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In the 51 Cr window right colon was localised and intracolonic propulsion was studied; and in the 99m Tc window gastric emptying and colon filling of the meal marker was quantified. A propulsive gastrocolic reflex was evidenced in five of the seven patients with functional diarrhoea but in none of the normal subjects. Unabsorbed residues of the meal are propelled rapidly in the ileocaecal region. Small intestinal transit of the meal marker was twice as rapid in patients with functional diarrhoea as in normal subjects.<\/jats:p>","DOI":"10.1136\/gut.25.7.728","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"728-731","source":"Crossref","is-referenced-by-count":58,"title":["Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique."],"prefix":"10.1136","volume":"25","author":[{"given":"R","family":"Jian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Najean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,7,1]]},"reference":[{"key":"ref_1","first-page":"171","article-title":"Etude du temps de transit intestinal par la courbe de dilution du C135Cr. 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Gastroenterology 1962; 42","author":"Emonts, P.; Vidon, N.; Bernier, J.J.; Rambaud, J.C.","unstructured":"Emonts P, Vidon N, Bernier JJ, Rambaud JC. Etude sur 24 heures des flux liquidiens intestinaux chez I'homme normal par la technique de la perfusion lente d'un marqueur non absorbable. Gastroenterol Clin Biol 1979; 3:139-46 5 Horowitz L, Farrar JT. Intraluminal small intestinal pressures in normal patients and in patients with functional gastrointestinal disorders. Gastroenterology 1962; 42: 455-64."},{"key":"ref_5","first-page":"546","article-title":"Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements","volume":"85","year":"1975","unstructured":"Bond JH, Levitt MD. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med 1975; 85: 546-55.","journal-title":"J Lab Clin Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/gut.22.10.836","article-title":"Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with irritable bowel syndrome","volume":"22","author":"NW, Corbett C.L.Thomas S.Read; N, Hobson; I, Bergman; CD, Holdsworth","year":"1981","unstructured":"Corbett CL. Thomas S. Read NW, Hobson N, Bergman I, Holdsworth CD. Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with irritable bowel syndrome. Gut 1981; 22: 836-40.","journal-title":"Gut"},{"key":"ref_7","first-page":"1276","article-title":"Read NW, Miles CA, Fisher D et al. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role","volume-title":"the pathogenesis of diarrhea. Gastroenterology 1980; 79","unstructured":"Read NW, Miles CA, Fisher D et al. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology 1980; 79: 1276-82."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.11.2.91","article-title":"Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity","volume":"11","author":"Holdstock, D.J.; Misiewicz, J.J.; Smith, T.; Rowlands, E.N.","year":"1970","unstructured":"Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EN. Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. 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Gastroenterol Clin Biol 1979; 3: 755-62.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF01393765","article-title":"Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study","volume":"27","author":"Jian, R.; Vigneron, N.; Najean, Y.; Bernier, J.J.","year":"1982","unstructured":"Jian R, Vigneron N, Najean Y, Bernier JJ. Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study. Dig Dis Sci 1982; 27: 705-11.","journal-title":"Dig Dis Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0016-5085(78)90835-1","article-title":"Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity","volume":"75","author":"Snape, W.J.; Matarazzo, S.A.; Cohen, S.","year":"1978","unstructured":"Snape WJ, Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 1978; 75: 373-8.","journal-title":"Gastroenterology"},{"key":"ref_13","first-page":"704","article-title":"Inhibitory role of the distal small intestine on the gastric secretory response to","volume-title":"meals in man. Gastroenterology 1978; 74","author":"Clain JE, Go VLW, Malagelada JR","unstructured":"Clain JE, Go VLW, Malagelada JR. Inhibitory role of the distal small intestine on the gastric secretory response to meals in man. 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