{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:17:57Z","timestamp":1788092277458,"version":"build-2803163510"},"reference-count":34,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p>A new method is described which allows simultaneous measurement of gastric emptying and duodenogastric reflux and avoids transpyloric intubation. After intragastric instillation of a liquid lipid meal in six healthy volunteers the fractional gastric emptying rate was 2.9 +\/- 0.3 in the upright and 2.5 +\/- 0.6 SEM X 10(-2)\/min in the supine position, respectively (p greater than 0.5). The duodenogastric reflux rate (expressed as fraction of the intraduodenal amount of duodenal marker) was 0.30 (range 0.03-0.81) and 0.22 (0.01-0.55) X 10(-2)\/min, respectively (p greater than 0.2). Atropine (40 micrograms\/kg) decreased the supine gastric emptying rate to 1.1 +\/- 0.2 (p less than 0.05) and increased the supine duodenogastric reflux rate to 2.74 (0.04-9.80) X 10(-2)\/min (p less than 0.05). Fasting duodenogastric reflux rate was similar in the supine and upright position, 0.49 (0.04-0.89) and 0.42 (0.06-0.97) X 10(-2)\/min, respectively (p greater than 0.5). Fractional gastric emptying rate was similar in 10 volunteers and 17 patients with type I gastric ulcer (2.1 +\/- 0.4 vs 1.7 +\/- 0.2 SEM X 10(-2)\/min, p greater than 0.2). Their duodenogastric reflux rates were also similar, 0.65 (0.01-5.24) vs 1.10 (0.01-10.83) X 10(-2)\/min (p greater than 0.5). We conclude therefore that (1) gastric emptying and both fasting and postprandial duodenogastric reflux are independent of the posture; (2) fasting and postprandial reflux are of similar magnitude; (3) atropine shows gastric emptying and increases duodenogastric reflux; and (4) patients with type I gastric ulcer have neither slowed gastric emptying nor increased duodenogastric reflux.<\/jats:p>","DOI":"10.1136\/gut.24.6.510","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"510-518","source":"Crossref","is-referenced-by-count":60,"title":["Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer."],"prefix":"10.1136","volume":"24","author":[{"given":"S A","family":"M\u00fcller-Lissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Fimmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sonnenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Will","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"M\u00fcller-Duysing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Heinzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Blum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1983,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/gut.12.7.552","article-title":"The effect of healing on bile reflux in gastric ulcer","volume":"12","author":"Black, R.B.; Roberts, G.; Rhodes, J.","year":"1971","unstructured":"Black RB, Roberts G, Rhodes J. 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Z Gastroenterol 1979; 4: 215-21."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/0016-5085(78)93271-7","article-title":"Gastric emptying in patients with gastric ulcer","volume":"74","author":"Morguelan, B.; Ippoliti, A.; Sturdevant, R.","year":"1979","unstructured":"Morguelan B, Ippoliti A, Sturdevant R. Gastric emptying in patients with gastric ulcer. (Abstract.) Gastroenterology 1979; 74: 1070.","journal-title":"(Abstract.) Gastroenterology"},{"key":"ref_29","first-page":"1135","article-title":"Bile acid and lysolecithin concentrations in the stomach of patients with gastric ulcer - before operation, after HSV and after partial gastrectomy","volume":"80","author":"Dewar, E.P.; King, R.F.G.J.; Johnston, D.","year":"1981","unstructured":"Dewar EP, King RFGJ, Johnston D. Bile acid and lysolecithin concentrations in the stomach of patients with gastric ulcer - before operation, after HSV and after partial gastrectomy. (Abstract.) 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