{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:28:04Z","timestamp":1790310484365,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:p>HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18 . 6, and 15 . 0, respectively. Children with coeliac disease were significantly more often atopic than unselected schoolchildren. Atopy was significantly more frequent and the onset of coeliac disease later for B8\/DR3- patients than B8\/DR3+ patients. There was no obvious relation between DR7 and atopy. It is concluded that atopy predisposes to coeliac disease partly independently of the HLA-DR3 associated disease susceptibility gene(s), and that different mechanisms may operate in the pathogenesis in coeliac disease patients with and without atopy.<\/jats:p>","DOI":"10.1136\/gut.24.4.306","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"306-310","source":"Crossref","is-referenced-by-count":36,"title":["HLA antigens and atopy in children with coeliac disease."],"prefix":"10.1136","volume":"24","author":[{"given":"M","family":"Verkasalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tiilikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Kuitunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Savilahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Backman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1983,4,1]]},"reference":[{"key":"ref_1","first-page":"115","article-title":"Hodson ME. Atopic disorders and adult coeliac disease","volume":"1","author":"AE, I.Hodgson H.J.F.Davies R.J.Gent","year":"1976","unstructured":"I Hodgson HJF. Davies RJ. Gent AE. Hodson ME. Atopic disorders and adult coeliac disease. Lancet 1976; 1: 115-7.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-94-011-8114-3_12","article-title":"On the association of coeliac disease with allergic disorders. A study of family histories of 11t) families with one or two children with coeliac disease","volume-title":"The genetics of coeliac disease","author":"Rossipal, E.","year":"1981","unstructured":"Rossipal E. On the association of coeliac disease with allergic disorders. A study of family histories of 11t) families with one or two children with coeliac disease. In: McConnell RB. ed. The genetics of coeliac disease. Lancaster: MTP Press. 1981: 85-92."},{"key":"ref_3","first-page":"162","article-title":"Histocompatibilitv antigens associated with adult coeliac disease","volume":"2","author":"WT, Stokes P.L.Asquith P.Holmes G.K.T.Mackintosh P.Cooke","year":"1972","unstructured":"Stokes PL. Asquith P. Holmes GKT. Mackintosh P. Cooke WT. Histocompatibilitv antigens associated with adult coeliac disease. Lancet 1972; 2: 162-4.","journal-title":"Lancet"},{"key":"ref_4","first-page":"506","article-title":"HLA-DRW3 association with coeliac disease","volume":"1","author":"van Leeuwen A. van Hoof JP. van Rood JJ, Keunig J.J.Pefna A.S.","year":"1976","unstructured":"Keunig JJ. Pefna AS. van Leeuwen A. van Hoof JP. van Rood JJ. HLA-DRW3 association with coeliac disease. Lancet 1976; 1: 506-1 1.","journal-title":"Lancet"},{"key":"ref_5","first-page":"123","article-title":"B-cell alloantigens in coeliac disease","volume-title":"Perspectives in coeliac disease","author":"R, Albert E.Harms K.Bertele","year":"1977","unstructured":"Albert E. Harms K. Bertele R et al. B-cell alloantigens in coeliac disease. In: McNicholl B. McCarthy CF. Fottrell PF. eds. Perspectives in coeliac disease. Lancaster: MTP Press. 1977: 123-9."},{"key":"ref_6","first-page":"3","article-title":"Two HLA-D and DR alleles are associated with coeliac disease","volume":"14","author":"DeMarchi, M.; ei al, Borelli I.Olivetti E.","year":"1979","unstructured":"DeMarchi M, Borelli I. Olivetti E ei al. Two HLA-D and DR alleles are associated with coeliac disease. Tissue Amitigens 1979; 14: 3t)9-16.","journal-title":"Tissue Amitigens"},{"key":"ref_7","first-page":"49","article-title":"HLA antigens in patients with juvenile diabetes mellitus. coeliac disease and both of these diseases","volume":"3","author":"HK, Koivisto V.A.Kuitunen P.Tiilikainen A.Akerbloni","year":"1977","unstructured":"Koivisto VA. Kuitunen P. Tiilikainen A. Akerbloni HK. HLA antigens in patients with juvenile diabetes mellitus. coeliac disease and both of these diseases. Diabete Metab 1977; 3: 49-53.","journal-title":"Diabete Metab"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2222.1979.tb01522.x","article-title":"The prevalence of allergic conditions and immediate skin test reactions among Finnish adolescents","volume":"9","author":"Haahtela, T.M.K.","year":"1979","unstructured":"Haahtela TMK. The prevalence of allergic conditions and immediate skin test reactions among Finnish adolescents. Clini Allergy 1979; 9: 53-60.","journal-title":"Clini Allergy"},{"key":"ref_9","first-page":"433","article-title":"Allergic disorders and immediate skin test reactivity in Finnish adolescents","volume-title":"Allerg","volume":"35","author":"I, Haahtela T.Heiskala M.Suoniemi","year":"1980","unstructured":"Haahtela T. Heiskala M. Suoniemi I. Allergic disorders and immediate skin test reactivity in Finnish adolescents. Allerg 1980; 35: 433-41."},{"key":"ref_10","first-page":"784","article-title":"A simplified micro double diffusion agar precipitin technique","volume":"52","author":"Crowle, A.J.","year":"1958","unstructured":"Crowle AJ. A simplified micro double diffusion agar precipitin technique. J Lab Clini Med 1958; 52: 784-7.","journal-title":"J Lab Clini Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1398-9995.1978.tb01522.x","article-title":"Standardization of allergen extracts with appropriate methods. The combined use of skin prick testing and radioallergosorbent tests","volume":"33","author":"L, Aas K.Backman A.Belin; B, Wecke","year":"1978","unstructured":"Aas K. Backman A. Belin L, Wecke B. Standardization of allergen extracts with appropriate methods. The combined use of skin prick testing and radioallergosorbent tests. Allergy 1978; 33: 130-7.","journal-title":"Allergy"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00007890-197905000-00003","article-title":"Stimulatory and cvtotoxic activity on human adult and fetal lymphocytes bv heterologous antihuman fetal lymphocyte sera","volume":"27","author":"de la Chapelle A, Tiilikainen A.","year":"1979","unstructured":"Tiilikainen A. de la Chapelle A. Stimulatory and cvtotoxic activity on human adult and fetal lymphocytes bv heterologous antihuman fetal lymphocyte sera. Transplamtation 1979; 27: 304-8.","journal-title":"Transplamtation"},{"key":"ref_13","first-page":"795","article-title":"Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants","volume":"262","author":"van Rood JJi van Leeuwen A. Ploem JS","year":"1976","unstructured":"van Rood JJi van Leeuwen A. Ploem JS. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Natu(re 1976; 262: 795-7.","journal-title":"Natu(re"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-662-38563-0_29","article-title":"Coeliakie - Klinik und Pathogenese","volume":"128","author":"Griittner, R.; Stern, M.","year":"1980","unstructured":"Griittner R, Stern M. Coeliakie - Klinik und Pathogenese. Mschr Kinderheilk 1980; 128: 109-17.","journal-title":"Mschr Kinderheilk"},{"key":"ref_15","first-page":"1285","article-title":"Intestinal permeability in patients with eczema and food allergy","volume":"1","author":"DM, Jackson P.G.Lessof M.H.Baker R.W.R.Ferrett J.MacDonald","year":"1981","unstructured":"Jackson PG. Lessof MH. Baker RWR. Ferrett J. MacDonald DM. Intestinal permeability in patients with eczema and food allergy. Lanicet 1981; 1: 1285-6.","journal-title":"Lanicet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/jnnp.39.1.23","article-title":"Genetic associations between mvasthenia gravis and the HL-A system","volume":"39","author":"Pirskanen, R.","year":"1976","unstructured":"Pirskanen R. Genetic associations between mvasthenia gravis and the HL-A system. J Neuirol Neuirosuirg Psvchiatr 1976; 39: 23-33.","journal-title":"J Neuirol Neuirosuirg Psvchiatr"},{"key":"ref_17","first-page":"169","article-title":"An immunologic if theory of glutensensitive enteropathy","volume-title":"Perspectives in coeliac disease","author":"Strober, W.","year":"1977","unstructured":"Strober W. An immunologic if theory of glutensensitive enteropathy. In: McNicholl B. McCarthv CF. Fottrell PF. eds. Perspectives in coeliac disease. Lancaster: MTP Press. 1977: 169-81."},{"key":"ref_18","article-title":"Clintical imtnunitology antd allergology","unstructured":"eds. Clintical imtnunitology antd allergology. Amsterdam: Elsevier\/North Holland Biomedical Press. 1981: 15766."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.4.306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:39:24Z","timestamp":1765658364000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.4.306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1983,4,1]]},"published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1136\/gut.24.4.306"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.4.306","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}