{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:15:28Z","timestamp":1765649728804,"version":"3.48.0"},"reference-count":7,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p>One hundred and four children were initially assessed by clinical, radiological, and endoscopic criteria as chronic inflammatory bowel disease. All were assessed independently using precise histological diagnostic criteria. Fifty eight patients were diagnosed as Crohn's disease, 25 as ulcerative colitis, 15 remained provisionally categorised as indeterminate colitis and six proved to be normal. Diagnostic granulomas were found in 36% of endoscopic biopsies from the 58 children with Crohn's disease. This appears to be an underestimate as only four of 14 children with granulomatous Crohn's disease operated on had granulomas on endoscopic biopsy. This study shows that there is a spectrum of histological appearances in endoscopic biopsies in chronic inflammatory bowel disease in childhood ranging from definite Crohn's disease to definite ulcerative colitis with indeterminate features in between. Accurate histological diagnosis of chronic inflammatory bowel disease is dependent upon either multiple endoscopic biopsies or assessment of a surgically resected specimen.<\/jats:p>","DOI":"10.1136\/gut.26.1.55","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"55-59","source":"Crossref","is-referenced-by-count":89,"title":["Histological diagnosis of chronic inflammatory bowel disease in childhood."],"prefix":"10.1136","volume":"26","author":[{"given":"S K","family":"Chong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Blackshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Walker-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,1,1]]},"reference":[{"key":"ref_1","first-page":"101","article-title":"We thank CICRA (Crohn's disease in Childhood Blackshaw AJ, Walker-Smith JA. Chronic inflammatory bowel disease in childhood","volume":"284","author":"Chong, S.K.F.; Bartram, C.I.; Campbell, C.A.; Williams, C.B.","year":"1982","unstructured":"Chong SKF, Bartram CI, Campbell CA, Williams CB, We thank CICRA (Crohn's disease in Childhood Blackshaw AJ, Walker-Smith JA. Chronic inflammatory bowel disease in childhood. Br Med J 1982; 284: 101-3.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jcp.31.6.567","article-title":"Overlap in the spectrum of non-specific inflammatory bowel disease - 'colitis indeterminate'","volume":"31","author":"Price, A.B.","year":"1978","unstructured":"Price AB. Overlap in the spectrum of non-specific inflammatory bowel disease - 'colitis indeterminate'. J Clin Pathol 1978; 31: 567-77.","journal-title":"J Clin Pathol"},{"key":"ref_3","first-page":"221","article-title":"Differential diagnosis of inflammatory bowel disease","volume-title":"Radiology in inflammatory bowel disease","author":"Bartram, C.I.","year":"1983","unstructured":"Bartram CI. Differential diagnosis of inflammatory bowel disease. In: Bartram CI ed. Radiology in inflammatory bowel disease. New York: Marcel Dekker, 1983: 221-58."},{"key":"ref_4","first-page":"86","article-title":"Colonoscopy","volume-title":"gastrointestinal endoscopy","author":"Cotton, P.B.; Williams, C.B.","year":"1980","unstructured":"Cotton PB, Williams CB. Colonoscopy. In: Cotton PB, Williams CB eds. Practical gastrointestinal endoscopy. Oxford: Blackwell Scientifiic Publications, 1980: 86-127."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0016-5107(75)73675-1","article-title":"The value of colonoscopy in diagnosis of Crohn's disease","volume":"22","author":"Geboes, K.; Vantrappen, G.","year":"1975","unstructured":"Geboes K, Vantrappen G. The value of colonoscopy in diagnosis of Crohn's disease. Gastrointest Endosc 1975; 22: 18-23.","journal-title":"Gastrointest Endosc"},{"key":"ref_6","first-page":"27","article-title":"Chronic inflammatory bowel disease in the young","volume":"8","author":"Chong, S.K.F.; Walker-Smith, J.A.","year":"1982","unstructured":"Chong SKF, Walker-Smith JA. Chronic inflammatory bowel disease in the young. Compr Ther 1982; 8: 27-34.","journal-title":"Compr Ther"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0016-5085(75)80064-3","article-title":"Problems in the differentiation of ulcerative colitis and Crohn's disease of the colon: the need for repeated diagnostic evaluation","volume":"68","author":"Kirsner, J.B.","year":"1974","unstructured":"Kirsner JB. Problems in the differentiation of ulcerative colitis and Crohn's disease of the colon: the need for repeated diagnostic evaluation. Gastroenterology 1974; 68: 187-91.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.1.55","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:13:01Z","timestamp":1765649581000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.1.55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1985,1,1]]},"published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1136\/gut.26.1.55"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.1.55","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}