{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:47:48Z","timestamp":1765601268605,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>A sensitivity to dietary cereal has been reported previously in niacin-deficient rats by measuring a change in the intestinal absorption of radioactively-labelled cellobiotol and mannitol. The possibility that other stimuli could produce this sensitivity, the range of cereals that could induce the permeability change and the nature of the toxic component in cereal have now all been investigated. Treatment with triparanol induces sensitivity in rats to wheat, rye, barley, oats, and maize but not to rice or soybean. These cereals caused a similar response in niacin-deficient rats. Mucosal damage produced by methotrexate or cetrimide, however, did not sensitise the intestinal mucosa to dietary cereals. Gluten, zein, and pepsin\/trypsin digests of gluten all induced the permeability defect in triparanol-treated rats. It is concluded that although gross disruption of the mucosal structure may not sensitise rats to cereals, various causes of mucosal cell damage can produce a susceptibility to gluten toxicity that resembles gluten-sensitivity in man.<\/jats:p>","DOI":"10.1136\/gut.24.9.825","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"825-830","source":"Crossref","is-referenced-by-count":6,"title":["Effect of dietary cereals on intestinal permeability in experimental enteropathy in rats."],"prefix":"10.1136","volume":"24","author":[{"given":"J S","family":"Sandhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"ref_1","first-page":"495","article-title":"The metabolic origin of trigonelline in the rat","year":"1981","unstructured":"Sandhu JS, Fraser DR. The metabolic origin of trigonelline in the rat. Biochem J 1981; 200: 495-500.","journal-title":"Biochem"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0016-5085(63)80097-9","article-title":"An acute malabsorption syndrome with reversible mucosal atrophy","volume":"44","author":"McPherson, JR, Summerskill; W.J.","year":"1963","unstructured":"McPherson JR, Summerskill WJ. An acute malabsorption syndrome with reversible mucosal atrophy. Gastroenterology 1963; 44: 900-4.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1007\/BF02233376","article-title":"Intestinal lesions associated with triparanol. A clinical and experimental study","volume":"10","author":"McPherson, JR, Shorter; R.G.","year":"1965","unstructured":"McPherson JR, Shorter RG. Intestinal lesions associated with triparanol. A clinical and experimental study. Am J Dig Dis 1965; 10: 1024-33.","journal-title":"Am J Dig Dis"},{"issue":"47","key":"ref_4","first-page":"202","article-title":"Tierexperimentelle Untersuchungen zur Frage der Spezifitat der Dunndarmschleimhautveranderung bei der einheimischen Sprue","volume":"1969","author":"Riecken, E.O.; Rosenbaum, R.; Bloch, R.; Menge, H.; Ritt, E.; Asslan, M.; Dolle, W.","unstructured":"Riecken EO, Rosenbaum R, Bloch R, Menge H, Ritt E, Asslan M, Dolle W. Tierexperimentelle Untersuchungen zur Frage der Spezifitat der Dunndarmschleimhautveranderung bei der einheimischen Sprue. Klin Wochenschr 1969; 47: 202-14.","journal-title":"Klin Wochenschr"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000197268","article-title":"Effect of gluten on glucose absorption from the small intestine in experimentally induced malabsorption in rats","volume":"7","author":"Bloch, R.; Menge, H.; Martini, G.A.; Riecken, E.O.","year":"1972","unstructured":"Bloch R, Menge H, Martini GA, Riecken EO. Effect of gluten on glucose absorption from the small intestine in experimentally induced malabsorption in rats. Digestion 1972; 7: 139-46.","journal-title":"Digestion"},{"key":"ref_6","first-page":"19","article-title":"Functional and biochemical evidence of damage to enterocytes induced by triparanol: role of lysosomes and the effect of a gluten-free diet","volume":"51","author":"Soule, J.-C.; Neale, G.; Peters, T.J.","year":"1976","unstructured":"Soule J-C, Neale G, Peters TJ. Functional and biochemical evidence of damage to enterocytes induced by triparanol: role of lysosomes and the effect of a gluten-free diet. Clin Sci Mol Med 1976; 51: 19-25.","journal-title":"Clin Sci Mol Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/cs0630311","article-title":"Assessment of intestinal permeability in the experimental rat with 133HJcellobiotol and ['4C]-mannitol","volume":"63","year":"1982","unstructured":"Sandhu JS, Fraser DR. Assessment of intestinal permeability in the experimental rat with 133HJcellobiotol and ['4C]-mannitol. Clin Sci 1982; 63: 311-316.","journal-title":"Clin Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3177\/jnsv.24.67","article-title":"Effect of nicotinic acid on catecholamine synthesis in rat brain","volume":"24","author":"Nakashima, Y.; Sanada, H.; Utsuki, Y.; Kawada, S.","year":"1978","unstructured":"Nakashima Y, Sanada H, Utsuki Y, Kawada S. Effect of nicotinic acid on catecholamine synthesis in rat brain. J Nutr Sci Vitaminol 1978; 24: 67-76.","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/cs0600115","article-title":"Passive permeability in experimental intestinal damage in rats","volume":"60","author":"Cobden, I.; Rothwell, J.; Axon, A.T.R.","year":"1981","unstructured":"Cobden I, Rothwell J, Axon ATR. Passive permeability in experimental intestinal damage in rats. Clin Sci 1981; 60: 115-8.","journal-title":"Clin Sci"},{"key":"ref_10","first-page":"252","article-title":"Gluten-induced enteropathy. The effect of partially digested gluten","volume":"2","author":"Frazer, A.C.; Fletcher, R.F.; Ross, C.A.C.; Shaw, B.; Sammons, H.C.; Schneider, R.","year":"1959","unstructured":"Frazer AC, Fletcher RF, Ross CAC, Shaw B, Sammons HC, Schneider R. Gluten-induced enteropathy. The effect of partially digested gluten. Lancet 1959; 2: 252-5.","journal-title":"Lancet"},{"key":"ref_11","first-page":"253","article-title":"Plant Biochemistry","author":"Bonner, J.","year":"1950","unstructured":"Bonner J. Plant Biochemistry 1st ed. New York: Academic Press, 1950: 253.","edition":"1st ed"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.9.825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:43:23Z","timestamp":1765601003000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.9.825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1983,9,1]]},"published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1136\/gut.24.9.825"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.9.825","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}