{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:28:15Z","timestamp":1765603695940,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:p>A multiple linear regression analysis was carried out on 75 inpatients with gastric ulcer. In order to elucidate the effects of various factors - endoscopic and roentgenological findings, age, sex, medical history, and drugs such as antacids, anticholinergics or both - on the healing rate, these factors were compared between those with ulcer which healed within eight weeks after treatment and those which did not. In patients over 50 years of age, alcohol consumption of over 60 g per day until admission, duration of present ulcer pain for over three months, single ulcer, ulcer located in the lesser curvature and uneven elevation around the ulcer, there was significant delaying effect on ulcer healing. Drug ingestion, sex, smoking habits until admission, size, depth, and shape of ulcer, coexisting gastritis, and past and family history of ulcer disease had no significant effect on healing after eight weeks. The patients with less than two unfavourable factors (n = 46) had the best healing rate (100%) compared with those with three (n = 20) or four or more (n = 9) unfavourable factors. The healing rate of the latter two groups was 60% and 22%, respectively (p less than 0.001). A prognostic score based on these six factors represents the severity of gastric ulcer disease with regard to the healing rate in patients prescribed antacids, and\/or anticholinergic drugs.<\/jats:p>","DOI":"10.1136\/gut.25.8.881","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"881-885","source":"Crossref","is-referenced-by-count":16,"title":["Factors influencing the healing rate of gastric ulcer in hospitalised subjects."],"prefix":"10.1136","volume":"25","author":[{"given":"M","family":"Okada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Fuchigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Omae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/gut.23.7.621","article-title":"Gastric ulcer healing with tripotassium dicitrato bismuthate and subsequent relapse","volume":"23","author":"Sutton, DR","year":"1982","unstructured":"Sutton DR. Gastric ulcer healing with tripotassium dicitrato bismuthate and subsequent relapse. Gut 1982; 23: 621-4.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/gut.20.8.730","article-title":"Double-blind controlled trial of cimetidine in the healing of gastric ulcer","volume":"20","author":"Ciclitira, P.J.; Machell, R.J.; Farthing, M.J.G.; Dick, A.P.; Hunter, J.O.","year":"1979","unstructured":"Ciclitira PJ, Machell RJ, Farthing MJG, Dick AP, Hunter JO. Double-blind controlled trial of cimetidine in the healing of gastric ulcer. Gut 1979; 20: 730-4.","journal-title":"Gut"},{"key":"ref_3","first-page":"420","article-title":"Doubleblind trial comparing cimetidine with carbenozolone in the treatment of benign gastric ulcer","volume":"18","author":"Taylor, R.H.; Laidlow, J.M.; Chapman, R.G.","year":"1977","unstructured":"Taylor RH, Laidlow JM, Chapman RG et al. 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Statistical package for the social sciences","author":"Nie, N.N.; Hull, C.H.; Jenkins, J.G.; Steinbrenner, K.","year":"1975","unstructured":"Nie NN, Hull CH, Jenkins JG, Steinbrenner K. Dent DH. Statistical package for the social sciences. New York: McGraw-Hill, 1975."},{"key":"ref_9","first-page":"150","article-title":"Studies on factors affecting healing of gastric ulcer","volume":"66","author":"Nakajima, T.","year":"1976","unstructured":"Nakajima T. Studies on factors affecting healing of gastric ulcer. Am J Gastroenterol 1976; 66: 150-4.","journal-title":"Am J Gastroenterol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/00365528009181441","article-title":"The healing rate of chronic gastric ulcer in patients admitted to hospital","volume":"15","author":"Piper, D.W.; Hunt, J.; Heap, T.R.","year":"1980","unstructured":"Piper DW, Hunt J, Heap TR. The healing rate of chronic gastric ulcer in patients admitted to hospital. Scand J Gastroenterol 1980; 15: 113-7.","journal-title":"Scand J Gastroenterol"},{"key":"ref_11","first-page":"20","article-title":"The time of healing of gastric ulcers: implications","volume-title":"as to therapy. Gastroenterology 1952","volume":"20","author":"Steigman, F.; Schulman, B.","unstructured":"Steigman F, Schulman B. The time of healing of gastric ulcers: implications as to therapy. Gastroenterology 1952; 20: 20-6."},{"key":"ref_12","article-title":"Perspective and prognosis in peptic ulcer","volume":"1","author":"Bockus, H.L.","unstructured":"Bockus HL. Perspective and prognosis in peptic ulcer. In: Bockus HL, ed. Gastroenterology vol 1."},{"key":"ref_13","first-page":"938","author":"Philadelphia","year":"1974","unstructured":"Philadelphia, London, Toronto: W B Saunders, 1974: 938-48."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01072230","article-title":"Factors influencing the healing rate of chronic gastric ulcer","volume":"18","author":"Hermann, R.P.; Piper, D.W.","year":"1973","unstructured":"Hermann RP, Piper DW. Factors influencing the healing rate of chronic gastric ulcer. Am J Dig Dis 1973; 18: 1-6.","journal-title":"Am J Dig Dis"},{"key":"ref_15","first-page":"635","article-title":"The veterans administration cooperative study on gastric ulcer","volume-title":"Resume and comment. Gastroenterology 1971; 61","author":"Grossman, M.I.","unstructured":"Grossman MI. The veterans administration cooperative study on gastric ulcer. Resume and comment. Gastroenterology 1971; 61: 635-8."},{"key":"ref_16","first-page":"435","article-title":"The rate of healing of gastric ulcers","volume":"8","author":"Pollard, H.M.; Bachrach, W.H.; Block, M.","year":"1947","unstructured":"Pollard HM, Bachrach WH, Block M. The rate of healing of gastric ulcers. Gastroenterology 1947; 8: 435-7.","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0016-5085(81)80012-1","article-title":"Predictors of duodenal ulcer healing and relapse","volume":"81","author":"Sonnenberg, A.; Muller-Lissner, S.A.; Vogel, E.","year":"1981","unstructured":"Sonnenberg A, Muller-Lissner SA, Vogel E et al. Predictors of duodenal ulcer healing and relapse. Gastroenterology 1981; 81: 1061-7.","journal-title":"Gastroenterology"},{"key":"ref_18","article-title":"Handbook of aging and the social sciences","author":"Binstock, R.H.; Shanas, E.","year":"1976","unstructured":"Binstock RH, Shanas E. Handbook of aging and the social sciences. New York: Van Nostrand Reinhold Company, 1976."},{"key":"ref_19","article-title":"Textbook of geriatric medicine and gerontology","author":"Brocklehurst, J.G.","year":"1973","unstructured":"Brocklehurst JG. Textbook of geriatric medicine and gerontology. Edinburgh, London: Churchill Livingstone, 1973."},{"key":"ref_20","article-title":"Clinical aspects of aging","author":"Reichel, W.","year":"1978","unstructured":"Reichel W. Clinical aspects of aging. Baltimore: Williams and Wilkins, 1978."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3109\/00365528209181085","article-title":"Environmental factors and chronic gastric ulcer","volume":"17","author":"Piper, D.W.; McIntosh, J.H.; Greig, M.; Shy, C.M.","year":"1982","unstructured":"Piper DW, McIntosh JH, Greig M, Shy CM. Environmental factors and chronic gastric ulcer. Scand J Gastroenterol 1982; 17: 721-9.","journal-title":"Scand J Gastroenterol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","article-title":"Cytoprotection by prostaglandins","volume":"77","author":"Robert, A.","year":"1979","unstructured":"Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761-7.","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(58)91083-3","article-title":"Effect of smoking on the production and maintenance of gastric and duodenal ulcers","volume":"1","author":"Doll, R.; Jones, F.A.; Pygott, F.","year":"1958","unstructured":"Doll R, Jones FA, Pygott F. Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet 1958; 1: 657-62.","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gut.22.2.97","article-title":"Factors affecting the healing rate of duodenal and pyloric ulcers with low-dose antacid treatment","volume":"22","author":"Massarrat, S.; Eisenmann, A.","year":"1981","unstructured":"Massarrat S, Eisenmann A. Factors affecting the healing rate of duodenal and pyloric ulcers with low-dose antacid treatment. Gut 1981; 22: 97-102.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.8.881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:26:00Z","timestamp":1765603560000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.8.881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1984,8,1]]},"published-print":{"date-parts":[[1984,8]]}},"alternative-id":["10.1136\/gut.25.8.881"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.8.881","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,8]]}}}