{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:05:17Z","timestamp":1772816717065,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,12]]},"abstract":"<jats:p>Fifty two patients with Crohn's disease (31 outpatients and 21 inpatients) were investigated for evidence of vitamin A deficiency. Eleven (21%) had low plasma retinol concentrations (less than 1.2 mumol\/l (34.3 micrograms %)). Five of these were outpatients and plasma retinol was only slightly reduced (greater than 1.0 mumol\/l (28.6%)). All outpatients weighed 80% or more of ideal, and were considered at low risk of developing vitamin A deficiency. In contrast, of the six inpatients with low plasma retinol concentration, five had a level of less than 1.0 mumol\/l (28.6 micrograms %) and weighed less than 80% ideal. Three of these had impaired dark adaptation and a plasma retinol concentration of less than 0.8 mumol\/l (less than 22.9 micrograms %). As a group, the inpatients were more protein depleted than the outpatients, with respect to serum albumin (p less than 0.01), transferrin (p less than 0.001), and prealbumin (p less than 0.001) but retinol binding protein levels were not significantly lower. It is suggested that patients with extensive small bowel Crohn's disease, who weigh less than 80% of ideal weight, merit measurement of plasma retinol concentration. Those with plasma retinol less than 0.8 mumol\/l (less than 22.9 micrograms %) run a high risk of night blindness. Vitamin supplements should be given and protein depletion corrected.<\/jats:p>","DOI":"10.1136\/gut.24.12.1169","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1169-1175","source":"Crossref","is-referenced-by-count":32,"title":["Vitamin A deficiency in Crohn's disease."],"prefix":"10.1136","volume":"24","author":[{"given":"A N","family":"Main","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R I","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bronte-Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"McLelland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Shenkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,12,1]]},"reference":[{"key":"ref_1","first-page":"1161","article-title":"Dark adaptation testing for diagnosis of subclinical vitamin A deficiency and evaluation of therapy","volume":"2","author":"Russell, R.M.; Smith, V.C.; Multack, R.; Krill, A.E.; Rosenberg, I.H.","year":"1973","unstructured":"Russell RM, Smith VC, Multack R, Krill AE, Rosenberg IH. Dark adaptation testing for diagnosis of subclinical vitamin A deficiency and evaluation of therapy. Lancet 1973; 2: 1161-4.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.7326\/0003-4819-88-5-622","article-title":"Vitamin A reversal of abnormal dark adaptation in cirrhosis - study of effects on the plasma retinol transport system","volume":"88","author":"Russell, R.M.; Morrison, S.A.; Smith, F.R.; Oaks, E.V.; Carney, E.A.","year":"1978","unstructured":"Russell RM, Morrison SA, Smith FR, Oaks EV, Carney EA. Vitamin A reversal of abnormal dark adaptation in cirrhosis - study of effects on the plasma retinol transport system. 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Correlation of dark adaptation test results with serum vitamin A levels in diseased adults. J Nutr 1980; 110: 552-7.","journal-title":"J Nutr"},{"key":"ref_5","article-title":"The assessment of the nutritional status of the community. Monograph No 53","author":"Jelliffe, D.B.","year":"1966","unstructured":"Jelliffe DB. The assessment of the nutritional status of the community. Monograph No 53. Geneva: WHO, 1966."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","article-title":"Immunochemical quantitation of antigens by single radial immunodiffusion","volume":"2","author":"Mancini, G.; Carbonara, A.O.; Heremans, J.F.","year":"1965","unstructured":"Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. 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Clin Chim Acta 1980; 103: 325-34.","journal-title":"Clin Chim Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0021-9258(18)57092-7","article-title":"Rapid method for the determination of fat in faeces","volume":"177","author":"de Kamer JH, Van; HT, Bokkel-Huinink; HA, Weyers","year":"1949","unstructured":"Van de Kamer JH, Bokkel-Huinink HT, Weyers HA. Rapid method for the determination of fat in faeces. J Biol Chem 1949; 177: 347-55.","journal-title":"J Biol Chem"},{"key":"ref_12","article-title":"Vitamin A deficiency and xerophthalmia. Tech Rep WHO Ser No 672","author":"Anonymous","year":"1982","unstructured":"Anonymous. Vitamin A deficiency and xerophthalmia. Tech Rep WHO Ser No 672. Geneva: WHO, 1982."},{"key":"ref_13","first-page":"173","volume-title":"The assessment of vitamin A status. Proc Nutr Soc 1981","volume":"40","author":"Pitt, G.A.J.","unstructured":"Pitt GAJ. The assessment of vitamin A status. Proc Nutr Soc 1981; 40: 173-8."},{"key":"ref_14","first-page":"49","article-title":"Distribution of vitamin","volume-title":"A in human liver. Proc Nutr Soc 1979","volume":"38","author":"McLaren, D.S.; Mawlayi, Z.; Downing, A.","unstructured":"McLaren DS, Mawlayi Z, Downing A. Distribution of vitamin A in human liver. Proc Nutr Soc 1979; 38: 49A."},{"key":"ref_15","first-page":"230","article-title":"Rapid turnover transport proteins: an index of subclinical protein-energy malnutrition","volume":"2","author":"Shetty, P.S.; Watrasiewicz, K.E.; Jung, R.T.; James, W.P.T.","year":"1979","unstructured":"Shetty PS, Watrasiewicz KE, Jung RT, James WPT. Rapid turnover transport proteins: an index of subclinical protein-energy malnutrition. 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Vitam Horm (NY) 1974; 32: 167-80.","journal-title":"Vitam Horm (NY)"},{"key":"ref_18","first-page":"313","article-title":"Retinol-binding protein, prealbumin and vitamin A transport","volume-title":"components of plasma: isolation and clinical significance","author":"Goodman, D.S.","year":"1976","unstructured":"Goodman DS. Retinol-binding protein, prealbumin and vitamin A transport. In: Jamieson GS, Greenwalt TJ, eds. Trace components of plasma: isolation and clinical significance. New York: Liss, 1976: 313-30."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ajcn\/26.9.973","article-title":"Serum vitamin A retinol-binding protein and prealbumin concentrations in protein-calorie malnutrition. 1. A functional defect in hepatic retinol release","volume":"26","author":"Smith, F.R.; Goodman, D.S.; Zaklama, M.S.; Gabr, M.K.; ElMaraghy, S.; Patwardhan, V.N.","year":"1973","unstructured":"Smith FR, Goodman DS, Zaklama MS, Gabr MK, ElMaraghy S, Patwardhan VN. Serum vitamin A retinol-binding protein and prealbumin concentrations in protein-calorie malnutrition. 1. A functional defect in hepatic retinol release. Am J Clin Nutr 1973; 26: 973-81.","journal-title":"Am J Clin Nutr"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0021-9258(19)45460-4","article-title":"Regulation of retinol-binding protein metabolism by vitamin A status in the rat","volume":"247","author":"Mato, Y.; Smith, J.E.; Goodman, D.S.","year":"1972","unstructured":"Mato Y, Smith JE, Goodman DS. Regulation of retinol-binding protein metabolism by vitamin A status in the rat. J Biol Chem 1972; 247: 2542-50.","journal-title":"J Biol Chem"},{"key":"ref_21","first-page":"2504","article-title":"Retinol-binding protein and the regulation of vitamin","volume-title":"A transport. Fed Proc 1979","volume":"38","author":"Smith, J.E.; Goodman, D.S.","unstructured":"Smith JE, Goodman DS. 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