{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:40:24Z","timestamp":1765082424778,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>The relationship between intraoesophageal pH value and motor activity of the lower oesophageal body and sphincter was investigated by simultaneous evaluation of intraluminal pressure and pH in 13 patients complaining of heartburn and regurgitation. One hundred and thirty one episodes of gastro-oesophageal reflux were recorded. One hundred and eighteen (90.1%) were preceded by a swallow (one to 12 seconds), 13 reflux episodes (9.9%) were not preceded by a swallow. Gastro-oesophageal refluxes preceded by swallow were accompanied by an equal number of normal and abnormal primary peristaltic sequences and, while recording at level of the lower oesophageal sphincter, occurred during inhibition of the sphincter. Frequency of abnormal primary peristalsis increased (p less than 0.01) during periods of low intraluminal pH (less than 5.0). An increase of at least 0.5 U in intraluminal pH occurred with 45.2% of normal primary peristalsis, 29.3% of abnormal primary peristalsis, 4.3% of secondary peristalsis, 3.5% of non-peristaltic contractions. The results of this study indicate that in patients with symptoms of reflux oesophagitis, gastro-oesophageal reflux appears to be related to swallow-induced lower oesophageal sphincter inhibition and not related to abnormal motor activity of the distal oesophageal body where an increased frequency of abnormal primary peristalsis appears to occur during low intraluminal pH and primary peristalsis appears to be the most important mechanism of oesophageal clearing.<\/jats:p>","DOI":"10.1136\/gut.25.1.7","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"7-13","source":"Crossref","is-referenced-by-count":33,"title":["Motor activity of the distal oesophagus and gastrooesophageal reflux."],"prefix":"10.1136","volume":"25","author":[{"given":"E","family":"Corazziari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Bontempo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Anzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Torsoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"ref_1","article-title":"Mechanisms of gastroesophageal reflux (GER) in patients with reflux esophagitis","volume-title":"[Abstract.] Gastroenterology 1979; 5: 1153","author":"Hauser, R.; Dodds, W.J.; Patel, G.K.; Dent, J.; Hogan, W.J.; Arndorfer, R.C.","unstructured":"Hauser R, Dodds WJ, Patel GK, Dent J, Hogan WJ, Arndorfer RC. Mechanisms of gastroesophageal reflux (GER) in patients with reflux esophagitis. [Abstract.] Gastroenterology 1979; 5: 1153."},{"key":"ref_2","first-page":"256","article-title":"spontaneous lower oesophageal sphincter","volume":"65","author":"Dent, J.; Dodds, W.J.; Friedman, R.H.","year":"1980","unstructured":"spontaneous lower oesophageal sphincter 2 Dent J, Dodds WJ, Friedman RH et al. Mechanisms of relaxation.2 In the present study swallow-induced gastroesophageal reflux in recumbent asymptomatic gastro-oesophageal reflux was associated with an human subjects. J Clin Invest 1980; 65: 256-7.","journal-title":"J Clin Invest; Mechanisms of relaxation.2 In the present study swallow-induced gastroesophageal reflux in recumbent asymptomatic gastro-oesophageal reflux was associated with an human subjects"},{"key":"ref_3","first-page":"1267","article-title":"Fluid mechanics of control of reflux","volume":"2","author":"Johnson, H.D.","year":"1966","unstructured":"Johnson HD. Fluid mechanics of control of reflux. Lancet 1966; 2: 1267-8.","journal-title":"Lancet"},{"issue":"129","key":"ref_4","first-page":"734","article-title":"Pressure relationship responsible for reflux in patients with hiatal hernia","volume":"1969","author":"Longhi, E.H.; Jordan, P.H.","unstructured":"Longhi EH, Jordan PH. Pressure relationship responsible for reflux in patients with hiatal hernia. Surg Gynecol Obstet 1969; 129: 734-48.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_5","first-page":"602","article-title":"Pressure and potential difference characteristics of surgically created canine hiatal hernia. Gastromotor activity. Dent et a12 could not detect any enterology","volume":"48","author":"Greenwood, R.K.; Schlegel, J.F.; Helm, W.J.; Code, C.F.","year":"1965","unstructured":"Greenwood RK, Schlegel JF, Helm WJ, Code CF. Pressure and potential difference characteristics of surgically created canine hiatal hernia. Gastromotor activity. Dent et a12 could not detect any enterology 1965; 48: 602-10."},{"key":"ref_6","first-page":"431","article-title":"Esophageal motor disfunction linked to occurrence of reflux in children","author":"Dent, J.; Davidson, G.P.; Kirubakarin, C.; Barnes, B.E.","year":"1981","unstructured":"Dent J, Davidson GP, Kirubakarin C, Barnes BE. Esophageal motor disfunction linked to occurrence of reflux in children. Z Gastroenterol 1981; 19(9): 431.","journal-title":"Z Gastroenterol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-3476(80)80482-3","article-title":"Mechanisms of gastroesophageal reflux in children","volume":"97","author":"Werlin, S.L.; Dodds, W.J.; Hogan, W.J.; Arndorfer, R.C.","year":"1980","unstructured":"Werlin SL, Dodds WJ, Hogan WJ, Arndorfer RC. Mechanisms of gastroesophageal reflux in children. J Pediatr 1980; 97: 244-9.","journal-title":"J Pediatr"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1172\/JCI104760","article-title":"Esophageal motor abnormalities induced by acid perfusion in patients with heartburn","volume":"42","author":"Siegel, C.I.; Hendrix, T.R.","year":"1963","unstructured":"Siegel CI, Hendrix TR. Esophageal motor abnormalities induced by acid perfusion in patients with heartburn. J Clin Invest 1963; 42: 686-95.","journal-title":"J Clin Invest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1148\/87.2.220","article-title":"Acid barium swallow in the radiographic evaluation of clinical esophagitis","volume":"87","author":"Donner, M.W.; Silbiger, M.L.; Hookman, P.","year":"1966","unstructured":"Donner MW, Silbiger ML, Hookman P. Acid barium swallow in the radiographic evaluation of clinical esophagitis. Radiology 1966; 87: 220-5.","journal-title":"Radiology"},{"key":"ref_10","first-page":"1","article-title":"A comparison of clinical measurement","volume-title":"of gastroesophageal reflux. Gastroenterology 1972; 62","author":"Benz, L.J.; Hootkin, L.A.; Margulies, S.; Donner, M.W.; Gauthorne, R.T.; Hendrix, T.R.","unstructured":"Benz LJ, Hootkin LA, Margulies S, Donner MW, Gauthorne RT, Hendrix TR. A comparison of clinical measurement of gastroesophageal reflux. Gastroenterology 1972; 62: 1-5."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.1.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:02:49Z","timestamp":1765076569000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.1.7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1984,1,1]]},"published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1136\/gut.25.1.7"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.1.7","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}