{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:22:14Z","timestamp":1771867334449,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>Seventy two patients admitted to a medical department with dyspepsia but without a previous diagnosis of peptic ulcer disease or chronic pancreatitis were studied consecutively. A pancreatic function test (Lundh meal test) and an upper endoscopy was made in all patients. There was no difference in age, sex ratio, occurrence of upper abdominal pain or chronic alcoholism between the groups of patients with reduced pancreatic function (20) and the group with normal function (52). Seven duodenal ulcers were found, two in patients with normal pancreatic function (2\/52 = 3.8%; 95% conf lim: 0.5-13.2) and five in patients with reduced pancreatic function (5\/20 = 25%; 95% conf lim: 8.7-49.1). This difference was statistically significant (p less than 0.01). Duodenitis occurred with equal frequency in the two groups.<\/jats:p>","DOI":"10.1136\/gut.24.9.781","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"781-783","source":"Crossref","is-referenced-by-count":28,"title":["Association between duodenal bulb ulceration and reduced exocrine pancreatic function."],"prefix":"10.1136","volume":"24","author":[{"given":"S","family":"Schulze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Thorsgaard Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"M\u00f8llmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Rune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"ref_1","first-page":"149","article-title":"Etude clinique et evolutive de 102 cas de pancreatite chronique","volume":"4","author":"Bernardes, P.; Callet, B.; Dupuy, R.","year":"1975","unstructured":"Bernardes P, Callet B, Dupuy R. Etude clinique et evolutive de 102 cas de pancreatite chronique. Nouv Presse Med 1975; 4: 149-52.","journal-title":"Nouv Presse Med"},{"key":"ref_2","first-page":"503","article-title":"Peptic ulcer diathesis in patients with chronic pancreatitis","volume":"51","author":"Dreiling, D.A.; Naqvi, M.A.","year":"1969","unstructured":"Dreiling DA, Naqvi MA. Peptic ulcer diathesis in patients with chronic pancreatitis. Am J Gastroenterol 1969; 51: 503-10.","journal-title":"Am J Gastroenterol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/gut.4.3.193","article-title":"A clinical study of chronic pancreatitis","volume":"4","year":"1963","unstructured":"Fitzgerald 0, Fitzgerald P, Fennelly J, McMullin JP, Boland SJ. A clinical study of chronic pancreatitis. Gut 1963; 4: 193-216.","journal-title":"Gut"},{"key":"ref_4","article-title":"Surgical diseases of the pancreas","author":"Howard, J.K.; Jordan, G.L.","unstructured":"Howard JK, Jordan GL. Surgical diseases of the pancreas. London: Pitman Medical Publishing, 1960: 211."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/bmj.2.5909.34","article-title":"Chronic pancreatitis in England: a changing picture?","volume":"2","author":"James 0, Agnew JE, Bouchier IAD","year":"1974","unstructured":"James 0, Agnew JE, Bouchier IAD. Chronic pancreatitis in England: a changing picture? Br Med J 1974; 2: 34-8.","journal-title":"Br Med J"},{"key":"ref_6","first-page":"1608","article-title":"Factors complicating observed associations between peptic ulcer and other diseases","volume":"68","author":"Donaldson, R.M.","year":"1975","unstructured":"Donaldson RM. Factors complicating observed associations between peptic ulcer and other diseases. Gastroenterology 1975; 68: 1608-14."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/00365526809180104","article-title":"pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with pancreatic diseases","volume":"3","author":"Worning, H.; Mullertz, S.; Hess Thaysen, E.; Bang, H.O.","year":"1968","unstructured":"Worning H, Mullertz S, Hess Thaysen E, Bang HO. pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with pancreatic diseases. Scand J Gastroenterol 1968; 3: 83-90.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","first-page":"45","volume":"16","author":"Venables, C.W.; Stephen, J.G.; Duodenitis, Lesna M.","year":"1980","unstructured":"Venables CW, Stephen JG, Lesna M. Duodenitis. Scand J Gastroenterol 1980; suppl 16: 45-55.","journal-title":"Scand J Gastroenterol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000197701","article-title":"The histological classification of duodenitis in fibreoptic specimens","volume":"13","author":"Whitehead, R.; Roca, M.; Meikle, D.D.; Skinner, J.; Truelove, S.C.","year":"1975","unstructured":"Whitehead R, Roca M, Meikle DD, Skinner J, Truelove SC. The histological classification of duodenitis in fibreoptic specimens. Digestion 1975; 13: 129-36.","journal-title":"Digestion"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/00365527109180704","article-title":"The pancreatic secretion of amylase as compared to the amylase concentration in the intestinal contents after ingestion of a meal","volume":"6","author":"Worning, H.","year":"1971","unstructured":"Worning H. The pancreatic secretion of amylase as compared to the amylase concentration in the intestinal contents after ingestion of a meal. Scand J Gastroenterol 1971; 6: 257-0.","journal-title":"Scand J Gastroenterol"},{"key":"ref_11","first-page":"835","article-title":"The Lundh test in the diagnosis of pancreatic disease: a review of five years'","volume":"14","author":"Mottaleb, A.; Kapp, F.; Noguera, E.C.A.; Kellock, T.D.; Wiggins, H.S.; Waller, S.L.","year":"1973","unstructured":"Mottaleb A, Kapp F, Noguera ECA, Kellock TD, Wiggins HS, Waller SL. The Lundh test in the diagnosis of pancreatic disease: a review of five years' experience. Gut 1973; 14: 835-41.","journal-title":"experience. Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/bmj.2.6134.392","article-title":"Disproportionate reduction in tryptic response to endogenous compared with exogenous stimulation in chronic pancreatitis","volume":"2","author":"Braganza, J.M.; Rao, J.J.","year":"1978","unstructured":"Braganza JM, Rao JJ. Disproportionate reduction in tryptic response to endogenous compared with exogenous stimulation in chronic pancreatitis. Br Med J 1978; 2: 392-4.","journal-title":"Br Med J"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/00365527809181745","article-title":"pH threshold for release of secretin in normal subjects and in patients with duodenal ulcer and patients with chronic pancreatitis","volume":"13","author":"Fahrenkrug, J.; Schaffalitzky de Muckadell, O.B.; Rune, S.J.","year":"1978","unstructured":"Fahrenkrug J, Schaffalitzky de Muckadell OB, Rune SJ. pH threshold for release of secretin in normal subjects and in patients with duodenal ulcer and patients with chronic pancreatitis. Scand J Gastroenterol 1978; 13: 177-86.","journal-title":"Scand J Gastroenterol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/BF01317211","article-title":"Impaired acid neutralization in the duodenum in pancreatic insufficiency","volume":"24","author":"Dutta, S.K.; Russell, R.M.; Fl, Iber","year":"1979","unstructured":"Dutta SK, Russell RM, Iber Fl. Impaired acid neutralization in the duodenum in pancreatic insufficiency. Dig Dis Sci 1979; 24: 775-80.","journal-title":"Dig Dis Sci"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/gut.20.3.249","article-title":"Postprandial gastric function in pancreatic insufficiency","volume":"20","author":"Regan, P.T.; Malagelada, J.-R.; Dimagno, E.P.; Go, V.L.W.","year":"1979","unstructured":"Regan PT, Malagelada J-R, Dimagno EP, Go VLW. Postprandial gastric function in pancreatic insufficiency. 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