{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:13:09Z","timestamp":1765599189849,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:p>Thrombocytopenia in cirrhotic patients is usually attributed to splenic pooling whereas in idiopathic thrombocytopenic purpura it is related to platelet bound immunoglobulin (PA-IgG). Since primary biliary cirrhosis (PBC) is an autoimmune disorder we have undertaken a prospective study to assess the frequency and possible relationship of PA-IgG to thrombocytopenia in this condition. Sixty-two primary biliary cirrhosis patients (28 precirrhotic; 34 cirrhotic) were studied. Twenty-five patients (40%) had raised PA-IgG of whom 18 had cirrhosis. There was a significant inverse correlation between platelet count and PA-IgG (p less than 0.001) and between platelet count and spleen size (p less than 0.001). Thrombocytopenia (platelets less than 100 X 10(9)\/l) was found in nine patients (15%); all nine had raised PA-IgG and eight were cirrhotic with an enlarged spleen. Two cirrhotic patients with persistent thrombocytopenia and bleeding episodes were treated with prednisolone and showed a useful therapeutic response. These results suggest that immune mediated platelet destruction and splenic pooling of platelets may both play a part in the thrombocytopenia observed in primary biliary cirrhosis.<\/jats:p>","DOI":"10.1136\/gut.26.10.1074","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1074-1079","source":"Crossref","is-referenced-by-count":32,"title":["Platelet associated immunoglobulins in primary biliary cirrhosis: a cause of thrombocytopenia?"],"prefix":"10.1136","volume":"26","author":[{"given":"M F","family":"Bassendine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O F","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM198105073041904","article-title":"Chronic idiopathic thrombocytopenic purpura","volume":"304","author":"McMillan, R.","year":"1981","unstructured":"McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med 1981; 304: 1135-47.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1182\/blood.V55.5.730.730","article-title":"Influence of the amount of platelet bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia","volume":"55","author":"Kernoff, L.M.; Blake, K.C.H.; Shackleton, D.","year":"1980","unstructured":"Kernoff LM, Blake KCH, Shackleton D. Influence of the amount of platelet bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia. Blood, 1980; 55: 730-3.","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1182\/blood.V50.2.317.317","article-title":"Platelet associated IgG in immune thrombocytopenic purpura","volume":"50","author":"Luiken, G.A.; McMillan, R.; Lightsey, A.C.","year":"1977","unstructured":"Luiken GA, McMillan R, Lightsey AC et al. Platelet associated IgG in immune thrombocytopenic purpura. Blood 1977; 50: 317-25.","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1056\/NEJM197901183000302","article-title":"Immune thiombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 in platelets","volume":"300","author":"Cines, D.B.; Schreiber, A.D.","year":"1979","unstructured":"Cines DB, Schreiber AD. Immune thiombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 in platelets. N Engl J Med 1979; 300: 106-11.","journal-title":"N Engl J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1182\/blood.V60.4.1050.1050","article-title":"A prospective study of the usefulness of the measurement of plateletassociated IgG for the diagnosis of idiopathic thrombocytopenic purpura","volume":"60","author":"Kelton, J.G.; Powers, P.J.; Carter, C.J.","year":"1982","unstructured":"Kelton JG, Powers PJ, Carter CJ. A prospective study of the usefulness of the measurement of plateletassociated IgG for the diagnosis of idiopathic thrombocytopenic purpura. Blood 1982; 60: 1050-3.","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2141.1982.tb07285.x","article-title":"Immunemediated platelet destruction and thrombocytopenia in patients with solid tumours","author":"Schwartz, K.A.; Slichter, S.J.; Harker, L.A.","year":"1982","unstructured":"Schwartz KA, Slichter SJ, Harker LA. Immunemediated platelet destruction and thrombocytopenia in patients with solid tumours. Br J Haematol 1982; 51: of platelets in an enlarged spleen is a cause of 17-24.","journal-title":"Br J Haematol; 51: of platelets in an enlarged spleen is a cause of 17-24"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2141.1981.tb02721.x","article-title":"Platelet associated immunoglobulins in chronic liver disease","volume":"48","author":"Barison, I.G.; Knight, I.D.; Viola, L.; Boots, M.A.; Murray-Lyon, I.M.; Mitchell, T.R.","year":"1981","unstructured":"Barison IG, Knight ID, Viola L, Boots MA, Murray-Lyon IM, Mitchell TR. Platelet associated immunoglobulins in chronic liver disease. Br J Haematol 1981; 48: 347-50.","journal-title":"Br J Haematol"},{"article-title":"Tissue antibodies in primary biliary cirrhosis, active chronic may be reached by measurement of PA-IgG in hepatitis, cryptogenic cirrhosis and other liver disease conjunction with studies of platelet survival and sites and their implications. 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