{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:43:51Z","timestamp":1771865031855,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:p>A non-invasive method of imaging and assessing inflammatory bowel disease is described. 111Indium labelled leucocyte scans were performed on 33 patients with a wide variety of inflammatory bowel diseases and 25 control patients. All patients with moderate or severe inflammatory bowel disease had positive scans with localisation of abnormal activity corresponding to the sites assessed to be diseased by radiology in either small or large bowel. No false positives were recorded in the control patients. Faecal excretion of 111In labelled leucocytes was increased in patients with inflammatory bowel disease according to disease severity and correlated with disease activity assessed by serum C-reactive protein levels (r = 0.74, p less than 0.001) or in those patients with Crohn's disease by Crohn's Disease Activity Index (r = 0.78, p less than 0.001). These data suggest that 111In labelled leucocytes may be used to provide a safe, non-invasive method of imaging diseased bowel and objectively assessing disease activity.<\/jats:p>","DOI":"10.1136\/gut.24.4.293","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"293-299","source":"Crossref","is-referenced-by-count":73,"title":["111Indium autologous leucocytes in inflammatory bowel disease."],"prefix":"10.1136","volume":"24","author":[{"given":"S H","family":"Saverymuttu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Lavender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V S","family":"Chadwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,4,1]]},"reference":[{"key":"ref_1","first-page":"1014","article-title":"Indium-111-labelled autologous leucocytes in man","volume":"18","author":"Thakur, M.L.; Lavender, J.P.; Arnot, R.N.; Silvester, D.J.; Segal, A.W.","year":"1977","unstructured":"Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium-111-labelled autologous leucocytes in man. J Nucl Med 1977; 18: 1014-21.","journal-title":"J Nucl Med"},{"key":"ref_2","article-title":"Indium-111-labelled leucocytes for localisation of abscesses. Lancet 1976; 2: 1056-8. 'Indium autologous leucocytes in inflammatory bowel disease","author":"Segal, A.W.; Thakur, M.L.; Arnot, R.L.; Lavender, J.P.","unstructured":"Segal AW, Thakur ML, Arnot RL, Lavender JP. Indium-111-labelled leucocytes for localisation of abscesses. Lancet 1976; 2: 1056-8. 'Indium autologous leucocytes in inflammatory bowel disease"},{"key":"ref_3","first-page":"114","article-title":"Indium-111-autologous tagged leucocytes in the diagnosis of intra-peritoneal sepsis","volume":"1979","author":"Ascher, N.L.; Ahrewholz, D.H.; Simmons, R.L.","unstructured":"Ascher NL, Ahrewholz DH, Simmons RL et al. Indium-111-autologous tagged leucocytes in the diagnosis of intra-peritoneal sepsis. Arch Surg 1979: 114: 386-92.","journal-title":"Arch Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0002-9610(80)90237-8","article-title":"Indium-l1l-labelled leucocytes in the evaluation of suspected abdominal abscesses","volume":"139","author":"Coleman, R.E.; Welch, Black R.E.; DM, Maxwell; J.G.","year":"1980","unstructured":"Coleman RE, Black RE. Welch DM, Maxwell JG. Indium-l1l-labelled leucocytes in the evaluation of suspected abdominal abscesses. Am J Surg 1980; 139: 99-104.","journal-title":"Am J Surg"},{"key":"ref_5","first-page":"672","article-title":"Clinical use of Indium 111 oxime labelled leucocytes in the detection of inflammation or abscesses","volume":"19","author":"L, Forstrom L.Gomez; B, Weiblen; J, Hoogland D.McCulloch; M, Loken","year":"1978","unstructured":"Forstrom L. Gomez L, Weiblen B, Hoogland D. McCulloch J, Loken M. Clinical use of Indium 111 oxime labelled leucocytes in the detection of inflammation or abscesses. 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J Nucl Med 1980; 21: 89.","journal-title":"J Nucl Med"},{"key":"ref_8","first-page":"418","article-title":"\"'Indium labelled autologous Ieucocytes in Crohn's disease","volume":"22","author":"Saverymuttu, S.H.; Peters, A.M.; Lavender, J.P.; Hodgson, H.J.; Chadwick, V.S.","year":"1981","unstructured":"Saverymuttu SH, Peters AM, Lavender JP, Hodgson HJ, Chadwick VS. \"'Indium labelled autologous Ieucocytes in Crohn's disease. Gut 1981; 22: A418.","journal-title":"Gut"},{"key":"ref_9","first-page":"707","article-title":"Imaging diseased bowel with Indium\"' labelled leucocytes","volume":"54","author":"Saverymuttu, S.H.; Peters, A.M.; Lavender, J.P.; Hodgson, H.J.; Chadwick, V.S.","year":"1981","unstructured":"Saverymuttu SH, Peters AM, Lavender JP, Hodgson HJ, Chadwick VS. Imaging diseased bowel with Indium\"' labelled leucocytes. Br J Radiol 1981; 54: 707.","journal-title":"Br J Radiol"},{"key":"ref_10","first-page":"230","article-title":"Indium\"' tagged leucocytes in the diagnosis of inflammatory bowel disease","volume":"2","author":"Segal, A.W.; Ensell, J.; Munro, J.A.; Sarner, M.","year":"1981","unstructured":"Segal AW, Ensell J, Munro JA, Sarner M. Indium\"' tagged leucocytes in the diagnosis of inflammatory bowel disease. Lancet 1981; 2: 230-2.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of the Crohn's Disease Activity Index","volume":"70","author":"Best, W.R.; Singleton, Becktel J.M.; JW, Kern; F.","year":"1976","unstructured":"Best WR, Becktel JM. Singleton JW, Kern F. Development of the Crohn's Disease Activity Index. Gastroenterology 1976; 70: 439-44.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"283","article-title":"Immunological studies in inflammatory bowel disease. In: Immunology of the gut","volume":"46","author":"Pepys, M.B.; Druguet, M.; Klass, H.J.; Dash, A.C.; Mirjah, D.D.; Petrie, A.","year":"1977","unstructured":"Pepys MB, Druguet M, Klass HJ, Dash AC, Mirjah DD, Petrie A. Immunological studies in inflammatory bowel disease. In: Immunology of the gut. Ciba Foundation Symposium No. 46. Amsterdam: Elsevier\/ N. Holland\/Excerpta Medica, 1977: 283-304.","journal-title":"Ciba Foundation Symposium"},{"key":"ref_13","first-page":"448","article-title":"Gallium-67 scanning at 6hr in active inflammatory bowel disease. Case report","volume":"18","author":"Kaplan, L.R.; Griep, R.J.; Schuffler, M.D.; Silliman, R.A.","year":"1977","unstructured":"Kaplan LR, Griep RJ, Schuffler MD, Silliman RA. Gallium-67 scanning at 6hr in active inflammatory bowel disease. Case report. 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J Nucl Med 1977; 18: 1020-4.","journal-title":"J Nucl Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.4.293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:17:32Z","timestamp":1765009052000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.4.293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1983,4,1]]},"published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1136\/gut.24.4.293"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.4.293","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}