reed, P.I.; Davies, W.A.","year":"1978","unstructured":"Reed PI, Davies WA. Controlled trial of a new dosage form of carbenoxolone (pyrogastrone) in the treatment of reflux oesophagitis. Am J Dig Dis 1978; 23: 161-5.","journal-title":"Am J Dig Dis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0140-6736(66)90472-7","article-title":"Oesophageal acid perfusion in the diagnosis of precordial pain","volume":"2","author":"Bennett, JR, Atkinson; M.","year":"1966","unstructured":"Bennett JR, Atkinson M. Oesophageal acid perfusion in the diagnosis of precordial pain. Lancet 1966; 2: 1150-2.","journal-title":"Lancet"},{"key":"ref_13","first-page":"126","article-title":"Gastro-oesophageal reflux and hiatal hernia. A re-evaluation of current data and dogma","volume":"58","author":"Moosa, A.R.; Skinner, D.B.","year":"1976","unstructured":"Moosa AR, Skinner DB. Gastro-oesophageal reflux and hiatal hernia. A re-evaluation of current data and dogma. Ann R Coll Surg Engl 1976; 58: 126-32.","journal-title":"Ann R Coll Surg Engl"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/gut.18.7.536","article-title":"Correlation between manometric and pH tests for gastrooesophageal reflux","volume":"18","author":"Stanciu, C.; Hoare, R.C.; Bennett, JR","year":"1976","unstructured":"Stanciu C, Hoare RC, Bennett JR. Correlation between manometric and pH tests for gastrooesophageal reflux. Gut 1976; 18: 536-40.","journal-title":"Gut"},{"key":"ref_15","first-page":"1163","article-title":"Outpatient 24-hour oesophageal pH monitoring by telemetry","volume":"78","author":"Falor, W.H.; Hansel, JR, Chang; B, Kraus; FC, White; H.A.","year":"1980","unstructured":"Falor WH, Hansel JR, Chang B, Kraus FC, White HA. Outpatient 24-hour oesophageal pH monitoring by telemetry. Gastroenterology 1980; 78: 1163.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1080\/00365521.1975.12097039","article-title":"Gastro-oesophageal acid reflux and sphincter pressure in normal human subjects","volume":"10","author":"Boesby, S.","year":"1975","unstructured":"Boesby S. Gastro-oesophageal acid reflux and sphincter pressure in normal human subjects. Scand J Gastroenterol 1975; 10: 731-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-5223(19)37879-1","article-title":"Techniques, indications and clinical use of 24-hour oesophageal pH monitoring","volume":"79","author":"Demeester, T.R.; Wang Ching, I.; Wernly, J.A.","year":"1980","unstructured":"Demeester TR, Wang Ching I, Wernly JA et al. Techniques, indications and clinical use of 24-hour oesophageal pH monitoring. J Thorac Cardiovasc Surg 1980; 79: 656-70.","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.23.11.992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T21:23:42Z","timestamp":1757280222000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.23.11.992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,11]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1982,11,1]]},"published-print":{"date-parts":[[1982,11]]}},"alternative-id":["10.1136\/gut.23.11.992"],"URL":"https:\/\/doi.org\/10.1136\/gut.23.11.992","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,11]]}}}