{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:34:47Z","timestamp":1765654487195,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>One hundred and forty six gastric ulcer patients were given open treatment using 1 g cimetidine daily to heal their ulcers. Of 130 who completed the acute treatment period of eight weeks, 112 (86%) had healed ulcers. Of these 112 patients with healed ulcers, 108 entered a one year double blind study to compare the effect of cimetidine maintenance therapy (400 mg at night) with placebo. Of the 84 patients available for assessment at the end of one year, 86% in the cimetidine treated group were in remission compared with 45% in the placebo treated group (chi 2 = 15.03; p less than 0.001). There were similar losses from non-compliance and drop out in both groups. The incidence of untoward effects and significant drug related laboratory abnormalities was low. The results indicate that cimetidine heals nearly 90% of acute gastric ulcers within eight weeks and that subsequent low dose maintenance treatment at night offers a considerable benefit over placebo therapy.<\/jats:p>","DOI":"10.1136\/gut.24.9.853","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"853-856","source":"Crossref","is-referenced-by-count":25,"title":["Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study."],"prefix":"10.1136","volume":"24","author":[{"given":"E","family":"Hentschel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sch\u00fctze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"R\u00fcdiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Judmair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Reichel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kerstan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/00365527909181411","article-title":"Maintenance treatment of duodenal ulcer patients with a single bedtime dose of cimetidine","volume":"14","author":"Berstad, A.; Aadland, E.; Carlsen, E.; Myren, J.; Semb, L.S.; Kruse-Jensen, A.","year":"1979","unstructured":"Berstad A, Aadland E, Carlsen E, Myren J, Semb LS, Kruse-Jensen A. Maintenance treatment of duodenal ulcer patients with a single bedtime dose of cimetidine. Scand J Gastroentol 1979; 14: 827-83.","journal-title":"Scand J Gastroentol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/pgmj.56.653.173","article-title":"Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study","volume":"56","author":"Burland, W.L.; Hawkins, B.W.; Beresford, J.","year":"1980","unstructured":"Burland WL, Hawkins BW, Beresford J. Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study. Postgrad Med J 1980; 56: 173-6.","journal-title":"Postgrad Med J"},{"key":"ref_3","article-title":"Cimetidine is effective in the treatment","volume-title":"of gastric ulcer. Gastroenterology 1978; 74: 1072","author":"Navert, H.; Larose, L.; Beaudry, R.","unstructured":"Navert H, Larose L, Beaudry R, et al. Cimetidine is effective in the treatment of gastric ulcer. Gastroenterology 1978; 74: 1072."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/00365527909179865","article-title":"Prophylactic effect of cimetidine in gastric ulcer patients","volume":"14","year":"1979","unstructured":"Jensen KB, Mollmann KM, Rahbek I, Madsen JR, Rune SJ, Wulff HR. Prophylactic effect of cimetidine in gastric ulcer patients. Scand J Gastroenterol 1979; 14: 175.","journal-title":"Scand J Gastroenterol"},{"key":"ref_5","first-page":"38","article-title":"Two year follow up after one differ from those on placebo except that they occur year's treatment with cimetidine or placebo. Lancet significantly less frequently. It appears from this","volume":"1","author":"Bodemar, G.; Walan, A.","year":"1980","unstructured":"Bodemar G, Walan A. Two year follow up after one differ from those on placebo except that they occur year's treatment with cimetidine or placebo. Lancet significantly less frequently. It appears from this 1980; 1: 38-9."},{"article-title":"A comparison between Caved-S and cimetidine in gastric ulcer treatment and subsequent maintenance therapy. (Abstract) Hepatogastroenterology (Suppl). Hamburg: XI Interthose at major risk from ulcer complications would national Congress of Gastroenterology, 1980. benefit most from long term maintenance therapy","author":"McAdam, W.A.F.; Pacsoo, C.; Morgan, A.G.","key":"ref_6","unstructured":"McAdam WAF, Pacsoo C, Morgan AG. A comparison between Caved-S and cimetidine in gastric ulcer treatment and subsequent maintenance therapy. (Abstract) Hepatogastroenterology (Suppl). Hamburg: XI Interthose at major risk from ulcer complications would national Congress of Gastroenterology, 1980. benefit most from long term maintenance therapy."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/gut.19.5.419","article-title":"Effect of ulcer healing on the prognosis of chronic References gastric ulcer","volume":"19","author":"Piper, D.W.; Shinners, J.; Greig, M.; Thomas, J.; Waller, S.L.","year":"1978","unstructured":"Piper DW, Shinners J, Greig M, Thomas J, Waller SL. Effect of ulcer healing on the prognosis of chronic References gastric ulcer. Gut 1978; 19: 419.","journal-title":"Gut"},{"key":"ref_8","first-page":"419","article-title":"Relapse rate of duodenal ulcer after cessation Hunter JO. Experience with cimetidine in the treatment of gastric ulceration","volume":"18","year":"1977","unstructured":"Ciclitira PJ, Machell RJ, Farthing MJ, Dick AP, 1 Korman MG, Hetzel DJ, Hansky J, Shearman DJC, Don G. Relapse rate of duodenal ulcer after cessation Hunter JO. Experience with cimetidine in the treatment of gastric ulceration. Gut 1977; 18: 419-20.","journal-title":"Gut"},{"key":"ref_9","first-page":"410","article-title":"Klingemann the treatment of benign gastric ulcer: a multicenter HG, Schubotz R. Long term treatment of duodenal double-blind study","volume":"74","author":"Massarrat, S.; Hausmann, L.; Heuser, E.","year":"1978","unstructured":"Massarrat S, Hausmann L, Heuser E, Klingemann the treatment of benign gastric ulcer: a multicenter HG, Schubotz R. Long term treatment of duodenal double-blind study. Gastroenterology 1978; 74: 410-5.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.24.9.853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:30:41Z","timestamp":1765654241000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.24.9.853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1983,9,1]]},"published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1136\/gut.24.9.853"],"URL":"https:\/\/doi.org\/10.1136\/gut.24.9.853","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}