{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:53:37Z","timestamp":1774662817217,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>In 1964 Samman and White described 13 patients with lymphoedema of the lower extremities associated with an unusual dystrophy of the finger and toe nails: this they termed the 'yellow-nail' syndrome. Affected nails were thickened, excessively curved along both axes, very slow growing and of yellowish-grey hue; cuticle and lunula were usually absent and onycholysis was frequently evident. Lower limb lymphangiography in most individuals revealed hypoplasia, or aplasia of the lymphatics, similar to that occurring in primary lymphoedema: other patients also developed pleural effusions of high protein content or ascites suggestive of a more generalised disorder of the lymphatic system. Here we describe a patient in whom the classical 'yellow-nail' syndrome was associated with intestinal and chylous ascites.<\/jats:p>","DOI":"10.1136\/gut.26.11.1266","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1266-1269","source":"Crossref","is-referenced-by-count":31,"title":["Chylous ascites, intestinal lymphangiectasia and the 'yellow-nail' syndrome."],"prefix":"10.1136","volume":"26","author":[{"given":"P M","family":"Duhra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M N","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2133.1964.tb14499.x","article-title":"The \"yellow-nail\" syndrome","volume":"76","author":"Samman, P.D.; White, W.F.","year":"1964","unstructured":"Samman PD, White WF. The \"yellow-nail\" syndrome. Br J Dermatol 1964; 76: 153-7.","journal-title":"Br J Dermatol"},{"key":"ref_2","first-page":"37","article-title":"The yellow nail syndrome. Trans St John's Hosp Dermatol Soc","volume":"59","author":"Samman, P.D.","year":"1973","unstructured":"Samman PD. The yellow nail syndrome. Trans St John's Hosp Dermatol Soc 1973; 59: 37-8."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bjs.18004518902","article-title":"Primary lymphoedema: clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected","volume":"45","author":"Kinmonth, J.B.; Taylor, G.W.; Marsh, J.D.","year":"1957","unstructured":"Kinmonth JB, Taylor GW, Marsh JD. Primary lymphoedema: clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected. Br J Surg 1957; 45 1-10.","journal-title":"Br J Surg"},{"key":"ref_4","first-page":"247","article-title":"Yellow nail, lymphoedema and pleural effusions","volume-title":"Thorax","volume":"21","author":"Emerson, P.A.","year":"1966","unstructured":"Emerson PA. Yellow nail, lymphoedema and pleural effusions. Thorax 1966; 21 247-53."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1378\/chest.61.5.452","article-title":"Pulmonary manifestations of the yellow nail syndrome","volume":"61","author":"Hiller, E.; Rosenow, E.C.; Olsen, A.M.","year":"1972","unstructured":"Hiller E, Rosenow EC, Olsen AM. Pulmonary manifestations of the yellow nail syndrome. Chest 1972; 61: 452-8.","journal-title":"Chest"},{"key":"ref_6","first-page":"1093","article-title":"Yellow nails, lymphoedema and pleural effusions","volume":"73","author":"Dwek, J.H.; Greenberg, G.M.","year":"1973","unstructured":"Dwek JH, Greenberg GM. Yellow nails, lymphoedema and pleural effusions. N Y St J Med 1973; 73: 1093-7.","journal-title":"N Y St J Med"},{"issue":"58","key":"ref_7","first-page":"892","article-title":"Exudative enteropathy. A comparative study of 5'CrCl3 and 1311-PVP","volume":"1961","author":"TW, Rubini M.Sheehy","unstructured":"Rubini M. Sheehy TW. Exudative enteropathy. A comparative study of 5'CrCl3 and 1311-PVP. J Lab Clin Med 1961; 58: 892-8.","journal-title":"J Lab Clin Med"},{"key":"ref_8","first-page":"703","article-title":"Systemic lymphatic abnormalities associated with gastrointestinal protein loss secondary to intestinal lymphangiectasia. Gas- IES~~~~ troenterology","volume":"45","author":"Pomerantz, M.; Waldmann, T.A.","year":"1963","unstructured":"Pomerantz M, Waldmann TA. Systemic lymphatic abnormalities associated with gastrointestinal protein loss secondary to intestinal lymphangiectasia. Gas- IES~~~~ troenterology 1963; 45: 703-11."},{"key":"ref_9","first-page":"183","article-title":"The yellow nail syndrome. Light and electron microscopic aspects of the pleura","volume":"107","author":"Solal-Celigny, P.; Cormier, Y.; Fournier, M.","year":"1983","unstructured":"Solal-Celigny P, Cormier Y, Fournier M. The yellow nail syndrome. Light and electron microscopic aspects of the pleura. Arch Pathol Lab Med 1983; 107: 183-5.","journal-title":"Arch Pathol Lab Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/archderm.1970.04000120037006","article-title":"Yellow nails. A report of 6 cases","volume":"102","author":"Marks, R.; Ellis, J.P.","year":"1970","unstructured":"Marks R, Ellis JP. Yellow nails. A report of 6 cases. Arch Dermatol 1970; 102: 619-23.","journal-title":"Arch Dermatol"},{"key":"ref_11","first-page":"197","article-title":"Role of gastrointestinal system in \"idiopathic hypoproteinaemia\"","volume-title":"Gastroenterology 1961; 41","author":"Waldman, T.A.; Steinfeld, J.L.; Dutcher, T.F.; Davidson, J.D.; RS, Jr, Gordon","unstructured":"Waldman TA, Steinfeld JL, Dutcher TF, Davidson JD, Gordon RS Jr. Role of gastrointestinal system in \"idiopathic hypoproteinaemia\". Gastroenterology 1961; 41: 197-207."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(65)91657-0","article-title":"Intestinal lymphangiectasia. Mechanism of enteric loss of plasmaprotein and fat","volume":"1","author":"Mistilis, S.P.; Skyring, A.P.; Stephen, D.D.","year":"1965","unstructured":"Mistilis SP, Skyring AP, Stephen DD. Intestinal lymphangiectasia. Mechanism of enteric loss of plasmaprotein and fat. Lancet 1965; 1: 77-80.","journal-title":"Lancet"},{"key":"ref_13","first-page":"280","article-title":"Protein-losing enteropathy","volume-title":"disease - pathophysiology, diagnosis, management","author":"Jeffries, G.H.","year":"1983","unstructured":"Jeffries GH. Protein-losing enteropathy. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal disease - pathophysiology, diagnosis, management. Philadelphia, WB Saunders, 1983: 280-8."},{"key":"ref_14","first-page":"1004","article-title":"Electron microscopic study of the intestinal mucosa","volume-title":"intestinal lymphangiectasia. Gastroenterology 1966; 51","author":"WO, III, Dobbins","unstructured":"Dobbins WO III. Electron microscopic study of the intestinal mucosa in intestinal lymphangiectasia. Gastroenterology 1966; 51: 1004-17."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.7326\/0003-4819-61-3-385","article-title":"Hepatic hydrothorax: studies to intestinal lymphangiectasia. Central area of the villus is determine the source of the fluid and a report of occupied by grossly dilated lacteals: there is oedema of thirteen cases","volume":"61","author":"Johnson, L.F.; Loo, R.V.","year":"1964","unstructured":"Johnson LF, Loo RV. Hepatic hydrothorax: studies to intestinal lymphangiectasia. Central area of the villus is determine the source of the fluid and a report of occupied by grossly dilated lacteals: there is oedema of thirteen cases. Ann Intern Med 1964; 61: 385-401. remaining lamina propria, but epithelium is intact","journal-title":"Ann Intern Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.11.1266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:48:59Z","timestamp":1763747339000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.11.1266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1985,11,1]]},"published-print":{"date-parts":[[1985,11]]}},"alternative-id":["10.1136\/gut.26.11.1266"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.11.1266","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}