{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:35:43Z","timestamp":1770964543682,"version":"3.50.1"},"reference-count":27,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:p>We have studied nocturnal acid secretion in patients with duodenal ulcer who met predetermined criteria of poor clinical response to cimetidine. Different groups of patients were investigated receiving either no treatment, cimetidine 1 g\/day, cimetidine 2 g\/day or cimetidine 1 g\/day combined with atropine 4.8 mg\/day. The results were compared with those obtained from other patients with duodenal ulcer who were studied in our department but who were not classified as according to their clinical response to cimetidine. The results show that despite adequate absorption, cimetidine has a decreased effect at controlling acid secretion in the poor responders and that increasing the dose of drug does not improve response. Control of acid output was, however, dramatically improved when cimetidine was combined with atropine which suggests that patients who do not respond to H2-receptor blockade should be treated by a combination of cimetidine with an anticholinergic agent.<\/jats:p>","DOI":"10.1136\/gut.25.11.1211","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1211-1216","source":"Crossref","is-referenced-by-count":36,"title":["Effect of no treatment, cimetidine 1 g\/day, cimetidine 2 g\/day and cimetidine combined with atropine on nocturnal gastric secretion in cimetidine non-responders."],"prefix":"10.1136","volume":"25","author":[{"given":"T","family":"Gledhill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,11,1]]},"reference":[{"key":"ref_1","first-page":"33","article-title":"Use and abuse of H2-receptor antagonists","volume":"16","author":"Hunt, R.H.","year":"1982","unstructured":"Hunt RH. Use and abuse of H2-receptor antagonists. J R Coll Physicians 1982; 16: 33-9.","journal-title":"J R Coll Physicians"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/bmj.281.6232.20","article-title":"Intermittent treatment of duodenal ulcer with cimetidine","volume":"11","author":"Bardhan, K.D.","year":"1980","unstructured":"Bardhan KD. Intermittent treatment of duodenal ulcer with cimetidine. Br Med J 1980; 11: 20-2.","journal-title":"Br Med J"},{"key":"ref_3","first-page":"34","article-title":"Nonresponders to cimetidine. Baron JH, ed. Cimetidine in the 80's","author":"Hunt, R.H.","year":"1981","unstructured":"Hunt RH. Nonresponders to cimetidine. Baron JH, ed. Cimetidine in the 80's. Edinburgh: Churchill Livingstone, 1981: 34-41."},{"key":"ref_4","first-page":"451","article-title":"Interactions of an antimuscarinic and an H2-receptor antagonising drug in man [Abstract]","volume-title":"Gut","volume":"21","author":"Londong, W.; Londong, V.; Weber, T.H.; Von Werde, K.","year":"1980","unstructured":"Londong W, Londong V, Weber TH, Von Werde K. Interactions of an antimuscarinic and an H2-receptor antagonising drug in man [Abstract] Gut 1980; 21: A451."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/gut.17.2.133","article-title":"Effect of cimetidine on twenty-four hour intragastric acidity in normal subjects","volume":"17","author":"Pounder, R.E.; Williams, J.G.; Milton-Thompson, G.J.; Misiewicz, J.J.","year":"1976","unstructured":"Pounder RE, Williams JG, Milton-Thompson GJ, Misiewicz JJ. Effect of cimetidine on twenty-four hour intragastric acidity in normal subjects. Gut 1976; 17: 133-8.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/jps.2600660825","article-title":"High pressure liquid chromatographic analysis of cimetidine the histamine H2-receptor antagonist in blood and urine","volume":"66","author":"Randolph, W.C.; Osborne, V.L.; Walkenstein, S.S.","year":"1977","unstructured":"Randolph WC, Osborne VL, Walkenstein SS et al. High pressure liquid chromatographic analysis of cimetidine the histamine H2-receptor antagonist in blood and urine. J Pharm Sci 1977; 66: 1148-50.","journal-title":"J Pharm Sci"},{"key":"ref_7","first-page":"243","article-title":"Ranitidine treatment of cimetidine-resistant peptic ulcers: preliminary clinical and 24 hour intragastric acidity results","volume-title":"The clinical use of ranitidine","author":"Galmiche, J.P.; Deschalliers, J.P.; Denis, P.; Chevallier, B.; Colin, R.","year":"1982","unstructured":"Galmiche JP, Deschalliers JP, Denis P, Chevallier B, Colin R. Ranitidine treatment of cimetidine-resistant peptic ulcers: preliminary clinical and 24 hour intragastric acidity results. In: Misiewicz JJ, Wormsley KG, eds. The clinical use of ranitidine. Oxford: Medicine Publishing Foundation, 1982: 243-50."},{"key":"ref_8","series-title":"Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists","first-page":"145","article-title":"Effect of cimetidine in gastric emptying","author":"Heading, R.C.; Logan, R.F.A.; McLoughlin, G.P.; Lidgard, G.; Forrest, J.A.H.","year":"1977","unstructured":"Heading RC, Logan RFA, McLoughlin GP, Lidgard G, Forrest JAH. Effect of cimetidine in gastric emptying. In: Burland WL, Simpkins MA, eds. Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists. Amsterdam: Excerpta Medica, 1977: 145-54."},{"key":"ref_9","series-title":"Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists","first-page":"124","article-title":"Nocturnal gastric acid secretion: effect of cimetidine and interaction with anticholinergics","author":"Blackwood, W.S.; Northfield, T.C.","year":"1977","unstructured":"Blackwood WS, Northfield TC. Nocturnal gastric acid secretion: effect of cimetidine and interaction with anticholinergics. In: Burland WL, Simpkins MA, eds. Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists. Amsterdam: Excerpta Medica, 1977: 124-30."},{"key":"ref_10","series-title":"Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists","first-page":"254","article-title":"Cimetidine in the treatment of duodenal ulcer","author":"Peter, P.; Fritsch, W.P.; Nieschlag, E.; Wrenbeck, M.; Strohmeyer, B.","year":"1977","unstructured":"Peter P, Fritsch WP, Nieschlag E, Wrenbeck M, Strohmeyer B. Cimetidine in the treatment of duodenal ulcer. In: Burland WL, Simpkins MA, eds. Cimetidine. Proceedings of the second international symposium on histamine H2-receptor antagonists. Amsterdam: Excerpta Medica, 1977: 254-9."},{"key":"ref_11","first-page":"174","article-title":"Cimetidine in duodenal ulcer: controlled trial","volume":"2","author":"Blackwood, W.S.; Maugdal, D.P.; Pickard, R.G.; Lawrence, D.; Northfield, T.C.","year":"1976","unstructured":"Blackwood WS, Maugdal DP, Pickard RG, Lawrence D, Northfield TC. Cimetidine in duodenal ulcer: controlled trial. Lancet 1976; 2: 174-6.","journal-title":"Lancet"},{"key":"ref_12","series-title":"Cimetidine. Proceedings of the second international symposium on histamine H2receptor antagonists","first-page":"224","article-title":"Cimetidine in the treatment of active peptic ulcer disease","author":"Bodemar, G.; Norlander, B.; Walan, A.","year":"1977","unstructured":"Bodemar G, Norlander B, Walan A. Cimetidine in the treatment of active peptic ulcer disease. In: Burland WL, Simpkins MA, eds. Cimetidine. Proceedings of the second international symposium on histamine H2receptor antagonists. Amsterdam: Excerpta Medica, 1977: 224-39."},{"key":"ref_13","first-page":"31","article-title":"Cimetidine in duodenal ulceration","volume-title":"Cimetidine. The Westminster Hospital symposium","author":"Bardhan, K.D.","year":"1978","unstructured":"Bardhan KD. Cimetidine in duodenal ulceration. In: Wastell C, Lance P, eds. Cimetidine. The Westminster Hospital symposium. Edinburgh: Churchill Livingstone, 1978: 31-56."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/gut.22.4.319","article-title":"Comparison of twice daily ranitidine with standard cimetidine treatment of duodenal ulcer","volume":"22","author":"Walt, R.P.; Trotman, I.F.; Frost, R.","year":"1981","unstructured":"Walt RP, Trotman IF, Frost R et al. Comparison of twice daily ranitidine with standard cimetidine treatment of duodenal ulcer. 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Gastroenterology 1980; 79: 4-10.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0016-5085(79)80071-2","article-title":"Reduction of twentyfour hour gastric acidity with combination drug therapy in patients with duodenal ulcer","volume":"77","author":"Peterson, W.L.; Barnett, C.; Feldman, M.; Richardson, C.T.","year":"1979","unstructured":"Peterson WL, Barnett C, Feldman M, Richardson CT. Reduction of twentyfour hour gastric acidity with combination drug therapy in patients with duodenal ulcer. Gastroenterology 1979; 77: 1015-20.","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1056\/NEJM197712292972603","article-title":"Effect of low dose propantheline on food stimulated gastric acid secretion. Comparison of an \"Optimal effective Dose\"","volume":"297","author":"Feldman, M.; Richardson, C.T.; Peterson, W.L.; Walsh, J.H.; Fordtran, J.S.","year":"1977","unstructured":"Feldman M, Richardson CT, Peterson WL, Walsh JH, Fordtran JS. Effect of low dose propantheline on food stimulated gastric acid secretion. Comparison of an \"Optimal effective Dose\" and interaction with cimetidine. N Engl J Med 1977; 297: 1427-30.","journal-title":"Engl J Med"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/gut.18.2.85","article-title":"Vincent SH, MiltonThompson GJ. Twenty four hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine","volume":"18","author":"Pounder, R.E.; Hunt, R.H.","year":"1977","unstructured":"Pounder RE, Hunt RH, Vincent SH, MiltonThompson GJ. 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Gut 1981; 22: 49-54."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1185\/03007998109112368","article-title":"The treatment of 'Cimetidine resistant' peptic ulcers by ranitidine hydrochloride - a new histamine H2-receptor antagonist","volume":"7","author":"Mohammed, R.; Mitchell, K.G.; Mackay, C.","year":"1981","unstructured":"Mohammed R, Mitchell KG, Mackay C. The treatment of 'Cimetidine resistant' peptic ulcers by ranitidine hydrochloride - a new histamine H2-receptor antagonist. Curr Med Res Opin 1981; 7: 523-5.","journal-title":"Curr Med Res Opin"},{"key":"ref_25","first-page":"254","article-title":"Ranitidine in the treatment of cimetidine resistant ulcers of the upper intestinal tract","volume-title":"The clinical use of ranitidine","author":"Brunner, G.; Logen, H.; Harke, U.","year":"1982","unstructured":"Brunner G, Logen H, Harke U. Ranitidine in the treatment of cimetidine resistant ulcers of the upper intestinal tract. In: Misiewicz JJ, Wormsley KG, eds. The clinical use of ranitidine. Oxford: Medicine Publishing Foundation, 1982: 254-6."},{"key":"ref_26","first-page":"2077","article-title":"Behandling cimetidine resistenter ulcera duodeni mit der neuen H2-receptor antagonister ranitidine","volume":"32","author":"Schultz, E.","year":"1982","unstructured":"Schultz E. Behandling cimetidine resistenter ulcera duodeni mit der neuen H2-receptor antagonister ranitidine. Therapiewock 1982; 32: 2077-8.","journal-title":"Therapiewock"},{"key":"ref_27","first-page":"1035","article-title":"Beneficial effects of pirenzepine, a selective anticholinergic agent in patients with Zollinger Ellison Syndrome (ZES)","volume":"82","author":"Collen, M.J.; Pardol, S.J.; Raufman, J.P.","year":"1982","unstructured":"Collen MJ, Pardol SJ, Raufman JP et al. Beneficial effects of pirenzepine, a selective anticholinergic agent in patients with Zollinger Ellison Syndrome (ZES). Gastroenterology 1982; 82: 1035.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.11.1211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:21:10Z","timestamp":1765635670000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.11.1211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1984,11,1]]},"published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1136\/gut.25.11.1211"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.11.1211","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}