{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:08:04Z","timestamp":1764997684632,"version":"3.46.0"},"reference-count":8,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:p>We pursued the possibility that Mycobacterium kansasii might be an aetiological agent in Crohn's disease by carrying out a trial of treatment with antimycobacterial drugs. Twenty seven patients with Crohn's disease took part in a two year randomised double blind, crossover, controlled trial of rifampicin plus ethambutol against placebo. Fourteen patients completed the trial; four required an operation; five were withdrawn as poor compliers, and four because of adverse effects. There was no significant difference in response to the active drugs compared with placebo when expressed in terms of a Crohn's disease activity index or any clinical indicator of disease activity. There was no suggestion that any subgroup of patients - for example, different regions of bowel affected or previous operation - were favourably affected by the drugs. There was no consistent pattern of change in prednisolone requirements although eight patients on long term sulphasalazine had a significant reduction in their plasma sulphapyridine concentrations during the active treatment period. A significant reduction in total white blood count and an increase in plasma ALT were seen during active therapy. The results of the study do not suggest that rifampicin and ethambutol have a role to play in the treatment of Crohn's disease.<\/jats:p>","DOI":"10.1136\/gut.25.2.203","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"203-205","source":"Crossref","is-referenced-by-count":75,"title":["Controlled trial of rifampicin and ethambutol in Crohn's disease."],"prefix":"10.1136","volume":"25","author":[{"given":"J L","family":"Shaffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B D","family":"Linaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L A","family":"Turnberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,2,1]]},"reference":[{"key":"ref_1","first-page":"693","article-title":"Mycobacteria as a possible cause of inflammatory bowel disease","volume":"2","author":"Burnham, W.R.; Lennard-Jones, J.E.; Stanford, T.L.; Bird, R.G.","year":"1978","unstructured":"Burnham WR, Lennard-Jones JE, Stanford TL, Bird RG. Mycobacteria as a possible cause of inflammatory bowel disease. Lancet 1978; 2: 693-6.","journal-title":"Lancet"},{"key":"ref_2","first-page":"944","volume-title":"Sarcoidosis and Crohn's disease. Proc Roy Soc Med","volume":"64","author":"Mitchell, D.N.; Rees, R.J.W.","year":"1971","unstructured":"Mitchell DN, Rees RJW. Sarcoidosis and Crohn's disease. Proc Roy Soc Med 1971; 64: 944-5."},{"key":"ref_3","first-page":"1120","article-title":"Further animal evidence of a transmissable agent in Crohn's disease","volume":"2","author":"Cave, D.R.; Mitchell, D.N.; Kane, S.P.; Brooke, B.N.","year":"1973","unstructured":"Cave DR, Mitchell DN, Kane SP, Brooke BN. Further animal evidence of a transmissable agent in Crohn's disease. Lancet 1973; 2: 1120-2.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/gut.18.5.360","article-title":"Evidence for a transmissable factor in Crohn's disease","volume":"18","author":"Donelly, B.J.; Delaney, P.V.; Healy, T.M.","year":"1977","unstructured":"Donelly BJ, Delaney PV, Healy TM. Evidence for a transmissable factor in Crohn's disease. Gut 1977; 18: 360-3.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn's disease activity index","volume":"70","author":"Best, W.R.; Becktel, J.M.; Singleton, J.W.; Kern, F.","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F. Development of a Crohn's disease activity index. Gastroenterology 1976; 70: 439-44.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/bmj.1.6159.306","article-title":"Rifampicin-induced non-responsiveness to corticosteroid treatment in nephrotic syndrome","volume":"1","author":"Hendrickse, W.; McKiernan, J.; Pickup, M.E.; Lowe, J.","year":"1979","unstructured":"Hendrickse W, McKiernan J, Pickup ME, Lowe J. Rifampicin-induced non-responsiveness to corticosteroid treatment in nephrotic syndrome. Br Med J 1979; 1: 306.","journal-title":"Br Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000198703","article-title":"Sulphadoxinepyrimethamine therapy in Crohn's disease","volume":"23","author":"Elliot, P.R.; Burnham, W.R.; Berghouse, L.M.; LennardJones, J.E.; Langman, M.J.S.","year":"1982","unstructured":"Elliot PR, Burnham WR, Berghouse LM, LennardJones JE, Langman MJS. Sulphadoxinepyrimethamine therapy in Crohn's disease. Digestion 1982; 23: 132-4.","journal-title":"Digestion"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2125.1982.tb01997.x","article-title":"Azo reduction of sulphasalazine in healthy volunteers","volume":"14","author":"Houston, J.B.; Day, J.; Walker, J.","year":"1982","unstructured":"Houston JB, Day J, Walker J. Azo reduction of sulphasalazine in healthy volunteers. Br J Clin Pharmacol 1982; 14: 395-8.","journal-title":"Br J Clin Pharmacol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.2.203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:03:04Z","timestamp":1764997384000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.2.203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1984,2,1]]},"published-print":{"date-parts":[[1984,2]]}},"alternative-id":["10.1136\/gut.25.2.203"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.2.203","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,2]]}}}