{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:49:22Z","timestamp":1766738962079,"version":"3.48.0"},"reference-count":28,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:p>Changes in serum immunoreactive prolyl hydroxylase protein (IRPH), galactosylhydroxylysyl glucosyltransferase activity (GGT) and the aminoterminal propeptide of type III procollagen [Pro(III)-N-P] were studied in 21 patients with primary biliary cirrhosis during a follow-up period of up to three years. The patients received either D-penicillamine (600 mg\/day), medroxyprogesterone acetate (5 mg\/day), or a placebo, or no treatment after the D-penicillamine or medroxyprogesterone medication, each period lasting from nine to 15 months. The individual serum IRPH, GGT, and Pro(III)-N-P concentrations exceeded the upper normal limit in most patients. No significant changes were found in any of these three serum markers during any of the five different periods, nor was there any evidence for a decrease in the raised prolyl 4-hydroxylase activity in the hepatic biopsy specimens in response to any of the treatments. Galactosylhydroxylysyl glucosyltransferase activity decreased significantly in these specimens during medroxyprogesterone therapy, but the interpretation of this, the only positive change, remains unclear. The data suggest that D-penicillamine or medroxyprogesterone therapy may have no favourable effect on the increased hepatic collagen formation involved in primary biliary cirrhosis.<\/jats:p>","DOI":"10.1136\/gut.24.2.136","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"136-142","source":"Crossref","is-referenced-by-count":35,"title":["Enzymes of collagen synthesis and type III procollagen aminopropeptide in the evaluation of D-penicillamine and medroxyprogesterone treatments of primary biliary cirrhosis."],"prefix":"10.1136","volume":"24","author":[{"given":"E R","family":"Savolainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T A","family":"Miettinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Pikkarainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Salaspuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K I","family":"Kivirikko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,2,1]]},"reference":[{"key":"ref_1","first-page":"831","article-title":"A controlled trial of D-penicillamine therapy in primary biliary cirrhosis","volume":"1","author":"Jain, S.; Scheuer, P.J.; Sherlock, Samourian S.McGee J.O.'D.; S.","year":"1977","unstructured":"Jain S, Scheuer PJ, Samourian S. McGee JO'D. Sherlock S. A controlled trial of D-penicillamine therapy in primary biliary cirrhosis. Lancet 1977; 1: 831-4.","journal-title":"Lancet"},{"key":"ref_2","first-page":"587","article-title":"Asymptomatic primary biliary cirrhosis. Presentation, histology, and results with D-penicillamine","volume-title":"Mayo Clin Proc","volume":"53","author":"Fleming, C.R.; Ludwig, J.; Dickson, E.R.","year":"1978","unstructured":"Fleming CR, Ludwig J, Dickson ER. Asymptomatic primary biliary cirrhosis. Presentation, histology, and results with D-penicillamine. Mayo Clin Proc 1978; 53: 587-93."},{"key":"ref_3","first-page":"487","article-title":"Primary biliary cirrhosis","volume-title":"Progress in liver diseases, vol VI","author":"Dickson, E.R.; Fleming, C.R.; Ludwig, J.","year":"1979","unstructured":"Dickson ER, Fleming CR, Ludwig J. Primary biliary cirrhosis. In: Popper H, Schaffner F, eds. Progress in liver diseases, vol VI. New York: Grune and Stratton, 1979: 487-502."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1056\/NEJM197902083000602","article-title":"Reducation of immune complexes and immunoglobulins induced by D-penicillamine in primary biliary cirrhosis","volume":"300","year":"1979","unstructured":"Epstein 0, De Villiers D, Jain S, Potter BJ, Thomas HC, Sherlock S. Reducation of immune complexes and immunoglobulins induced by D-penicillamine in primary biliary cirrhosis. N Engl J Med 1979; 300: 274-8.","journal-title":"N Engl J Med"},{"key":"ref_5","first-page":"1275","article-title":"D-penicillamine treatment improves survival in primary biliary cirrhosis","volume":"1","author":"S, Scheuer P.J.Sherlock","year":"1981","unstructured":"Scheuer PJ. Sherlock S. D-penicillamine treatment improves survival in primary biliary cirrhosis. 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Effects of medroxyprogesterone on the liver function and drug metabolism of patients with primary biliary cirrhosis and chronic active hepatitis. J Med 1978; 9: 117-28.","journal-title":"J Med"},{"key":"ref_8","first-page":"53","article-title":"The enzsmologs of post-translaitional modification of proteins","year":"1980","unstructured":"eds. The enzsmologs of post-translaitional modification of proteins. London: Academic Press. 1980): 53-104."},{"issue":"8","key":"ref_9","first-page":"23","article-title":"Collagen glycosyltransferases","volume":"1979","author":"R, Kivirikko K.I.Myllyki","unstructured":"Kivirikko KI. Myllyki R. Collagen glycosyltransferases. 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(In press.)"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.2.136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:44:10Z","timestamp":1765651450000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.2.136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1983,2,1]]},"published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1136\/gut.24.2.136"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.2.136","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}