{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:00:58Z","timestamp":1763751658431,"version":"3.45.0"},"reference-count":4,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:p>Splenic function was assessed using 'pitted' erythrocyte counts in 61 first degree relatives of patients with coeliac disease. 'Pitted' erythrocyte counts were normal in 12 parents, but were raised in 20% of 49 siblings and\/or children of coeliac patients. First degree relatives had higher 'pitted' erythrocyte counts than normal controls (p = 0.002). The counts were lower in coeliac relatives than in age matched coeliacs (p = 0.0001), but no difference was present between the relatives and coeliac patients whose small bowel mucosa was morphologically normal. Considerable interfamily variation was found in 'pitted' erythrocyte counts, both in the coeliac patients and first degree relatives, and the pattern tended to 'run true' within families. The genetic factor influencing splenic function in coeliac disease is not HLA-linked but seems to be associated with a second, probably recessive, gene influencing the inheritance of coeliac disease.<\/jats:p>","DOI":"10.1136\/gut.26.10.1004","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1004-1007","source":"Crossref","is-referenced-by-count":6,"title":["Genetic influences on splenic function in coeliac disease."],"prefix":"10.1136","volume":"26","author":[{"given":"J G","family":"O'Grady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C F","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,10,1]]},"reference":[{"key":"ref_1","first-page":"1326","article-title":"Hyposplenism in glutensensitive enteropathy: Natural history, incidence and relationship to diet and small bowel morphology","volume":"87","author":"O'Grady, J.G.; Stevens, F.M.; Harding, B.; O'Gorman, T.A.; McNicholl, B.; McCarthy, C.F.","year":"1984","unstructured":"O'Grady JG, Stevens FM, Harding B, O'Gorman TA, McNicholl B, McCarthy CF. Hyposplenism in glutensensitive enteropathy: Natural history, incidence and relationship to diet and small bowel morphology. Gastroenterology 1984; 87: 1326-31.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ajmg.1320120110","article-title":"A maximum likelihood test their coeliac parent. This could reflect a situation of the two-locus model of coeliac disease","volume":"12","author":"Greenberg, D.A.; Lange, K.L.","year":"1982","unstructured":"Greenberg DA, Lange KL. A maximum likelihood test their coeliac parent. This could reflect a situation of the two-locus model of coeliac disease. Am J Med where the children are homozygous for the Gm Genet 1982; 12: 75-82.","journal-title":"Am J Med where the; children are homozygous for the Gm Genet"},{"key":"ref_3","first-page":"952","article-title":"Immunoglobulin allotype markers in glutensensitive enteropathy","volume":"1","author":"Kagnoff, M.F.; Weiss, J.B.; Brown, R.J.; Lee, T.; Schanfield, M.S.","year":"1983","unstructured":"Kagnoff MF, Weiss JB, Brown RJ, Lee T, Schanfield MS. Immunoglobulin allotype markers in glutensensitive enteropathy. Lancet 1983; 1: 952-3.","journal-title":"Lancet"},{"key":"ref_4","article-title":"Simple method of assessing splenic function in adult coeliac disease","author":"Corazza, G.R.; Bullen, A.W.; Hall, R.; Brown, R.C.; Baxter, P.; Losowsky, M.S.","year":"1981","unstructured":"Corazza GR, Bullen AW, Hall R, Brown RC, Baxter P, Losowsky MS. Simple method of assessing splenic function in adult coeliac disease. Clin Sci 1981; 60: predisposition coupled with an as yet unidentified 109-13.","journal-title":"Clin Sci; 60: predisposition coupled with an as yet unidentified 109-13"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.10.1004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:54:52Z","timestamp":1763751292000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.10.1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":4,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1985,10,1]]},"published-print":{"date-parts":[[1985,10]]}},"alternative-id":["10.1136\/gut.26.10.1004"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.10.1004","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}