{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:10:30Z","timestamp":1765649430983,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>In a single blind multicentre study, the efficacy and safety of ranitidine was compared with cimetidine in patients with gastric ulcer confirmed by endoscopy. Patients were randomly allocated to receive either 150 mg ranitidine twice daily, or 200 mg cimetidine three times a day and 400 mg at night for four weeks; patients with unhealed ulcers continued the same treatment for a further two weeks. Out of 260 patients, 197 were analysed. Of the ranitidine treated patients, 66% were healed after four weeks and 78% after six weeks and of the cimetidine treated patients 62% were healed after four weeks and 87% after six weeks. These differences are not significant. These results confirmed that ranitidine is as effective as cimetidine in the acute treatment of gastric ulcer.<\/jats:p>","DOI":"10.1136\/gut.25.9.999","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"999-1002","source":"Crossref","is-referenced-by-count":12,"title":["Single blind comparative study of ranitidine and cimetidine in patients with gastric ulcer. The Belgian Peptic Ulcer Study Group."],"prefix":"10.1136","volume":"25","member":"239","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"ref_1","first-page":"464","article-title":"Ranitidine (AH 19065): a new potent selective histamine H2-receptor antagonist?","volume":"66","author":"Bradshaw, J.; Brittain, R.T.; Clitherow, J.W.","year":"1979","unstructured":"Bradshaw J, Brittain RT, Clitherow JW et al. Ranitidine (AH 19065): a new potent selective histamine H2-receptor antagonist? Br J Pharmacol 1979; 66: 464.","journal-title":"Br J Pharmacol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(79)90728-1","article-title":"Gastric inhibitory action of H2-antagonists, ranitidine and cimetidine","volume":"1","author":"Domschke, W.; Lux, G.; Domschke, S.","year":"1979","unstructured":"Domschke W, Lux G, Domschke S. Gastric inhibitory action of H2-antagonists, ranitidine and cimetidine. Lancet 1979; 1: 320.","journal-title":"Lancet"},{"key":"ref_3","first-page":"690","article-title":"Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine","volume":"1","author":"Peden, N.; Saunders, J.; Wormsley, K.","year":"1979","unstructured":"Peden N, Saunders J, Wormsley K. Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. Lancet 1979; 1: 690-2.","journal-title":"Lancet"},{"key":"ref_4","first-page":"181","article-title":"Comparison of rantidine and cimetidine in the inhibition of histamine sham-feeding and meal-induced gastric secretion in duodenal ulcer patients","volume-title":"Gut","volume":"21","author":"Konturek, S.J.; Obtulowicz, W.; Kwiecien, N.","year":"1980","unstructured":"Konturek SJ, Obtulowicz W, Kwiecien N et al. Comparison of rantidine and cimetidine in the inhibition of histamine sham-feeding and meal-induced gastric secretion in duodenal ulcer patients. Gut 1980; 21: 181-6."},{"issue":"16","key":"ref_5","first-page":"19","article-title":"Investigation on the penetration of rantidine into the cerebrospinal fluid and a comparison of the effects of ranitidine and cimetidine on male sex hormones","volume":"1981","author":"Walt, R.P.; LaBrooy, S.J.; Avgerinos, A.; Oehr, T.; Riley, A.; Misiewicz, J.J.","unstructured":"Walt RP, LaBrooy SJ, Avgerinos A, Oehr T, Riley A, Misiewicz JJ. Investigation on the penetration of rantidine into the cerebrospinal fluid and a comparison of the effects of ranitidine and cimetidine on male sex hormones. Scand J Gastroenterol 1981; 16 suppl 69: 19-25.","journal-title":"Scand J Gastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/00498258209052450","article-title":"Interaction of ranitidine with liver microsomes","volume":"12","author":"Rendic, S.; Alebic-Kolbah, T.; Kajfez, F.; Ruf, H.-H.","year":"1982","unstructured":"Rendic S, Alebic-Kolbah T, Kajfez F, Ruf H-H. Interaction of ranitidine with liver microsomes. Xenobiotica 1982; 12: 9-17.","journal-title":"Xenobiotica"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1145\/321765.321778","article-title":"An asymptotically random Tausworthe sequence","volume":"20","author":"Tootill, J.P.R.; Robinson, W.D.; Eagle, D.J.","year":"1973","unstructured":"Tootill JPR, Robinson WD, Eagle DJ. An asymptotically random Tausworthe sequence. J Assoc Comput Machinery 1973; 20: 469-81.","journal-title":"J Assoc Comput Machinery"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto, R.; Pike, M.C.; Armitage, P.","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977; 35: 1-39.","journal-title":"II. Analysis and examples. Br J Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/bmj.2.6090.795","article-title":"Cimetidine in patients with gastric ulcer. A multicentre controlled trial","volume":"2","author":"Frost, F.; Rahbek, I.; Rune, S.J.","year":"1977","unstructured":"Frost F, Rahbek I, Rune SJ et al. Cimetidine in patients with gastric ulcer. A multicentre controlled trial. Br Med J 1977; 2: 795-9.","journal-title":"Br Med J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0016-5085(78)90773-4","article-title":"Cimetidine and placebo in the treatment of benign gastric ulcer. A multicenter double blind study","volume":"74","author":"Dyck, W.P.; Belsito, A.; Fleshler, T.R.; Lieberman, P.B.; Dickinson, M.D.; Wood, J.M.","year":"1978","unstructured":"Dyck WP, Belsito A, Fleshler TR, Lieberman PB, Dickinson MD, Wood JM. Cimetidine and placebo in the treatment of benign gastric ulcer. A multicenter double blind study. Gastroenterology 1978; 74: 410-5.","journal-title":"Gastroenterology"},{"key":"ref_11","first-page":"30","article-title":"Clinical evaulation of H2-receptor antagonists in the therapy of gastric ulcer in Japan","author":"Takemoto, T.; Okita, K.; Namiki, M.; Ishikawa, M.; Oshiba, S.","year":"1982","unstructured":"Takemoto T, Okita K, Namiki M, Ishikawa M, Oshiba S. Clinical evaulation of H2-receptor antagonists in the therapy of gastric ulcer in Japan. In: Riley AJ, Salmon PR, eds. Ranitidine. Proceedings of an International Symposium held in the context of the Seventh World Congress on Gastroenterology, Stockholm, 17th June 1982. Amsterdam: Excerpta Medica, 1982: 30-44.","journal-title":"Proceedings of an International Symposium held in the context of the Seventh World Congress on Gastroenterology, Stockholm, 17th; Excerpta Medica"},{"key":"ref_12","first-page":"155","article-title":"Ranitidine in the treatment of gastric ulceration","volume":"61","author":"Wright, J.P.; Marks, I.N.; Mee, L.S.","year":"1982","unstructured":"Wright JP, Marks IN, Mee LS et al. Ranitidine in the treatment of gastric ulceration. S Afr Med J 1982; 61: 155-8.","journal-title":"S Afr Med J"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.25.9.999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:07:41Z","timestamp":1765649261000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.25.9.999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1984,9,1]]},"published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1136\/gut.25.9.999"],"URL":"https:\/\/doi.org\/10.1136\/gut.25.9.999","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}