{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:29:28Z","timestamp":1772083768606,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>The lactulose H2 breath test is in use as a simple non-invasive measurement of mouth to caecum transit time, but its reproducibility has never been assessed. We have examined the reproducibility of mouth to caecum transit time in 21 normal subjects using lactulose 10, 15, and 20 g; seven subjects being studied with 10 g and 12 each with 15 and 20 g doses. Transit time decreased with increasing doses of lactulose although the differences were not significant between or within (n = 5) individuals. Variation in transit times between individuals was considerable with all doses of lactulose (mean coefficient of variation of 18.5, 29.7 and 28.3% with 10, 15, and 20 g respectively). The addition of lactulose to a liquid meal containing carbohydrate, fat, and protein decreased the coefficient of variation to less than 10% in four subjects studied. The lactulose H2 breath test could be made more reproducible by including a liquid meal.<\/jats:p>","DOI":"10.1136\/gut.24.10.893","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"893-896","source":"Crossref","is-referenced-by-count":122,"title":["Assessment of the reproducibility of the lactulose H2 breath test as a measure of mouth to caecum transit time."],"prefix":"10.1136","volume":"24","author":[{"given":"S J","family":"La Brooy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Male","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Beavis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Misiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJM196907172810303","article-title":"Production and excretion of hydrogen gas in man","volume":"281","author":"Levitt, MD","year":"1969","unstructured":"Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med 1969; 281: 122-7.","journal-title":"N Engl J Med"},{"key":"ref_2","first-page":"546","article-title":"Investigation of small bowel transit time in man utilising pulmonary hydrogen (H,) measurement","volume":"85","year":"1975","unstructured":"Bond JH, Levitt MD. Investigation of small bowel transit time in man utilising pulmonary hydrogen (H,) measurement. J Lab Clin Med 1975; 85: 546-55.","journal-title":"J Lab Clin Med"},{"key":"ref_3","first-page":"237","article-title":"A simple method of measuring breath hydrogen reproducible. The most likely reason for this is the in carbohydrate malabsorption by end-expiratory interdigestive activity front that occurs in the small sampling","volume":"50","author":"Metz, G.; Gassull, M.A.; Leeds, A.R.; Blendis, L.M.; Jenkins, D.J.A.","year":"1976","unstructured":"Metz G, Gassull MA, Leeds AR, Blendis LM, Jenkins DJA. A simple method of measuring breath hydrogen reproducible. The most likely reason for this is the in carbohydrate malabsorption by end-expiratory interdigestive activity front that occurs in the small sampling. Clin Sci Mol Med 1976; 50: 237-40.","journal-title":"Clin Sci Mol Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.1968.tb19034.x","article-title":"The use of expired air to measure intestinal gas formation","volume":"150","author":"Calloway, D.H.; Murphy, E.L.","year":"1968","unstructured":"Calloway DH, Murphy EL. The use of expired air to measure intestinal gas formation. Ann NY Acad Sci 1968; 150: 82-95.","journal-title":"Ann NY Acad Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1113\/jphysiol.1975.sp010891","article-title":"The interdigestive myoelectric complex of the stomach and small bowel of dogs","volume":"246","author":"Code, C.F.; Marlett, J.A.","year":"1975","unstructured":"Code CF, Marlett JA. The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (Lond) 1975; 246: 289-309.","journal-title":"J Physiol (Lond)"},{"key":"ref_6","first-page":"261","article-title":"Variation in the glucose tolerance test with normal changes in fasting upper gastrointestinal motility","volume":"57","author":"Thompson, D.G.; Archer, L.; Benson, M.; Green, W.; Hardy, R.; Wingate, D.L.","year":"1979","unstructured":"Thompson DG, Archer L, Benson M, Green W, Hardy R, Wingate DL. Variation in the glucose tolerance test with normal changes in fasting upper gastrointestinal motility. Clin Sci 1979; 57: 261.","journal-title":"Clin Sci"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1136\/bmj.1.6124.1392","article-title":"Dietary fibre, fibre analogues and glucose tolerance: importance of viscocity","volume":"1","author":"Jenkins, D.J.A.; Wolever, T.M.S.; Leeds, A.R.","year":"1978","unstructured":"Jenkins DJA, Wolever TMS, Leeds AR et al. Dietary fibre, fibre analogues and glucose tolerance: importance of viscocity. Br Med J 1978; 1: 1392-4.","journal-title":"Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/BF01694513","article-title":"Effect of synthetic motilin on gastric motor activity in conscious dogs","volume":"22","author":"Itoh, Z.; Takeuchi, S.; Aizawa, I.; Takayanagi, R.","year":"1977","unstructured":"Itoh Z, Takeuchi S, Aizawa I, Takayanagi R. Effect of synthetic motilin on gastric motor activity in conscious dogs. Dig Dis 1977; 22: 813-9.","journal-title":"Dig Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/BF01079786","article-title":"Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog","volume":"23","author":"Ormsbee, H.S.; Hoehler, S.L.; Tefford, G.L.","year":"1978","unstructured":"Ormsbee HS, Hoehler SL, Tefford GL. Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog. Dig Dis 1978; 23: 781-8.","journal-title":"Dig Dis"},{"key":"ref_10","first-page":"753","article-title":"Intestinal propulsion in the dog. Its relation to food intake and intermediate group, who are occasional nonthe migratory myoelectric complex. Gastroenterology producers of H2. This could be because they","volume":"70","author":"Summers, R.W.; Helm, J.; Christensen, J.","year":"1976","unstructured":"Summers RW, Helm J, Christensen J. Intestinal propulsion in the dog. Its relation to food intake and intermediate group, who are occasional nonthe migratory myoelectric complex. Gastroenterology producers of H2. This could be because they 1976; 70: 753-8."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.10.893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:30:47Z","timestamp":1765614647000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.10.893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1983,10,1]]},"published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1136\/gut.24.10.893"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.10.893","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}