{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:03:46Z","timestamp":1787162626355,"version":"build-2736575974"},"reference-count":28,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>We have studied the frequency of HLA-DR, -MT, and -MB antigens in adult patients with coeliac disease and in a group of healthy controls, evaluating the strength of the observed associations by measuring the aetiologic fractions. Among the antigens significantly associated with coeliac disease, MB2 (DQw2) showed an aetiologic fraction higher than those of DR3 and DR7. Our results suggest that MB2, as associated more frequently than other specificities with a hypothetical disease predisposing gene, may play a role in the pathogenesis of coeliac disease. The significant association of DR3 and DR7 with coeliac disease may be ascribed to linkage disequilibrium of these antigens with MB2.<\/jats:p>","DOI":"10.1136\/gut.26.11.1210","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1210-1213","source":"Crossref","is-referenced-by-count":39,"title":["DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease."],"prefix":"10.1136","volume":"26","author":[{"given":"G R","family":"Corazza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Tabacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Frisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Prati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,11,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Overview of the 1980 International Histocompatibility Workshop","author":"Terasaki, P.I.; Park, M.S.; Bernoco, D.; Opelz, G.; Mickey, M.R.","year":"1980","unstructured":"Terasaki PI, Park MS, Bernoco D, Opelz G, Mickey MR. Overview of the 1980 International Histocompatibility Workshop. In: Terasaki PI, ed. Histocompatibility testing 1980. Los Angeles: UCLA Tissue between coeliac disease and the new specificity Typing Laboratory, 1980: 1-17."},{"key":"ref_2","first-page":"138","article-title":"Association of the B-cell alloantigen MB1","volume-title":"with HLA-DRw2. Transplant Proc 1980; 12","author":"Duquesnoy, R.J.; Marrari, M.; Annen, K.","unstructured":"Duquesnoy RJ, Marrari M, Annen K. Association of the B-cell alloantigen MB1 with HLA-DRw2. Transplant Proc 1980; 12: 138-40."},{"key":"ref_3","article-title":"B-lymphocyte alloantigens associated with systemic lupus erythematosus. N Engl J As far as the antigens with a raised preventive Med 1978; 299: 515-8. DR and non-DR la allotypes are associated with susceptibility to coeliac disease","author":"Reinertsen, J.L.; Klippel, J.H.; Johnson, A.H.; Steinberg, A.D.; Decker, J.L.; Mann, D.L.","unstructured":"Reinertsen JL, Klippel JH, Johnson AH, Steinberg AD, Decker JL, Mann DL. B-lymphocyte alloantigens associated with systemic lupus erythematosus. N Engl J As far as the antigens with a raised preventive Med 1978; 299: 515-8. DR and non-DR la allotypes are associated with susceptibility to coeliac disease"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJM197910043011405","article-title":"Genetic differences between primary and secondary sicca syndrome","volume":"301","author":"Moutsopoulos, H.M.; Mann, D.L.; Johnson, A.H.; Chused, T.M.","year":"1979","unstructured":"Moutsopoulos HM, Mann DL, Johnson AH, Chused TM. Genetic differences between primary and secondary sicca syndrome. N Engl J Med 1979; 301: 761-3.","journal-title":"N Engl J Med"},{"key":"ref_5","first-page":"668","article-title":"Coeliac disease and its association with HLA markers","author":"Betuel, H.; Gebuhrer, L.; Descos, L.; Bertrand, D.J.; Freycon, F.; Lepetit, J.C.","year":"1980","unstructured":"Betuel H, Gebuhrer L, Descos L, Bertrand DJ, Freycon F, Lepetit JC. Coeliac disease and its association with HLA markers. In: Terasaki PI, ed. Histocompatibility testing 1980. Los Angeles: UCLA Tissue Typing Laboratory, 1980: 668-72."},{"key":"ref_6","first-page":"283","article-title":"Separation and typing","author":"Longo, A.; B-cell, Ferrara G.B.Human","year":"1980","unstructured":"Longo A, Ferrara GB. Human B-cell. Separation and typing. In: Terasaki PI, ed. Histocompatibility testing 1980. Los Angeles: UCLA Tissue Typing Laboratory, 1980: 283-4."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcp\/69.2.103","volume":"69","author":"Terasaki, P.I.; Bernoco, D.; Park, M.S.; Ozturk, G.; testing for HLA-A, Iwaki Y.Microdroplet; B, C.; antigens","year":"1978","unstructured":"Terasaki PI, Bernoco D, Park MS, Ozturk G, Iwaki Y. Microdroplet testing for HLA-A,B,C, and DR antigens. Am J Clin Pathol 1978; 69: 103-20.","journal-title":"Am J Clin Pathol"},{"key":"ref_8","first-page":"95","article-title":"HL-A antigens and disease. Statistical and genetical considerations","volume":"4","author":"Svejgaard, A.; Jersild, C.; Staub Nielsen, L.; Bodmer, W.F.","year":"1974","unstructured":"Svejgaard A, Jersild C, Staub Nielsen L, Bodmer WF. HL-A antigens and disease. Statistical and genetical considerations. 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Estimation of absolute risk, etiologic and preventive fraction. Tissue Antigens 1982; 19: 259-68.","journal-title":"Tissue Antigens"},{"key":"ref_11","first-page":"506","article-title":"HLA-Dw3 associated with coeliac disease","volume":"1","author":"Keuning, J.J.; Pena, A.S.; van Leeuwen, A.; van Hoff, J.P.; van Rood, J.J.","year":"1976","unstructured":"Keuning JJ, Pena AS, van Leeuwen A, van Hoff JP, van Rood JJ. HLA-Dw3 associated with coeliac disease. Lancet 1976; 1: 506-8.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/00365527809181753","article-title":"Strong association between the HLA-Dw3, related B alloantigen DRw3 and coeliac disease","volume":"13","author":"Ek, J.; Albrechtsen, D.; Solheim, B.G.; Thorsby, E.","year":"1978","unstructured":"Ek J, Albrechtsen D, Solheim BG, Thorsby E. Strong association between the HLA-Dw3, related B alloantigen DRw3 and coeliac disease. Scand J Gastroenterol 1978; 13: 229-43.","journal-title":"Scand J Gastroenterol"},{"key":"ref_13","first-page":"952","article-title":"Immunoglobulin allotype markers in glutensensitive enteropathy","volume":"1","author":"Kagnoff, M.F.; Weiss, J.B.; Brown, R.J.; Lee, T.; Schanfield, M.S.","year":"1983","unstructured":"Kagnoff MF, Weiss JB, Brown RJ, Lee T, Schanfield MS. Immunoglobulin allotype markers in glutensensitive enteropathy. Lancet 1983; 1: 952-3.","journal-title":"Lancet"},{"key":"ref_14","first-page":"153","article-title":"B-cell alloantigens associated with coeliac disease","volume-title":"Genetics of coeliac disease","author":"McKenna, R.; Stevens, F.M.; Bourke, M.; McNicholl, B.; Albert, E.D.; McCarthy, C.F.","year":"1981","unstructured":"McKenna R, Stevens FM, Bourke M, McNicholl B, Albert ED, McCarthy CF. B-cell alloantigens associated with coeliac disease. In: McConnell RB, ed. Genetics of coeliac disease. 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Lancaster: MTP Press, 1978: 123-8."},{"key":"ref_17","first-page":"231","article-title":"Adult coeliac disease associated with HLA-DRw3 and DRw7","volume":"15","author":"L, Betuel H.Gebuhrer; L, Descos; Y, Percebois H.Minaire; J, Bertrand","year":"1980","unstructured":"Betuel H. Gebuhrer L, Descos L, Percebois H. Minaire Y, Bertrand J. Adult coeliac disease associated with HLA-DRw3 and DRw7. Tissue Antigens 1980; 15: 231-8.","journal-title":"Tissue Antigens"},{"key":"ref_18","first-page":"306","article-title":"Two HLA-D and DR alleles are associated with coeliac disease","volume":"14","author":"M, De Marchi; I, Borelli; E, Olivetti","year":"1979","unstructured":"De Marchi M, Borelli I, Olivetti E et al. Two HLA-D and DR alleles are associated with coeliac disease. Tissue Antigens 1979; 14: 306-16.","journal-title":"Tissue Antigens"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-94-011-8114-3_27","article-title":"Glutensensitive enteropathy in Spain: genetic and environmental factors","volume-title":"Genetics of coeliac disease","author":"Polanco, I.; Biemond, I.; van Leeuwen, A.","year":"1981","unstructured":"Polanco I, Biemond I, van Leeuwen A et al. Glutensensitive enteropathy in Spain: genetic and environmental factors. In: McConnell RB, ed. Genetics of coeliac disease. Lancaster: MTP Press, 1981: 211-31."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1399-0039.1981.tb00706.x","article-title":"Ashkenazi A et al. Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study","volume":"17","author":"Brautbar, C.; Fraier, S.","year":"1981","unstructured":"Brautbar C, Fraier S, Ashkenazi A et al. Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study. Tissue Antigens 1981; 17: 313-22.","journal-title":"Tissue Antigens"},{"key":"ref_21","first-page":"1571","article-title":"HLA-DR typing in coeliac disease: evidence for genetic heterogeneity","volume":"2","author":"Ellis, A.; Taylor, C.J.; Dillon-Rommy, M.; Woodrow, J.C.; McConnell, R.B.","year":"1984","unstructured":"Ellis A, Taylor CJ, Dillon-Rommy M, Woodrow JC, McConnell RB. HLA-DR typing in coeliac disease: evidence for genetic heterogeneity. Br Med J 1984; 2: 1571-3.","journal-title":"Br Med J"},{"key":"ref_22","first-page":"251","volume":"5","author":"Bodmer, J.; Bodmer, W.","year":"1984","unstructured":"Bodmer J, Bodmer W. Histocompatibility 1984. Immunol Today 1984; 5: 251-4.","journal-title":"Histocompatibility"},{"key":"ref_23","first-page":"1804","article-title":"Immunogenetic aspects of the relationship between HLA-DR and the MB","volume-title":"and MT systems. 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Histocompatibility testing 1980. Los Angeles: UCLA Tissue Typing Laboratory, 1980: 861-3."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/gut.24.8.706","article-title":"HLADR3 in coeliac disease: immunogenetic and clinical aspects","volume":"24","author":"M, De Marchi; A, Carbonara; N, Ansaldi","year":"1983","unstructured":"De Marchi M, Carbonara A, Ansaldi N et al. HLADR3 in coeliac disease: immunogenetic and clinical aspects. Gut 1983; 24: 706-13.","journal-title":"Gut"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0016-5085(78)90408-0","article-title":"Genetic basis of gluten-sensitive enteropathy","volume":"75","author":"Pena, A.S.; Mann, D.L.; Hague, N.E.","year":"1978","unstructured":"Pena AS, Mann DL, Hague NE et al. Genetic basis of gluten-sensitive enteropathy. Gastroenterology 1978; 75: 230-5.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.11.1210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:13:24Z","timestamp":1765649604000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.11.1210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1985,11,1]]},"published-print":{"date-parts":[[1985,11]]}},"alternative-id":["10.1136\/gut.26.11.1210"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.11.1210","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}