{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:23:51Z","timestamp":1765005831098,"version":"3.46.0"},"reference-count":20,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:p>Sera from 71 patients with acute liver injury have been tested for antibodies to hepatocyte membrane lipoprotein complex (LSP) using a sensitive radioimmunoassay. Two main patterns of anti-LSP response were seen. In the first, seen in patients with type A and B viral hepatitis, anti-LSP antibodies were detectable at presentation, with the highest titres two to 10 days before the peak in serum aminotransferases and, in the hepatitis B patients, when viral DNA polymerase concentrations were still high, indicating active viral replication. These findings are consistent with the anti-LSP response being consequent on an interaction between T cells and neoantigens on the liver cell surface. A similar pattern was found in halothane hepatitis where immune responses to a halothane-altered liver membrane antigen are present early in the course of the disease. In the second type of response, exemplified by cases with paracetamol-induced hepatic necrosis, anti-LSP was only occasionally detectable at presentation, although present in very low titre later in the clinical course. This may be due to the release of altered antigen at the time of hepatocellular injury. The same pattern was found in a selected group of patients with uncomplicated acute alcoholic hepatitis, suggesting that in both these groups of patients the liver damage may have been due to a direct toxic effect on liver cells.<\/jats:p>","DOI":"10.1136\/gut.23.7.603","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"603-607","source":"Crossref","is-referenced-by-count":11,"title":["Anti-LSP antibodies in acute liver disease."],"prefix":"10.1136","volume":"23","author":[{"given":"R","family":"Meliconi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Perperas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I G","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Eddleston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197807062990101","article-title":"Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis","volume":"299","author":"Jensen, D.M.; McFarlane, I.G.; Portman, B.S.; Eddleston, A.L.W.F.; Williams, R.","year":"1978","unstructured":"Jensen DM, McFarlane IG, Portman BS, Eddleston ALWF, Williams R. Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med 1978; 299: 1-7.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(74)90287-6","article-title":"Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis","volume":"2","author":"Eddleston, A.L.W.F.; Williams, R.","year":"1974","unstructured":"Eddleston ALWF, Williams R. Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis. Lancet 1974; 2: 1543-5.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2177\/jsci.1.P1","article-title":"The development of a radioimmunoassay for the detection of antibodies to a liver-specific membrane lipoprotein (LSP)","volume":"1","author":"Jensen, D.M.; McFarlane, I.G.; Nicholson, A.; Eddleston, A.L.W.F.; Williams, R.","year":"1978","unstructured":"Jensen DM, McFarlane IG, Nicholson A, Eddleston ALWF, Williams R. The development of a radioimmunoassay for the detection of antibodies to a liver-specific membrane lipoprotein (LSP). J Clin Lab Immunol 1978; 1: 1-7.","journal-title":"J Clin Lab Immunol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1128\/JVI.12.5.995-1005.1973","article-title":"DNA polymerase associated with human hepatitis B","volume":"12","author":"Kaplan, P.M.; Greenman, R.L.; Gerin, J.L.; Purcell, R.H.; Robinson, W.S.","year":"1973","unstructured":"Kaplan PM, Greenman RL, Gerin JL, Purcell RH, Robinson WS. DNA polymerase associated with human hepatitis B. J Virol 1973; 12: 995-1005.","journal-title":"J Virol"},{"key":"ref_5","first-page":"396","article-title":"Liver cell surface localisation of hepatitis B antigen and of immunoglobulins in acute and chronic hepatitis and in liver cirrhosis. Clin Exp Immunol","volume":"25","author":"Alberti, A.; Realdi, G.; Tremolada, F.; Spina, G.P.","year":"1976","unstructured":"Alberti A, Realdi G, Tremolada F, Spina GP. 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Clin Exp Immunol 1979; 37: 205-12."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.23.7.603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:20:37Z","timestamp":1765005637000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.23.7.603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1982,7,1]]},"published-print":{"date-parts":[[1982,7]]}},"alternative-id":["10.1136\/gut.23.7.603"],"URL":"https:\/\/doi.org\/10.1136\/gut.23.7.603","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}