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D-cell density was significantly increased in gastrinoma patients, unchanged in duodenal ulcer, and diminished in pernicious anaemia and after vagotomy. The G\/D-cell ratio was increased in pernicious anaemia and after vagotomy, unchanged in duodenal ulcer, and decreased in gastrinoma patients. It is concluded that the antral pH governs the ratio of G- and D-cells. Therefore, the G\/D cell ratio increases in states of reduced acid secretion and decreases in massive hyperchlorhydria. Hypergastrinaemia as such does not affect the G\/D-cell ratio.<\/jats:p>","DOI":"10.1136\/gut.23.4.285","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"285-291","source":"Crossref","is-referenced-by-count":99,"title":["Antral gastrin-producing G-cells and somatostatin-producing D-cells in different states of gastric acid secretion."],"prefix":"10.1136","volume":"23","author":[{"given":"R","family":"Arnold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M V","family":"H\u00fclst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Neuhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schwarting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H D","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Creutzfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,4,1]]},"reference":[{"key":"ref_1","first-page":"1106","article-title":"Inhibition of gastrin and gastric acid secretion by growth-hormone release-inhibiting hormone","volume":"2","author":"Bloom, SR, Mortimer; CH, Thorner; M.O.","year":"1974","unstructured":"Bloom SR, Mortimer CH, Thorner MO et al. 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