{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T18:36:22Z","timestamp":1767119782970,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>The effectiveness of two commonly available liquid diets was assessed in 40 severely malnourished black African patients. All patients were shown to have normal xylose absorption. The diets were given according to the manufacturer's recommendations. One diet was lactose containing (LC diet) (150 g\/d) and high protein (112 g\/d), the other normal protein and lactose free (LF diet) (protein 67 g\/d), total energy content being similar. Patients were randomly divided into two equal groups and allocated (blind) to one of the diets. Tolerance and nitrogen balance were assessed over two three day periods on half and then full strength formulations. Severe intolerant symptoms were observed in 50% of patients on half strength and 94% of patients on full strength lactose containing diet with evidence of malabsorption of fluid, nitrogen, and fat. Despite high stool nitrogen losses (3.75 +\/- 1.04 g\/d), however, positive nitrogen balance was achieved in most patients receiving the full strength LC formulation. On the other hand, the full strength LF diet was generally well tolerated and was associated with significantly lower faecal losses and positive nitrogen balance. The results indicate that high density lactose containing liquid formulae are poorly tolerated by severely malnourished black African patients, while lactose free formulae containing approximately 10 g nitrogen\/d are well tolerated and result in positive nitrogen balance.<\/jats:p>","DOI":"10.1136\/gut.25.9.942","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"942-947","source":"Crossref","is-referenced-by-count":19,"title":["Nutritional support of malnourished lactose intolerant African patients."],"prefix":"10.1136","volume":"25","author":[{"given":"S J","family":"O'Keefe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"ref_1","first-page":"778","article-title":"Primary lactose intolerance in Zulu adults","volume":"63","author":"O'Keefe, S.J.D.; Adam, J.K.","year":"1983","unstructured":"O'Keefe SJD, Adam JK. Primary lactose intolerance in Zulu adults. S Afr Med J 1983; 63: 778-80.","journal-title":"S Afr Med J"},{"key":"ref_2","article-title":"Human protein requirements: inter-relationships between energy intake and nitrogen balance in young men consuming the 1973 FAO\/WHO safe level of eggs protein with patients is consistent with this hypothesis. The added non-essential aminoacids","author":"Garza, C.; Scrimshaw, N.S.; Young, V.R.","year":"1978","unstructured":"Garza C, Scrimshaw NS, Young VR. Human protein requirements: inter-relationships between energy intake and nitrogen balance in young men consuming the 1973 FAO\/WHO safe level of eggs protein with patients is consistent with this hypothesis. The added non-essential aminoacids. 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Pediatr Res 1972; 6: 329.","journal-title":"Pediatr Res"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.9.942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:41:23Z","timestamp":1765075283000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.9.942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1984,9,1]]},"published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1136\/gut.25.9.942"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.9.942","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}