{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:12:10Z","timestamp":1768680730695,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p>The microvasculature was investigated in the normal bowel (n = 43 patients) and in radiation bowel disease (n = 18 patients). Tissue samples obtained from postoperative colectomy specimens in which the intramural vessels had been perfused with barium sulphate suspension were examined. Microradiography was used to study vascular pattern which was abnormal in radiation bowel disease. A recently described radiograph fluorescence system was used to estimate barium concentration, and hence microvascular volume. The radiation group showed a highly significant reduction in barium concentration (p less than 0.001), when compared with the normal group. This reduction was diffuse in samples from 15 patients who had received combined intracavity and external radiotherapy, but localised in two patients who had received intracavity treatment only. It is concluded that microvascular compromise is an important factor in the natural history of radiation bowel disease.<\/jats:p>","DOI":"10.1136\/gut.25.5.448","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T20:55:35Z","timestamp":1189198535000},"page":"448-454","source":"Crossref","is-referenced-by-count":82,"title":["Microvascular studies in human radiation bowel disease."],"prefix":"10.1136","volume":"25","author":[{"given":"N D","family":"Carr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B R","family":"Pullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Hasleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P F","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,5,1]]},"reference":[{"key":"ref_1","first-page":"181","article-title":"The radiationinjured bowel","volume":"11","author":"Localio, S.A.; Pachter, H.L.; Gouge, T.H.","year":"1979","unstructured":"Localio SA, Pachter HL, Gouge TH. 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New York: Excerpta Medica Foundation, 1968: 385-95."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3109\/00365528209181111","article-title":"Microangiographic pattern in the small intestine of the cat after irradiation","volume":"7","author":"Eriksson, B.","year":"1982","unstructured":"Eriksson B. Microangiographic pattern in the small intestine of the cat after irradiation. Scand J Gastroenterol 1982; 7: 887-95.","journal-title":"Scand J Gastroenterol"},{"key":"ref_7","article-title":"A simple method for the estimation of microvascular volume in tissue samples","author":"Carr, N.D.; Schofield, P.F.; Pullan, B.R.","year":"1984","unstructured":"Carr ND, Schofield PF, Pullan BR. A simple method for the estimation of microvascular volume in tissue samples. J Clin Phys Physiol Meas 1984. (In press.)","journal-title":"J Clin Phys Physiol Meas"},{"key":"ref_8","first-page":"683","volume-title":"Bowel damage from radiation. Proc R Soc Med","volume":"69","author":"Jackson, B.T.","year":"1976","unstructured":"Jackson BT. Bowel damage from radiation. Proc R Soc Med 1976; 69: 683-6."},{"key":"ref_9","first-page":"953","article-title":"Intestinal stenosis following radiation therapy","volume":"88","author":"Perkins, D.F.; Spjut, H.J.","year":"1962","unstructured":"Perkins DF, Spjut HJ. Intestinal stenosis following radiation therapy. Am J Radiol 1962; 88: 953-66.","journal-title":"Am J Radiol"},{"key":"ref_10","first-page":"476","article-title":"Mesenteric angiography in patients with radiation injury of the bowel after pelvic radiation","volume":"114","author":"Denker, H.; Lunderquist, Holmdow K.H.; A.","year":"1972","unstructured":"Denker H, Holmdow KH. Lunderquist A et al. Mesenteric angiography in patients with radiation injury of the bowel after pelvic radiation. Am J Radiol 1972; 114: 476-81.","journal-title":"Am J Radiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02553186","article-title":"Gastrointestinal complications after therapeutic irradiation","volume":"14","year":"1971","unstructured":"Kott I, Luca 1. Kesler H. Gastrointestinal complications after therapeutic irradiation. Dis Colon Rectum 1971; 14: 200-5.","journal-title":"Dis Colon Rectum"},{"key":"ref_12","article-title":"Focal ischaemia of the small intestine. In: Intestinal ischaemia","author":"Marston, A.","unstructured":"Marston A. Focal ischaemia of the small intestine. In: Intestinal ischaemia. London: Arnold, 1977: 136."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3109\/02841867609131978","article-title":"Bladder and intestinal injuries following radiation therapy of carcinoma of the uterine cervix","volume":"15","author":"Johnson, J.E.","year":"1976","unstructured":"Johnson JE. Bladder and intestinal injuries following radiation therapy of carcinoma of the uterine cervix. Acta Rad Ther Phys Biol 1976; 15: 541-5.","journal-title":"Acta Rad Ther Phys Biol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00004836-197903000-00003","article-title":"Effects of radiation on human intestinal tract","volume":"1","author":"Novak, J.M.; Collins, J.T.; Donowitz, M.","year":"1979","unstructured":"Novak JM, Collins JT, Donowitz M et al. Effects of radiation on human intestinal tract. J Clin Gastroenterol 1979; 1: 9-16.","journal-title":"J Clin Gastroenterol"},{"key":"ref_15","first-page":"1019","article-title":"Clinicopathological aspects of actinic enteritis","volume":"119","author":"Schier, J.; Dahlin, Symmonds R.F.; D.C.","year":"1964","unstructured":"Schier J, Symmonds RF. Dahlin DC. Clinicopathological aspects of actinic enteritis. Surg Gynecol Obstet 1964; 119: 1019-22.","journal-title":"Surg Gynecol Obstet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.5.448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:05:38Z","timestamp":1765602338000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.5.448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1984,5,1]]},"published-print":{"date-parts":[[1984,5]]}},"alternative-id":["10.1136\/gut.25.5.448"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.5.448","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}