{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:26:43Z","timestamp":1782419203433,"version":"3.54.5"},"reference-count":18,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:p>Motilin, pancreatic polypeptide and gastrin blood concentrations in response to drinking water have been studied in 40 patients with functional bowel disease and compared with results in two groups of healthy control subjects. Patients with slow transit constipation and idiopathic megacolon showed impaired motilin release. Pancreatic polypeptide release was reduced in patients with slow transit constipation, but increased in those with functional diarrhoea. Gastrin release was impaired in all groups complaining of chronic constipation. Circulating motilin, pancreatic polypeptide and gastrin concentrations appear to bear some relationship to intestinal transit time in patients with functional bowel disorders.<\/jats:p>","DOI":"10.1136\/gut.26.10.1059","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1059-1064","source":"Crossref","is-referenced-by-count":67,"title":["Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders."],"prefix":"10.1136","volume":"26","author":[{"given":"D M","family":"Preston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N D","family":"Christofides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Lennard-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/BF01962823","article-title":"Modlin IM. Release of gastrointestinal hormones following an oral water load","volume":"35","author":"Christofides, N.D.; Sarson, D.L.; Albuquerque, R.H.; Adrian, T.E.; Ghatei, M.A.","year":"1979","unstructured":"Christofides ND, Sarson DL, Albuquerque RH, Adrian TE, Ghatei MA, Modlin IM. Release of gastrointestinal hormones following an oral water load. Experientia 1979; 35: 1521-2.","journal-title":"Experientia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01893094","article-title":"Towards a radiologic definition of idiopathic megacolon","volume":"10","author":"Preston, D.M.; Lennard-Jones, J.E.; Thomas, B.M.","year":"1985","unstructured":"Preston DM, Lennard-Jones JE, Thomas BM. Towards a radiologic definition of idiopathic megacolon. Gastrointest Radiol 1985; 10: 167-9.","journal-title":"Gastrointest Radiol"},{"issue":"10","key":"ref_3","first-page":"842","article-title":"A new method for studying gut transit times using radioopaque markers","volume":"1969","author":"Hinton, J.M.; Lennard-Jones, J.E.; Young, A.C.","unstructured":"Hinton JM, Lennard-Jones JE, Young AC. A new method for studying gut transit times using radioopaque markers. Gut 1969; 10: 842-7.","journal-title":"Gut"},{"key":"ref_4","article-title":"RG (ed). Radioimmunoassay of gut regulatory peptides","author":"Bloom, SR, Long","year":"1982","unstructured":"Bloom SR, Long RG (ed). Radioimmunoassay of gut regulatory peptides. London: W B Saunders Co, 1982."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000198566","article-title":"Gut hormone response in the irritable bowel syndrome","volume":"21","author":"Besterman, H.S.; Sarson, D.L.; Rambaud, J.C.; Stewart, J.S.; Guerin, S.; Bloom, SR","year":"1981","unstructured":"Besterman HS, Sarson DL, Rambaud JC, Stewart JS, Guerin S, Bloom SR. Gut hormone response in the irritable bowel syndrome. Digestion 1981; 21: 219-24.","journal-title":"Digestion"},{"key":"ref_6","first-page":"280","article-title":"Effect of motilin on gastrointestinal tract motility","author":"Itoh, Z.","year":"1981","unstructured":"Itoh Z. Effect of motilin on gastrointestinal tract motility. In: Bloom SR, ed. Gut hormones. London: Churchill Livingstone, 1981: 280-9."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/bmj.285.6353.1453","article-title":"Decreased plasma motilin concentrations in pregnancy","volume":"285","author":"Christofides, N.D.; Ghatei, M.A.; Bloom, SR, Borberg; C, Gillmer; M.D.G.","year":"1982","unstructured":"Christofides ND, Ghatei MA, Bloom SR, Borberg C, Gillmer MDG. Decreased plasma motilin concentrations in pregnancy. Br Med J 1982; 285: 1453-4.","journal-title":"Br Med J"},{"key":"ref_8","first-page":"1243","volume-title":"Motilin and human colonic activity. [Abstract] Gastroenterology 1980","volume":"78","author":"Rennie, J.A.; Christofides, N.D.; Mitchenere, P.; Johnson, A.G.; Bloom, SR","unstructured":"Rennie JA, Christofides ND, Mitchenere P, Johnson AG, Bloom SR. Motilin and human colonic activity. [Abstract] Gastroenterology 1980; 78: A1243."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(78)92994-X","article-title":"Gut hormone profile in coeliac disease","volume":"1","author":"Besterman, H.S.; Bloom, SR, Sarson; D.L.","year":"1978","unstructured":"Besterman HS, Bloom SR, Sarson DL et al. Gut hormone profile in coeliac disease. Lancet 1978; 1: 785-8.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1136\/bmj.2.6200.1252","article-title":"Gut hormones in tropical malabsorption","volume":"2","author":"Besterman, H.S.; Cook, G.C.; Sarson, D.L.","year":"1979","unstructured":"Besterman HS, Cook GC, Sarson DL et al. Gut hormones in tropical malabsorption. Br Med J 1979; 2: 1252-5.","journal-title":"Br Med J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/gut.24.7.665","article-title":"Gut hormones in acute diarrhoea","volume":"24","author":"Besterman, H.S.; Christofides, N.D.; Welsby, P.D.; Adrian, T.E.; Sarson, D.L.; Bloom, SR","year":"1983","unstructured":"Besterman HS, Christofides ND, Welsby PD, Adrian TE, Sarson DL, Bloom SR. Gut hormones in acute diarrhoea. Gut 1983; 24: 665-71.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/gut.23.10.854","article-title":"Gut hormones release after intestinal resection","volume":"23","author":"Besterman, H.S.; Adrian, T.E.; Mallinson, C.N.","year":"1982","unstructured":"Besterman HS, Adrian TE, Mallinson CN et al. Gut hormones release after intestinal resection. Gut 1982; 23: 854-61.","journal-title":"Gut"},{"key":"ref_13","first-page":"456","article-title":"Effect of motilin on the gastric emptying of glucose","volume-title":"and fat in humans. Gastroenterology 1981; 80","author":"Christofides, N.D.; Long, R.G.; Fitzpatrick, M.L.; McGregor, G.P.; Bloom, SR","unstructured":"Christofides ND, Long RG, Fitzpatrick ML, McGregor GP, Bloom SR. Effect of motilin on the gastric emptying of glucose and fat in humans. Gastroenterology 1981; 80: 456-60."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF01489315","article-title":"Motilin and the interdigestive migrating motor complex in man","volume":"24","author":"Vantrappen, G.; Janssens, J.; Peeters, T.L.; Bloom, SR, Christofides; ND, Hellemans; J.","year":"1979","unstructured":"Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides ND, Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 1979; 24: 497-500.","journal-title":"Dig Dis Sci"},{"key":"ref_15","first-page":"242","article-title":"Spectrum of gastrointestinal actions of bovine PP","author":"Lin, T.M.; Chance, R.E.","year":"1978","unstructured":"Lin TM, Chance RE. Spectrum of gastrointestinal actions of bovine PP. In: Bloom SR, ed. Gut hormones. London: Churchill Livingstone, 1978: 242-6."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/00365521.1976.12097086","article-title":"-Post prandial changes in colonic motility related to serum gastrin levels","volume":"11","author":"Kirwan, W.O.; Smith, A.N.","year":"1976","unstructured":"Kirwan WO, Smith AN. -Post prandial changes in colonic motility related to serum gastrin levels. Scand J Gastroenterol 1976; 11: 145-9.","journal-title":"Scand J Gastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/gut.9.2.139","article-title":"Effect of irritant purgatives on the myenteric plexus in man and the mouse","volume":"9","author":"Smith, B.","year":"1968","unstructured":"Smith B. Effect of irritant purgatives on the myenteric plexus in man and the mouse. Gut 1968; 9: 139-43.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01391629","article-title":"Colonic inhibition of gastric secretion in man","volume":"26","author":"Jian, R.; Besterman, H.S.; Sarson, D.L.","year":"1981","unstructured":"Jian R, Besterman HS, Sarson DL et al. Colonic inhibition of gastric secretion in man. Dig Dis Sci 1981; 26: 195-201.","journal-title":"Dig Dis Sci"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.10.1059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:40:37Z","timestamp":1765006837000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.10.1059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1985,10,1]]},"published-print":{"date-parts":[[1985,10]]}},"alternative-id":["10.1136\/gut.26.10.1059"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.10.1059","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}