{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:35:09Z","timestamp":1792445709964,"version":"4.5.0"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:p>Eighty two patients with an endoscopically healed gastric ulcer, were treated for two years with either Caved-S tablets, two twice daily or cimetidine 400 mg at night. During the first year, 12% (four out of 34) of the Caved-S group and 10% (four out of 41) of the cimetidine group had an ulcer recurrence. By the end of the second year, the recurrence rate was 29% (nine out of 31) in the Caved-S group, and 25% (eight out of 32) for the cimetidine group. Ulcer relapse occurred frequently in patients with either a dyspeptic history of over six months (p less than 0.05), or a past history of a gastric ulcer (p less than 0.001). Ulcers recurred rapidly after maintenance therapy; Caved-S two out of 22; cimetidine seven out of 23, within four months (NS). This study shows that long term maintenance therapy is safe and reasonably effective. The high recurrence rate after stopping treatment suggests that therapy in high risk or elderly patients should be for life.<\/jats:p>","DOI":"10.1136\/gut.26.6.599","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"599-602","source":"Crossref","is-referenced-by-count":18,"title":["Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence."],"prefix":"10.1136","volume":"26","author":[{"given":"A G","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pacsoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"McAdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/gut.23.6.545","article-title":"Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy","volume":"23","author":"Morgan, A.G.; McAdam, W.A.F.; Pacsoo, C.; Darnborough, A.","year":"1982","unstructured":"Morgan AG, McAdam WAF, Pacsoo C, Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut 1982; 23: 545-51.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto, R.","year":"1977","unstructured":"Peto R. et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part II. Br J Cancer 1977; 35: 1-39.","journal-title":"Part II. Br J Cancer"},{"key":"ref_3","article-title":"in the treatment of gastric ulceration (GU). Abstract E26.5 Cimetidine 2774 Hepatogastroenterology","volume":"205","year":"1980","unstructured":"in the treatment of gastric ulceration (GU). Abstract E26.5 Cimetidine 2774 Hepatogastroenterology 1980; suppl: 205."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/pgmj.55.644.393","article-title":"Cimetidine in the prevention of gastric ulcer relapse","volume":"55","author":"Machell, R.J.; Ciclitira, P.J.; Farthing, M.J.G.; Dick, A.P.; Hunter, J.O.","year":"1979","unstructured":"Machell RJ, Ciclitira PJ, Farthing MJG, Dick AP, Hunter JO. Cimetidine in the prevention of gastric ulcer relapse. Postgrad Med J 1979; 55: 393-5.","journal-title":"Postgrad Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/00365527909179865","article-title":"Prophylactic effect of cimetidine in gastric ulcer patients","volume":"14","author":"K, Birger Jensen; KM, M0llmann; I, Rahbek; J, Rask Madsen; SJ, Rune; HR, Wulff","year":"1979","unstructured":"Birger Jensen K, M0llmann KM, Rahbek I, Rask Madsen J, Rune SJ, Wulff HR. Prophylactic effect of cimetidine in gastric ulcer patients. 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A twoyear prospective controlled study of maintenance cimetidine and gastric ulcer. Gastroenterology 1983; 85: 100-4 8 Cockel R, Dawson J, Jain S. Ranitidine in the longterm treatment of gastric ulcers. In: Misiewicz JJ, Wormsley KG, eds. The clinical use of ranitidine Oxford: Medicine Publishing Foundation, 1982: 232-8."},{"issue":"78","key":"ref_8","first-page":"615","article-title":"Ranitidine in the treatment of gastric ulcers: healing and maintenance","volume":"17","author":"Hellier, M.D.; Gent, A.E.; Walker, J.; Britten, D.; Hutchison, C.; Gough, K.R.","year":"1982","unstructured":"Hellier MD, Gent AE, Walker J, Britten D, Hutchison C, Gough KR. Ranitidine in the treatment of gastric ulcers: healing and maintenance. Scand J Gastroenterol 1982; 17 suppl 78: 615.","journal-title":"Scand J Gastroenterol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/gut.24.5.418","article-title":"Ranitidine in the prevention of gastric and duodenal ulcer relapse","volume":"24","author":"Alstead, E.M.; Ryan, F.P.; Holdsworth, C.D.; Ashton, Moore; M.","year":"1983","unstructured":"Alstead EM, Ryan FP, Holdsworth CD, Ashton, Moore M. Ranitidine in the prevention of gastric and duodenal ulcer relapse. Gut 1983; 24: 418-20.","journal-title":"Gut"},{"key":"ref_10","series-title":"Proceedings of Glaxo International Symposium; Ranitidine, the selective new H2-receptor antagonist","first-page":"20","article-title":"Maintenance treatment with ranitidine in peptic ulceration","author":"Record, C.O.","year":"1982","unstructured":"Record CO. Maintenance treatment with ranitidine in peptic ulceration. In: Tytgat GN, ed. Ranitidine, the selective new H2-receptor antagonist. Proceedings of Glaxo International Symposium, Amsterdam, 17-18 September 1982. Guildford: Theracom, 1982: 20-4."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.20.6.526","article-title":"Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and longterm effects","volume":"20","author":"Dronfield, M.W.; Batchelor, A.J.; Larkworthy, W.; Langman, M.J.S.","year":"1979","unstructured":"Dronfield MW, Batchelor AJ, Larkworthy W, Langman MJS. Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and longterm effects. Gut 1979; 20: 526-30.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/bmj.1.6157.169","article-title":"Cimetidine and duodenal ulcer","volume":"1","author":"Baron, J.H.; Alexander-Williams, J.; Bennett, JR","year":"1979","unstructured":"Baron JH, Alexander-Williams J, Bennett JR. Cimetidine and duodenal ulcer. 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