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The liver and spleen size were not affected by plasmapheresis, and activities of aminotransferases, alkaline phosphatase and titres of mitochondrial antibody remained unchanged. We conclude that plasmapheresis has a role in the therapeutic management of patients with advanced primary biliary cirrhosis who are disabled by the complications of pruritus, xanthomatous neuropathy, or hypercholesterolemia with xanthoma formation.<\/jats:p>","DOI":"10.1136\/gut.26.3.291","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"291-294","source":"Crossref","is-referenced-by-count":74,"title":["Role of plasmapheresis in primary biliary cirrhosis."],"prefix":"10.1136","volume":"26","author":[{"given":"L B","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E P","family":"Ambinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Wolke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S P","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Schaffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0140-6736(81)92412-0","article-title":"Plasma exchange for hypercholesterolaemia","volume":"1","author":"Thompson, G.R.","year":"1981","unstructured":"Thompson GR. 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[Letter] N Engl J Med 1981; 302: 809.","journal-title":"[Letter] N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(77)92666-6","article-title":"Is primary biliary cirrhosis an immune complex disease?","volume":"2","author":"Thomas, H.C.; Potter, B.J.; Sherlock, S.","year":"1977","unstructured":"Thomas HC, Potter BJ, Sherlock S. Is primary biliary cirrhosis an immune complex disease? Lancet 1977; 2: 1261-3.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJM197802022980502","article-title":"Circulating immune complexes and complement activation in primary biliary cirrhosis","volume":"298","author":"Wands, K.R.; Dienstag, J.L.; Bhan, A.K.; Feller, E.R.; Isselbacher, K.J.","year":"1978","unstructured":"Wands KR, Dienstag JL, Bhan AK, Feller ER, Isselbacher KJ. Circulating immune complexes and complement activation in primary biliary cirrhosis. 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