{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:08:56Z","timestamp":1767704936374,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>This study examines which methods are most appropriate for preparation of the large bowel for double contrast barium enema. Two proprietary laxatives, X-Prep and Picolax, mechanical colonic lavage, and dietary restriction were evaluated in a randomised study of 160 patients. Four alternative preparations were compared with or without dietary restriction. The four preparations were X-Prep alone, X-Prep plus lavage, Picolax alone, and Picolax plus lavage. Scoring of the radiographs was carried out on a double blind basis. Picolax proved superior to X-Prep overall (p less than 0.01) but this was almost entirely because of its greater effect in the right colon and transverse colon. Cleansing in the left colon and rectosigmoid was similar with both laxatives. Restriction of solid food improved bowel cleansing and gave better results than mechanical lavage. The addition of a colonic lavage in starved patients did not significantly improve the quality of bowel preparation with either laxative.<\/jats:p>","DOI":"10.1136\/gut.25.1.69","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"69-72","source":"Crossref","is-referenced-by-count":20,"title":["Variables in the preparation of the large intestine for double contrast barium enema examination."],"prefix":"10.1136","volume":"25","author":[{"given":"J R","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Ferrando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0016-5085(76)80025-X","article-title":"The clean colon","volume":"70","author":"Miller, R.E.","year":"1976","unstructured":"Miller RE. The clean colon. Gastroenterology 1976; 70: 289-90.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0009-9260(81)80196-1","article-title":"A randomized trial to investigate X-Prep, oral mannitol and colonic washout for double contrast barium enema","volume":"32","author":"Lee, JR, Hares; MM, Keighley; M.R.B.","year":"1981","unstructured":"Lee JR, Hares MM, Keighley MRB. A randomized trial to investigate X-Prep, oral mannitol and colonic washout for double contrast barium enema. Clin Radiol 1981; 32: 591-4.","journal-title":"Clin Radiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/030006057700500515","article-title":"Preparation of the large bowel for endoscopy","volume":"5","author":"Teague, R.H.; Manning, A.P.","year":"1977","unstructured":"Teague RH, Manning AP. Preparation of the large bowel for endoscopy. J Int Med Res 1977; 5: 374-7.","journal-title":"J Int Med Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2214\/ajr.128.1.57","article-title":"An evaluation of colon cleansing regimes","volume":"128","author":"Dodds, W.J.; Scanlon, G.T.; Shaw, D.K.; Stewart, E.T.; Yorker, J.E.; Metty, G.E.","year":"1977","unstructured":"Dodds WJ, Scanlon GT, Shaw DK, Stewart ET, Yorker JE, Metty GE. An evaluation of colon cleansing regimes. -AJR 1977; 128: 57-9.","journal-title":"-AJR"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1148\/127.2.317","article-title":"The state of radiographic techniques in the examination of the colon: a survey","volume":"127","author":"Thoeni, R.E.; Margulis, R.","year":"1978","unstructured":"Thoeni RE, Margulis R. The state of radiographic techniques in the examination of the colon: a survey. Radiology 1978; 127: 317-23.","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1136\/bmj.284.6321.1021","article-title":"Routine colonic lavage is unnecessary for double contrast barium enema in outpatients","volume":"284","author":"G, De Lacey; M, Benson; R, Wilkins; J, Spencer; B, Cramer","year":"1982","unstructured":"De Lacey G, Benson M, Wilkins R, Spencer J, Cramer B. Routine colonic lavage is unnecessary for double contrast barium enema in outpatients. Br Med J 1982; 284: 1021-2.","journal-title":"Br Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0300-5089(21)00220-0","article-title":"Anti-diarrhoeal agents and laxatives: changing concepts","volume":"8","author":"Fingl, E.; Freston, J.W.","year":"1979","unstructured":"Fingl E, Freston JW. Anti-diarrhoeal agents and laxatives: changing concepts. Clin Gastroenterol 1979; 8: 161-85.","journal-title":"Clin Gastroenterol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.pa.17.040177.002035","article-title":"Pharmacology of laxatives","volume":"17","author":"Binder, H.J.","year":"1977","unstructured":"Binder HJ. Pharmacology of laxatives. Ann Rev Pharmacol Toxicol 1977; 17: 355-67.","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/gut.11.12.1038","article-title":"The action of Sennosides and related compounds on the human colon and rectum","volume":"11","author":"Hardcastle, T.D.; Wilkins, J.L.","year":"1970","unstructured":"Hardcastle TD, Wilkins JL. The action of Sennosides and related compounds on the human colon and rectum. Gut 1970; 11: 1038-42.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00501005","article-title":"The hydragogue and laxative effect of the sulphuric acid ester and the free diphenol of 4,4'dihydroxydiphenyl(pyridyl-2)-methane","volume":"274","author":"Forth, W.; Nell, G.; Rummel, W.; Andres, H.","year":"1972","unstructured":"Forth W, Nell G, Rummel W, Andres H. The hydragogue and laxative effect of the sulphuric acid ester and the free diphenol of 4,4'dihydroxydiphenyl(pyridyl-2)-methane. Naunyn-Schmiedebergs Arch Pharmacol 1972; 274: 46-53.","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"ref_11","first-page":"1796","article-title":"Bis-(phydroxyphenyl)-pyridyl- 2-methane: the common laxative principle of bisacodyl and sodium picosulphate","volume":"25","author":"Jauch, R.; Hawkwitz, R.; Beschke, K.; Pelzer, H.","year":"1975","unstructured":"Jauch R, Hawkwitz R, Beschke K, Pelzer H. Bis-(phydroxyphenyl)-pyridyl-2-methane: the common laxative principle of bisacodyl and sodium picosulphate. Arzneim Forsch 1975; 25: 1796-800.","journal-title":"Arzneim Forsch"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.1.69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:49:59Z","timestamp":1765597799000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.1.69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1984,1,1]]},"published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1136\/gut.25.1.69"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.1.69","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}