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This is a promising agent both for acute treatment of peptide hypersecretion, and for the long term management of some patients who are unresponsive to other available therapy.<\/jats:p>","DOI":"10.1136\/gut.26.5.438","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"438-444","source":"Crossref","is-referenced-by-count":133,"title":["Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue symptomatic and peptide responses."],"prefix":"10.1136","volume":"26","author":[{"given":"S M","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Kraenzlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJM198203113061005","article-title":"Tumours of the endocrine pancreas","volume":"306","author":"Friesen, SR","year":"1982","unstructured":"Friesen SR. Tumours of the endocrine pancreas. N Engl J Med 1982; 306: 580-90.","journal-title":"N Engl J Med"},{"issue":"82","key":"ref_2","first-page":"165","article-title":"Gut hormone secreting tumours","volume":"18","author":"Wood, S.M.; Polak, J.M.; Bloom, SR","year":"1983","unstructured":"Wood SM, Polak JM, Bloom SR. Gut hormone secreting tumours. Scand J Gastroenterol 1983; 18: suppl 82: 165-79.","journal-title":"Scand J Gastroenterol"},{"key":"ref_3","first-page":"120","article-title":"The carcinoid syndromes","volume-title":"endocrinology: clinical syndromes","author":"Kaplan, E.L.","year":"1978","unstructured":"Kaplan EL. The carcinoid syndromes. In: Friesen SR, ed. Surgical endocrinology: clinical syndromes. Philadelphia: Lippincott, 1978: 120-47."},{"key":"ref_4","first-page":"103","article-title":"The mechanism of facial flushes in the carcinoid syndrome","volume":"21","author":"Robertson, J.I.S.; Peart, W.S.; Andrews, J.M.","year":"1962","unstructured":"Robertson JIS, Peart WS, Andrews JM. The mechanism of facial flushes in the carcinoid syndrome. Q J Med 1962; 21: 103-23.","journal-title":"Q J Med"},{"key":"ref_5","first-page":"476","article-title":"Rebound effect after somatostatin treatment in Verner Morrison syndrome","volume":"2","author":"Bonfils, S.; Rene, E.; Piginal, F.; Rambaud, J.C.","year":"1979","unstructured":"Bonfils S, Rene E, Piginal F, Rambaud JC. Rebound effect after somatostatin treatment in Verner Morrison syndrome. 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London: Churchill Livingstone, 1981: 581-5."},{"key":"ref_10","first-page":"50","article-title":"The metabolic clearance and plasma half disappearance time of exogenous somatostatin in man","volume":"49","author":"Sheppard, M.; Shapiro, B.; Pimstone, B.; Kronheim, M.B.; Gregory, M.","year":"1979","unstructured":"Sheppard M, Shapiro B, Pimstone B, Kronheim MB, Gregory M. The metabolic clearance and plasma half disappearance time of exogenous somatostatin in man. J Clin Endocrinol Metab 1979; 49: 50-3.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_11","first-page":"76","article-title":"Selective inhibition of glucagon and insulin secretion","volume-title":"by somatostatin analogues. Proc R Soc Med","volume":"160","author":"Bhathena, S.J.; Recant, L.; Meyers, L.A.; Coy, D.H.","year":"1979","unstructured":"Bhathena SJ, Recant L, Meyers LA, Coy DH. Selective inhibition of glucagon and insulin secretion by somatostatin analogues. 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Life Sci 1982; 31: 1133-40.","journal-title":"Life Sci"},{"key":"ref_14","article-title":"Radioimmunoassays of gut regulatory peptides","author":"Multiple authors. In, Bloom SR, Long RG","year":"1982","unstructured":"Multiple authors. In: Bloom SR, Long RG, eds. Radioimmunoassays of gut regulatory peptides London: Saunders, 1982."},{"key":"ref_15","first-page":"505","article-title":"Mixed pancreatic tumour syndrome with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide","volume-title":"Gut","volume":"22","author":"Long, R.G.; Bryant, M.G.; Yuille, P.M.; Bloom, SR","year":"1981","unstructured":"Long RG, Bryant MG, Yuille PM, Bloom SR. Mixed pancreatic tumour syndrome with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide. 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Berlin: SpringerVerlag, 1983."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000198619","article-title":"Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man","volume":"22","year":"1981","unstructured":"Johansson C, Wisen 0, Efendic S, Uvnas Wallenstein K. Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man. Digestion 1981; 22: 126-37.","journal-title":"Digestion"},{"key":"ref_21","first-page":"67","article-title":"In vitro effect of somatostatin on ion transport in rabbit intestine","volume":"238","author":"Guandalini, S.; Kachur, J.F.; Smith, P.L.; Miller, R.J.; Field, M.","year":"1980","unstructured":"Guandalini S, Kachur JF, Smith PL, Miller RJ, Field M. In vitro effect of somatostatin on ion transport in rabbit intestine. 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Effect of chronic administration of somatostain on rat exocrine pancreas. 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