{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:09:08Z","timestamp":1765609748535,"version":"3.48.0"},"reference-count":22,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:p>The effect of varying doses of cimetidine and omeprazole, on acute gastric mucosal lesions produced by topical aspirin (200 mg\/kg; 1 ml\/100 g) in 0.175 M HCl or topical sodium taurocholate (40 mM; 1 ml\/100 g) in 0.175 M HCl was studied in the pylorus ligated rat. Preliminary studies revealed dose dependent inhibition of acid secretion with both cimetidine and omeprazole. Intraperitoneal cimetidine 50 mg\/kg and 100 mg\/kg given before topical acidified aspirin reduced mucosal lesions from a control score of 23.7 +\/- 3.5 (mean +\/- SEM) in which 83% of stomachs contained lesions, to 6.9 +\/- 2.2 and 3.5 +\/- 2.1 respectively (p less than 0.05), 36% and 27% of stomachs containing lesions. A dose of 250 mg\/kg failed to reduce lesion score significantly (17.8 +\/- 4.9) and 64% of stomachs contained lesions. Taurocholate-induced lesion score was reduced from a control value of 32.7 +\/- 4.3 in which 97% of stomachs contained lesions to 10.8 +\/- 3.3 and 15.5 +\/- 3.8 by cimetidine 10 mg\/kg and 25 mg\/kg respectively (p less than 0.05), 62% and 68% of stomachs containing lesions. Cimetidine 50 mg\/kg and 100 mg\/kg failed to significantly reduce mucosal damage. Intraduodenal omeprazole (1.25 to 50 mumol\/kg) given before topical acidified aspirin or taurocholate failed to reduce mucosal lesions, as did intragastric omeprazole 5 mumol\/kg and 50 mumol\/kg given before acidified aspirin. Cimetidine showed cytoprotective properties over a specific dose range beyond which the effect was lost despite continuing suppression of acid secretion. Omeprazole exhibited no cytoprotective activity.<\/jats:p>","DOI":"10.1136\/gut.26.8.770","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"770-775","source":"Crossref","is-referenced-by-count":20,"title":["Effect of cimetidine and omeprazole on aspirin- and taurocholate-induced gastric mucosal damage in the rat."],"prefix":"10.1136","volume":"26","author":[{"given":"R J","family":"Utley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Salim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","article-title":"Cyto-protection by prostaglandins in rats","volume":"77","author":"Robert, A.; Nezamis, J.E.; Lancaster, C.; Hanchar, A.J.","year":"1979","unstructured":"Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cyto-protection by prostaglandins in rats. Gastroenterology 1979; 77: 433-43.","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"1229","article-title":"Cimetidine and prostaglandin: Evidence for different modes of action on the","volume-title":"rat gastric mucosa. Gastroenterology 1978; 4","author":"Carmichael, H.A.; Nelson, L.M.; Russell, R.I.","unstructured":"Carmichael HA, Nelson LM, Russell RI. Cimetidine and prostaglandin: Evidence for different modes of action on the rat gastric mucosa. Gastroenterology 1978; 4: 1229-32."},{"key":"ref_3","first-page":"1227","article-title":"Cyto-protection against acidified aspirin: comparison of prostaglandin, cimetidine and probanthine","volume":"76","author":"Robert, A.; Hanchar, A.J.; Nezamis, J.E.; Lancaster, C.","year":"1979","unstructured":"Robert A, Hanchar AJ, Nezamis JE, Lancaster C. Cyto-protection against acidified aspirin: comparison of prostaglandin, cimetidine and probanthine. 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