{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:54:12Z","timestamp":1775602452670,"version":"3.50.1"},"reference-count":27,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,12]]},"abstract":"<jats:p>We have studied 80 patients with pernicious anaemia. Upper gastrointestinal endoscopy (with biopsy and cytology) showed no lesion other than atrophic gastritis in 34 patients. Thirty three patients, however, had varying degrees of gastric mucosal dysplasia, which was detected more frequently by histology than by cytology. The endoscopic appearance of the mucosa was abnormal in four of the six patients with moderate dysplasia, and in all three patients with severe dysplasia. One patient was found to have a small carcinoma in the gastric antrum, and underwent total gastrectomy; 18 patients had polyps (often multiple); four of these were treated by endoscopic polypectomy. One of the patients with polyps had multiple carcinoid tumours, and an asymptomatic parathyroid adenoma. Seventeen of the patients also underwent barium meal examination; abnormalities were revealed in only three of the seven patients with lesions visible at endoscopy. Our results justify further endoscopic studies in patients with pernicious anaemia, and sequential examinations to establish the natural history of gastric dysplasia.<\/jats:p>","DOI":"10.1136\/gut.24.12.1141","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1141-1147","source":"Crossref","is-referenced-by-count":100,"title":["Gastroscopic screening in 80 patients with pernicious anaemia."],"prefix":"10.1136","volume":"24","author":[{"given":"R W","family":"Stockbr\u00fcgger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G G","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J O","family":"Beilby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R R","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,12,1]]},"reference":[{"key":"ref_1","first-page":"339","article-title":"Pernicious anaemia and carcinoma of the stomach - autopsy study concerning their interrelationship","volume":"209","author":"Kaplan, H.S.; Rigler, L.G.","unstructured":"Kaplan HS, Rigler LG. 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German Haematological Society, International Congress at Munster, Lancet 1937; 1: 1404."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF01071995","article-title":"A reappraisal of the nature and significance of chronic atrophic gastritis","volume":"18","author":"Strickland, R.G.; Mackay, I.R.","year":"1973","unstructured":"Strickland RG, Mackay IR. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis 1973; 18: 426-40.","journal-title":"Am J Dig Dis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/00365521.1977.12031136","article-title":"Antral gastrin cells and serum gastrin in achlorhydria","volume":"12","author":"Stockbrugger, R.W.; Larsson, L.I.; Lundqvist, G.; Angervall, L.","year":"1977","unstructured":"Stockbrugger RW, Larsson LI, Lundqvist G, Angervall L. Antral gastrin cells and serum gastrin in achlorhydria. 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Lancet 1978; 2: 521-3.","journal-title":"Lancet"},{"key":"ref_18","first-page":"550","article-title":"Gastric juice N-nitrosamines in health and gastroduodenal disease","volume":"2","author":"Reed, P.I.; Smith, P.L.R.; Haines, K.; House, F.R.; Walters, C.L.","year":"1981","unstructured":"Reed PI, Smith PLR, Haines K, House FR, Walters CL. Gastric juice N-nitrosamines in health and gastroduodenal disease. Lancet 1981; 2: 550-2.","journal-title":"Lancet"},{"key":"ref_19","first-page":"108","article-title":"Gastric nitrate, nitrite and bacterial nitrate-reductase in relation to gastric acid secretion","author":"Bartholomew, B.; Stockbrugger, R.W.; Eugenides, N.; Mansell, P.; Hill, M.J.; Cotton, P.B.","year":"1980","unstructured":"Bartholomew B, Stockbrugger RW, Eugenides N, Mansell P, Hill MJ, Cotton PB. Gastric nitrate, nitrite and bacterial nitrate-reductase in relation to gastric acid secretion. [Abstract] XI Congr Gastroenterology, Hamburg 1980 Hepato-Gastroenterol 1980, suppl. p. 108.","journal-title":"[Abstract] XI Congr Gastroenterology, Hamburg"},{"key":"ref_20","first-page":"53","article-title":"Mixed endocrine gastric tumours associated with hypergastrineaemia of antral origin","volume":"93","author":"Larsson, L.I.; Rehfeld, J.F.; Stockbrugger, R.W.","year":"1978","unstructured":"Larsson LI, Rehfeld JF, Stockbrugger RW et al. Mixed endocrine gastric tumours associated with hypergastrineaemia of antral origin. Am J Pathol 1978; 93: 53-68.","journal-title":"Am J Pathol"},{"key":"ref_21","first-page":"95","article-title":"cases of multiple gastric carcinoids","volume":"9","author":"P, Garin Chesa; JM, Polak","year":"1979","unstructured":"Garin Chesa P, Polak JM, Timson CM et al. Histochemical and ultrastructural studies of 9 cases of multiple gastric carcinoids. Pathol Res Pract 1979; 165: 95.","journal-title":"Timson CM et al. 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Cancer 1981; 47: 2620-6.","journal-title":"Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0300-5089(21)00792-6","article-title":"Screening for gastric cancer in Japan","volume":"7","author":"Kawai, K.","year":"1978","unstructured":"Kawai K. Screening for gastric cancer in Japan. Clin Gastroenterol 1978; 7: 605-22.","journal-title":"Clin Gastroenterol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0016-5085(19)32124-9","article-title":"Carcinoma and possible precancerous changes of the gastric stump after BII-resection","volume":"73","author":"Domellof, L.; Eriksson, S.; Janunger, K.G.","year":"1977","unstructured":"Domellof L, Eriksson S, Janunger KG. Carcinoma and possible precancerous changes of the gastric stump after BII-resection. 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Cancer in colitis: assessment of the individual risk by clinical and histological criteria. Gastroenterology 1977; 73: 1280-9.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.12.1141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:50:49Z","timestamp":1765641049000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.12.1141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,12]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1983,12,1]]},"published-print":{"date-parts":[[1983,12]]}},"alternative-id":["10.1136\/gut.24.12.1141"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.12.1141","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,12]]}}}