{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:56:45Z","timestamp":1790740605005,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:p>A joint prospective long term study of gastric biopsies has been undertaken to survey intestinal metaplasia Types I, II, and III in terms of their incidence, distribution and value in the selection of high risk cancer patients. This study is based on protocols agreed between three centres for endoscopy, histological interpretation, and mucin histochemistry. The results on the first 1350 gastric biopsies examined during 1981-1982 are presented. Intestinal metaplasia was found in 267 biopsies (20%), being common in association with carcinoma (71%), less so in benign conditions such as gastric ulcer (39%), and chronic gastritis (24%), but rare in 'normal' (3%). Type I intestinal metaplasia was predominant (73%) in all the biopsies with intestinal metaplasia and was most common in benign conditions, 70% in gastric ulcer and 76% in chronic gastritis. Type III intestinal metaplasia (incomplete sulphomucin-secreting intestinal metaplasia) was recorded in only 9.8% of all the biopsies with intestinal metaplasia and had a higher incidence in carcinoma (35%), than in benign conditions (7%) (p less than 0.0001). These results suggest that intestinal metaplasia types may have different malignant potential and their identification may be useful in screening patients for early detection of cancer.<\/jats:p>","DOI":"10.1136\/gut.26.12.1319","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1319-1326","source":"Crossref","is-referenced-by-count":161,"title":["Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres."],"prefix":"10.1136","volume":"26","author":[{"given":"M I","family":"Filipe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Potet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W V","family":"Bogomoletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Fabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Chauveinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fenzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gazzard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Goldfain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Zeegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jcp.33.8.711","article-title":"Precancerous conditions and epithelial dysplasia in the stomach","volume":"33","author":"Morson, B.C.; Sobin, L.H.; Grundmann, E.; Johansen, A.; Nagayo, T.; Serck-Hanssen, A.","year":"1980","unstructured":"Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A. Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 1980; 33: 711-21.","journal-title":"J Clin Pathol"},{"key":"ref_2","first-page":"351","article-title":"'Small intestinal type' and 'colonic type' intestinal metaplasia of the human stomach","volume":"86","author":"Teglbjaerg, P.S.; Nielsen, H.O.","year":"1978","unstructured":"Teglbjaerg PS, Nielsen HO. 'Small intestinal type' and 'colonic type' intestinal metaplasia of the human stomach. Acta Pathol Microbiol Scand 1978; 86: 351-5.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0344-0338(79)80047-3","article-title":"Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphological study","volume":"164","author":"Heilmann, K.L.; Hopker, W.W.","year":"1979","unstructured":"Heilmann KL, Hopker WW. Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphological study. Path Res Pract 1979; 164: 249-58.","journal-title":"Path Res Pract"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2559.1979.tb02996.x","article-title":"A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study","volume":"3","author":"Jass, J.; Filipe, M.I.","year":"1979","unstructured":"Jass J, Filipe MI. A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology 1979; 3: 191-9.","journal-title":"Histopathology"},{"key":"ref_5","first-page":"217","article-title":"Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma","volume":"88","author":"Sipponen, P.; Seppala, K.; Varis, K.","year":"1980","unstructured":"Sipponen P, Seppala K, Varis K, et al. Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma. [Abstract]. Acta Pathol Microbiol Scand 1980; 88: 217-224.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_6","first-page":"831","article-title":"The mucin profile of normal gastric epithelium, intestinal metaplasia and gastric carcinoma","volume":"13","author":"Jass, J.; Filipe, M.I.","year":"1981","unstructured":"Jass J, Filipe MI. The mucin profile of normal gastric epithelium, intestinal metaplasia and gastric carcinoma. Histochem J 1981; 13: 831-939.","journal-title":"Histochem J"},{"key":"ref_7","first-page":"408","article-title":"Histochemical characterization of different types of intestinal metaplasia in gastric mucosa","volume":"52","author":"Segura, D.I.; Montero, C.","year":"1983","unstructured":"Segura DI, Montero C. Histochemical characterization of different types of intestinal metaplasia in gastric mucosa. Cancer 1983; 52: 408-503.","journal-title":"Cancer"},{"key":"ref_8","article-title":"Histochemistry in pathology","author":"Filipe, M.I.; Lake, B.D.","year":"1983","unstructured":"Filipe MI, Lake BD. Histochemistry in pathology. London: Churchill Livingstone, 1983."},{"key":"ref_9","article-title":"Gastrointestinal pathology","author":"Morson, B.C.; Dawson, I.M.P.","year":"1979","unstructured":"Morson BC, Dawson IMP. Gastrointestinal pathology. 2nd ed. London: Blackwell, 1979.","edition":"2nd ed"},{"key":"ref_10","first-page":"231","article-title":"Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas","volume":"65","author":"Matsukura, N.; Suzuki, K.; Kawachi, T.","year":"1980","unstructured":"Matsukura N, Suzuki K, Kawachi T, et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl Cancer Inst 1980; 65: 231-40.","journal-title":"J Natl Cancer Inst"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1097-0142(19830915)52:6<1062::AID-CNCR2820520622>3.0.CO;2-P","article-title":"Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. A comparison with a representative population sample","volume":"52","author":"Sipponen, P.; Kekki, M.; Siurala, M.","year":"1983","unstructured":"Sipponen P, Kekki M, Siurala M. Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. A comparison with a representative population sample. Cancer 1983; 52: 1062-8.","journal-title":"Cancer"},{"key":"ref_12","first-page":"139","article-title":"Intestinal metaplasia and gastric carcinoma","volume":"13","author":"Sipponen, P.","year":"1981","unstructured":"Sipponen P. Intestinal metaplasia and gastric carcinoma. Ann Clin Res 1981; 13: 139-43.","journal-title":"Ann Clin Res"},{"key":"ref_13","article-title":"Sulphomucin-containing intestinal metaplasia in gastric biopsies - one year's experience","author":"Murray, L.A.; Williams, G.T.","year":"1984","unstructured":"Murray LA, Williams GT. Sulphomucin-containing intestinal metaplasia in gastric biopsies - one year's experience. [Abstract]. Pathological Society of Gt Britain & Ireland meeting. January 1984, London. (In press)."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.33.9.801","article-title":"Role of intestinal metaplasia in the histogenesis of gastric carcinoma","volume":"33","author":"Jass, J.","year":"1980","unstructured":"Jass J. Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol 1980; 33: 801-10.","journal-title":"J Clin Pathol"},{"key":"ref_15","first-page":"70","article-title":"Mucin histochemistry of gastric intestinal metaplasia","volume":"138","author":"Wells, M.; Stewart, M.; Dixon, M.F.","year":"1982","unstructured":"Wells M, Stewart M, Dixon MF. Mucin histochemistry of gastric intestinal metaplasia. [Abstract]. J Pathol 1982; 138: 70.","journal-title":"J Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two main histological types of gastric carcinomas; diffuse and so-called intestinal type carcinoma. An attempt at a histoclinical classification","volume":"64","author":"Lauren, P.","year":"1965","unstructured":"Lauren P. The two main histological types of gastric carcinomas; diffuse and so-called intestinal type carcinoma. An attempt at a histoclinical classification. Acta Pathol Microbiol Scand 1965; 64: 31.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1002\/1097-0142(197706)39:6<2475::AID-CNCR2820390626>3.0.CO;2-L","article-title":"Gastric carcinoma. A pathobiological classification","volume":"39","author":"Ming, S.-C.","year":"1977","unstructured":"Ming S-C. Gastric carcinoma. A pathobiological classification. Cancer 1977; 39: 2475-85.","journal-title":"Cancer"},{"key":"ref_18","first-page":"83","article-title":"Dysplastic changes in intestinal metaplasia of gastric mucosa","author":"Cuello, C.; Correa, P.","year":"1979","unstructured":"Cuello C, Correa P. Dysplastic changes in intestinal metaplasia of gastric mucosa. In: Herpath CL, Sehlag P, eds. Gastric cancer. Heidelberg: Springer-Verlag, 1979: 83-90."},{"key":"ref_19","first-page":"98","article-title":"The epidemiology and pathogenesis of chronic gastritis. Three aetiological entities","volume-title":"Frontiers of gastrointestinal research. Vol 6","author":"Correa, P.","year":"1980","unstructured":"Correa P. The epidemiology and pathogenesis of chronic gastritis. Three aetiological entities. In: van der Reis L, ed. Frontiers of gastrointestinal research. Vol 6. Basel: Karger, 1980: 98-108."},{"key":"ref_20","first-page":"2673","article-title":"Pre-cancerous changes in the stomach","volume":"36","author":"Kawachi, T.; Kurisu, M.; Numanyu, N.; Sasajima, K.; Sano, T.; Sugimura, T.","year":"1976","unstructured":"Kawachi T, Kurisu M, Numanyu N, Sasajima K, Sano T, Sugimura T. Pre-cancerous changes in the stomach. Cancer Res 1976; 36: 2673-7.","journal-title":"Cancer Res"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000478-197912000-00002","article-title":"Histopathology of gastric dysplasias","volume":"3","author":"Cuello, C.; Correa, P.; Zamara, G.; Lopez, J.; Murray, J.; Cordillo, C.","year":"1979","unstructured":"Cuello C, Correa P, Zamara G, Lopez J, Murray J, Cordillo C. Histopathology of gastric dysplasias. Am J Surg Pathol 1979; 3: 491-500.","journal-title":"Am J Surg Pathol"},{"key":"ref_22","first-page":"204","article-title":"Premalignant lesions - definitions","volume-title":"Kline and French (Proc. of 2nd BSG; SK and F. International Workshop, UK); gastric cancer","volume":"1981","author":"Crespi, M.","unstructured":"Crespi M. Premalignant lesions - definitions. In: Cotton PB, ed. Early gastric cancer. Tring: Smith, Kline and French (Proc. of 2nd BSG; SK and F. International Workshop, UK) 1981: 204."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2559.1980.tb02921.x","article-title":"Sulphomucins and precancerous lesions of the human stomach","volume":"4","author":"Jass, J.; Filipe, M.I.","year":"1980","unstructured":"Jass J, Filipe MI. Sulphomucins and precancerous lesions of the human stomach. Histopathology 1980; 4: 271-9.","journal-title":"Histopathology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2559.1983.tb02234.x","article-title":"A classification of gastric dysplasia","volume":"7","author":"Jass, J.","year":"1983","unstructured":"Jass J. A classification of gastric dysplasia. Histopathology 1983; 7: 181-93.","journal-title":"Histopathology"},{"key":"ref_25","first-page":"125","article-title":"Incidence of intestinal metaplasia subtypes in gastric biopsies collected over a 2-year period: Preliminary data from a joint prospective study in Britain and France","volume":"178","author":"Filipe, M.I.; Bogomoletz, V.; Dawson, P.; Fabiani, B.; Potet, F.","year":"1983","unstructured":"Filipe MI, Bogomoletz V, Dawson P, Fabiani B, Potet F. Incidence of intestinal metaplasia subtypes in gastric biopsies collected over a 2-year period: Preliminary data from a joint prospective study in Britain and France. [Abstract]. Path Res Pract 1983; 178: 125.","journal-title":"Path Res Pract"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1097-0142(19830715)52:2<353::AID-CNCR2820520229>3.0.CO;2-3","article-title":"Time trend in the prevalence of intestinal metaplasia in Japan","volume":"2","author":"Imai, T.; Murayama, H.","year":"1983","unstructured":"Imai T, Murayama H. Time trend in the prevalence of intestinal metaplasia in Japan. Cancer 1983; 2: 353-61.","journal-title":"Cancer"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.26.12.1319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:55:02Z","timestamp":1763747702000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.26.12.1319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1985,12,1]]},"published-print":{"date-parts":[[1985,12]]}},"alternative-id":["10.1136\/gut.26.12.1319"],"URL":"https:\/\/doi.org\/10.1136\/gut.26.12.1319","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}