{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:27:54Z","timestamp":1765610874653,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,6]]},"abstract":"<jats:p>In in vitro and in vivo systems, native or ricin conjugated monoclonal anti-HBs, are capable of inhibiting or slowing the growth of Alexander primary hepatocellular carcinoma cells. Failure of the immune response to this component of the hepatitis B virus may be one permissive factor in the development of some primary liver cell carcinoma in chronic HBV carriers.<\/jats:p>","DOI":"10.1136\/gut.25.6.619","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"619-623","source":"Crossref","is-referenced-by-count":9,"title":["In vitro and in vivo cytotoxic activity of native and ricin conjugated monoclonal antibodies to HBs antigen for Alexander primary liver cell carcinoma cells and tumours."],"prefix":"10.1136","volume":"25","author":[{"given":"J M","family":"Oladapo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Goodall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H C","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,6,1]]},"reference":[{"key":"ref_1","article-title":"The natural history of hepatitis B virus infection: impact of molecular biology","volume-title":"Recent advances in medicine","author":"Thomas, H.C.; Monjardino, J.","year":"1983","unstructured":"Thomas HC, Monjardino J. The natural history of hepatitis B virus infection: impact of molecular biology. In Recent advances in medicine. London: Butterworth, 1983."},{"key":"ref_2","first-page":"1006","article-title":"Induction of remission in hepatocellular carcinoma with Doxorubicin","volume":"1","author":"Johnson, P.J.; Thomas, H.C.; Williams, R.; Sherlock, S.; Murray-Lyon, I.M.","year":"1978","unstructured":"Johnson PJ, Thomas HC, Williams R, Sherlock S, Murray-Lyon IM. Induction of remission in hepatocellular carcinoma with Doxorubicin. Lancet 1978; 1: 1006-9.","journal-title":"Lancet"},{"key":"ref_3","first-page":"528","article-title":"Hepatitis B surface antigen and alphafetoprotein secreting human primary liver cell cancer","volume-title":"athymic mice. Gastroenterology 1980; 79","author":"Bassendine, M.F.; Arborgh, B.A.M.; Shipton, U.","unstructured":"Bassendine MF, Arborgh BAM, Shipton U et al. Hepatitis B surface antigen and alphafetoprotein secreting human primary liver cell cancer in athymic mice. Gastroenterology 1980; 79: 528-32."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1042\/cs0640643","article-title":"Growth characteristics of alphafetoprotein secreting human hepatocellular carcinoma in athymic (nude) mice","volume":"64","author":"Bassendine, M.F.; Wright, N.A.; Thomas, H.C.; Sherlock, S.","year":"1983","unstructured":"Bassendine MF, Wright NA, Thomas HC, Sherlock S. Growth characteristics of alphafetoprotein secreting human hepatocellular carcinoma in athymic (nude) mice. Clin Sci 1983; 64: 643-8.","journal-title":"Clin Sci"},{"key":"ref_5","first-page":"349","article-title":"Monoclonal antibodies in a solid phase radiometric assay for HBsAg","volume":"38","author":"Goodall, A.H.; Miescher, G.C.; Meek, F.M.; Janossy, G.; Thomas, H.C.","year":"1981","unstructured":"Goodall AH, Miescher GC, Meek FM, Janossy G, Thomas HC. Monoclonal antibodies in a solid phase radiometric assay for HBsAg. Med Lab Sci 1981; 38: 349-54.","journal-title":"Med Lab Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0022-1759(82)90042-4","article-title":"A rapid one-step radiometric assay for hepatitis B surface antigen utilising monoclonal antibodies","volume":"52","author":"Goodall, A.H.; Meek, F.L.; Waters, J.A.; Miescher, G.C.; Janossy, G.; Thomas, H.C.","year":"1982","unstructured":"Goodall AH, Meek FL, Waters JA, Miescher GC, Janossy G, Thomas HC. A rapid one-step radiometric assay for hepatitis B surface antigen utilising monoclonal antibodies. J Immunol Meth 1982; 52: 167-74.","journal-title":"J Immunol Meth"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-065X.1982.tb00392.x","article-title":"The preparation and cytotoxic properties of antibody-toxin conjugates","volume":"62","author":"Thorpe, P.E.; Ross, W.C.J.","year":"1982","unstructured":"Thorpe PE, Ross WCJ. The preparation and cytotoxic properties of antibody-toxin conjugates. Immunol Rev 1982; 62: 119-58.","journal-title":"Immunol Rev"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/286533a0","article-title":"Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma","volume":"286","author":"Brechot, C.; Pourcel, C.; Louise, A.; Rain, B.; Tiollais, P.","year":"1980","unstructured":"Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature (Lond) 1980; 286: 533-5.","journal-title":"Nature (Lond)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/286531a0","article-title":"Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAG-producing human hepatocellular carcinoma cell line","volume":"286","author":"Chakraborty, P.R.; Ruiz-Opazo, N.; Shouval, D.; Shafritz, D.","year":"1980","unstructured":"Chakraborty PR, Ruiz-Opazo N, Shouval D, Shafritz D. Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAG-producing human hepatocellular carcinoma cell line. Nature (Lond) 1980; 286: 531-3.","journal-title":"Nature (Lond)"},{"issue":"128","key":"ref_10","first-page":"11","article-title":"Protection against experimental hepatoma formation in nude mice by monoclonal antibody to hepatitis B virus surface antigen","volume":"2","author":"Shouval, D.; Wands, JR, Zurawski; VR, Isselbacher; KJ, Shafritz; D.A.","year":"1982","unstructured":"Shouval D, Wands JR, Zurawski VR, Isselbacher KJ, Shafritz DA. Protection against experimental hepatoma formation in nude mice by monoclonal antibody to hepatitis B virus surface antigen. Hepatology 1982; 2: 128S-33S. 11 Shouval D, Shafritz DA, Zurawski VR, Issalbacher KJ, Wand JR. Immunotherapy in nude mice of human hepatoma using monoclonal antibodies against HBV. Nature 1982; 298: 567-9.","journal-title":"Hepatology; Immunotherapy in nude mice of human hepatoma using monoclonal antibodies against HBV"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/249627a0","article-title":"Mechanisms of action of the toxic lectins abrin and ricin","volume":"249","author":"Olsnes, S.; Refsnes, K.; Pihl, A.","year":"1974","unstructured":"Olsnes S, Refsnes K, Pihl A. Mechanisms of action of the toxic lectins abrin and ricin. Nature 1974; 249: 627-31.","journal-title":"Nature"},{"key":"ref_12","first-page":"765","article-title":"Detection of HBV-DNA in liver and serum: a direct appraisal of the chronic carrier state","volume":"2","author":"Brechot, C.; Hadchovel, M.; Scotto, J.; Tiollais, P.","year":"1981","unstructured":"Brechot C, Hadchovel M, Scotto J, Tiollais P. Detection of HBV-DNA in liver and serum: a direct appraisal of the chronic carrier state. Lancet 1981; 2: 765-7.","journal-title":"Lancet"},{"key":"ref_13","article-title":"An analysis of the molecular state of HBV-DNA in the liver and serum of patients with chronic hepatitis and PLC and the effect of therapy with ARA-A","volume-title":"Gut","author":"Fowler, M.J.F.; Monjardino, J.; Weller, I.V.D.; Lok, A.S.F.; Thomas, H.C.","year":"1984","unstructured":"Fowler MJF, Monjardino J, Weller IVD, Lok ASF, Thomas HC. An analysis of the molecular state of HBV-DNA in the liver and serum of patients with chronic hepatitis and PLC and the effect of therapy with ARA-A. Gut 1984. (In press)."},{"key":"ref_14","first-page":"116","article-title":"Immunological mechanisms in chronic HBV infection","volume":"2","author":"Thomas, H.C.; Montano, L.; Goodall, A.; deKoning R; Oladapo, J.; Wiedmann, K.H.","year":"1982","unstructured":"Thomas HC, Montano L, Goodall A, deKoning R, Oladapo J, Wiedmann KH. Immunological mechanisms in chronic HBV infection. Hepatology 1982; 2: 116S-21S.","journal-title":"Hepatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(76)91792-X","article-title":"Host responses to hepatitis B infection in patients with primary hepatic carcinoma and their families; a casecontrol study in Senegal, West Africa","volume":"2","author":"Larouze, B.; London, W.T.; Saimont, G.","year":"1976","unstructured":"Larouze B, London WT, Saimont G et al. Host responses to hepatitis B infection in patients with primary hepatic carcinoma and their families; a casecontrol study in Senegal, West Africa. Lancet 1976; 2: 534-8.","journal-title":"Lancet"},{"key":"ref_16","first-page":"1","article-title":"Thung SN. The relationship of hepatocellular carcinomas to infection with hepatitis B and related viruses in man and animals","volume":"2","author":"Popper, H.; Gerber, M.A.","year":"1982","unstructured":"Popper H, Gerber MA, Thung SN. The relationship of hepatocellular carcinomas to infection with hepatitis B and related viruses in man and animals. Hepatology 1982; 2: 1S-9S.","journal-title":"Hepatology"},{"key":"ref_17","article-title":"Hepatitis B virus and host cell membrane antigens on a primary hepatocellular carcinoma cell line","author":"de Koning RW; A, Goodall; Z, Varghese; HC, Thomas","year":"1984","unstructured":"de Koning RW, Goodall A, Varghese Z, Thomas HC. Hepatitis B virus and host cell membrane antigens on a primary hepatocellular carcinoma cell line. Liver 1984 (In press).","journal-title":"Liver"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.6.619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:26:21Z","timestamp":1765610781000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.6.619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1984,6,1]]},"published-print":{"date-parts":[[1984,6]]}},"alternative-id":["10.1136\/gut.25.6.619"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.6.619","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,6]]}}}