{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:49:51Z","timestamp":1765658991654,"version":"3.48.0"},"reference-count":6,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:p>In the pylorus ligated rat vagotomy has been attempted by chemoneurolysis with alcohol. Surgical truncal vagotomy reduced the intragastric acid produced in a five-hour period from 310 +\/- 17.6 (SD) mumol to 5.4 +\/- 2.4 mumol with a marked reduction in the ulcer score. Injection of 30% alcohol in the region of the vagal trunks at the level of the lower oesophagus produced a marked reduction in gastric acid secretion (7.6 +\/- 3.7 mumol). Injection of solutions of alcohol in concentrations over 10% along the lesser curvature reduced gastric acid output to less than 10 mumol with a corresponding reduction in the ulcer score. Four months after the injection of 30% alcohol along the lesser curvature the acid output was 23.0 +\/- 5.7 mumol and no gastric ulceration occurred.<\/jats:p>","DOI":"10.1136\/gut.24.2.158","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"158-160","source":"Crossref","is-referenced-by-count":4,"title":["Vagotomy by chemoneurolysis: an experimental study in the rat."],"prefix":"10.1136","volume":"24","author":[{"given":"T V","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P L","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Heading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,2,1]]},"reference":[{"issue":"1","key":"ref_1","first-page":"1026","article-title":"Chemical sympathectomy","volume":"1969","author":"HA, I.Haxton","unstructured":"I Haxton HA. Chemical sympathectomy. Br MedJ 1969; 1: 1026-8.","journal-title":"Br MedJ"},{"key":"ref_2","first-page":"167","article-title":"A new approach to the so-called physiology of cardiospasm; experimental production of cardiospasm in cats after destruction of Auerbach's plexus","volume":"146","author":"Deloyers, L.; Cordier, R.; Duprez, M.A.","year":"1957","unstructured":"Deloyers L, Cordier R, Duprez MA. A new approach to the so-called physiology of cardiospasm; experimental production of cardiospasm in cats after destruction of Auerbach's plexus. Ann Surg 1957; 146: 167-71.","journal-title":"Ann Surg"},{"key":"ref_3","first-page":"84","article-title":"Injection of 5% phenol into submucosa of denervated gastric pouch","volume":"94","author":"Schapiro, H.; Britt, L.G.","year":"1967","unstructured":"Schapiro H, Britt LG. Injection of 5% phenol into submucosa of denervated gastric pouch. Arch Surg 1967; 94: 84 1-5.","journal-title":"Arch Surg"},{"key":"ref_4","first-page":"534","article-title":"Submucosal vagotomy of the canine gastric fundus","volume":"144","author":"Schapiro, H.; McDougal, H.D.; Rosato, Carwell G.; FE, Jackson; N.H.","year":"1977","unstructured":"Schapiro H, McDougal HD, Carwell G. Rosato FE, Jackson NH. Submucosal vagotomy of the canine gastric fundus. Surg Gynec Obstet 1977; 144: 534-6.","journal-title":"Surg Gynec Obstet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/archsurg.1949.01240040215004","article-title":"Effects of vagotomy in the rat","volume":"59","author":"SA, Shay H.Komarov; M, Gruenstein","year":"1949","unstructured":"Shay H. Komarov SA, Gruenstein M. Effects of vagotomy in the rat. Arch Surg 1949; 59: 210-26.","journal-title":"Arch Surg"},{"key":"ref_6","first-page":"139","article-title":"Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat","volume":"305","author":"llakanson R; J, Hedenbro; G, Leidberg; F, Sundler; S, Vallgren","year":"1980","unstructured":"llakanson R, Hedenbro J, Leidberg G, Sundler F, Vallgren S. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. J Phvsiol 1980; 305: 139-45.","journal-title":"J Phvsiol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.2.158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:48:05Z","timestamp":1765658885000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.2.158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1983,2,1]]},"published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1136\/gut.24.2.158"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.2.158","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}