{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:55:00Z","timestamp":1765652100634,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:p>Symptomatic assessment and oesophageal investigations were done in 25 consecutive patients with the irritable bowel syndrome attending a gastroenterological clinic. Symptoms of gastro-oesophageal reflux, dysphagia, and a globus sensation were significantly commoner than in a control group of fracture clinic patients. Ambulatory oesophageal pH monitoring showed clearly abnormal reflux in 11 of 22 patients (50%). Nine patients had macroscopic endoscopic changes and a further 11 biopsy changes alone, of oesophagitis which was thus present in 80% overall. Lower oesophageal sphincter pressure was significantly less in irritable bowel patients than in age and sex matched controls, but upper oesophageal sphincter pressure was comparable in the two groups and disordered peristalsis was not found. Oesophageal symptoms in the irritable bowel syndrome are mainly caused by gastro-oesophageal reflux predisposed to by a subnormal lower oesophageal sphincter pressure, rather than by oesophageal spasm.<\/jats:p>","DOI":"10.1136\/gut.27.10.1127","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1127-1131","source":"Crossref","is-referenced-by-count":49,"title":["Gastro-oesophageal reflux in the irritable bowel syndrome."],"prefix":"10.1136","volume":"27","author":[{"given":"H L","family":"Smart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,10,1]]},"reference":[{"key":"ref_1","first-page":"387","article-title":"Globus and headache: common symptoms of the irritable bowel syndrome","volume":"118","author":"Watson, W.C.; Sullivan, S.N.; Corke, M.; Rush, D.","year":"1978","unstructured":"Watson WC, Sullivan SN, Corke M, Rush D. Globus and headache: common symptoms of the irritable bowel syndrome. Can Med Assoc J 1978; 118: 387-8.","journal-title":"Can Med Assoc J"},{"key":"ref_2","first-page":"1230","article-title":"Unrecognised common features of irritable bowel syndrome","volume":"76","author":"Rubin, L.; Wald, A.; Schuster, M.M.","year":"1979","unstructured":"Rubin L, Wald A, Schuster MM. Unrecognised common features of irritable bowel syndrome. [Abstracti. Gastroenterology 1979; 76: 1230A.","journal-title":"[Abstracti. Gastroenterology"},{"issue":"79","key":"ref_3","first-page":"16","article-title":"Symptoms in irritable bowel syndrome","volume":"17","author":"Dotevall, G.; Svedlund, J.; Sjodin, I.","year":"1982","unstructured":"Dotevall G, Svedlund J, Sjodin I. Symptoms in irritable bowel syndrome. Scanid J Gastroenterol 1982; 17: suppl. 79: 16-19.","journal-title":"Scanid J Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1136\/bmj.282.6270.1101","article-title":"Oesophageal motility in the irritable bowel syndrome","volume":"1","author":"Whorwell, P.J.; Clouter, C.; Smith, C.L.","year":"1981","unstructured":"Whorwell PJ, Clouter C, Smith CL. Oesophageal motility in the irritable bowel syndrome. Br Med J 1981; 1: 1101-2.","journal-title":"Br Med J"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/gut.25.4.375","article-title":"Jejunal motility in patients with functional abdominal pain","volume":"25","author":"Kingham, J.G.C.; Bown, R.; Colson, R.; Clark, M.L.","year":"1984","unstructured":"Kingham JGC, Bown R, Colson R, Clark ML. Jejunal motility in patients with functional abdominal pain. Gut 1984; 25: 375-80.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","article-title":"Towards positive diagnosis of the irritable bowel","volume":"2","author":"Manning, A.P.; Thompson, W.G.; Heaton, K.W.; Morris, A.F.","year":"1978","unstructured":"Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. Br Med J 1978; 2: 653-4.","journal-title":"Br Med J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0016-5085(19)32264-4","article-title":"Improved infusion system for intraluminal oesophageal manometry","volume":"73","author":"Arndorfer, R.C.; Stef, J.J.; Dodds, W.J.; Lineham, J.H.; Hogan, W.J.","year":"1977","unstructured":"Arndorfer RC, Stef JJ, Dodds WJ, Lineham JH, Hogan WJ. Improved infusion system for intraluminal oesophageal manometry. Gastroenterology 1977; 73: 23-7.","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/bjs.1800660206","article-title":"The reproducibility of the station pull through technique for measuring lower oesophageal sphincter pressure","volume":"66","author":"Hay, D.J.; Goodall, R.J.R.; Temple, J.G.","year":"1979","unstructured":"Hay DJ, Goodall RJR, Temple JG. The reproducibility of the station pull through technique for measuring lower oesophageal sphincter pressure. Br J Surg 1979; 66: 93-7.","journal-title":"Br J Surg"},{"key":"ref_9","series-title":"Gastroenterology 1985; 88","first-page":"1376","article-title":"Ambulatory monitoring of gastro-oesophageal pH using a radiotelemetry capsule and a new solid state recorder with automated analysis","author":"Evans, D.F.; Jones, J.A.; Hardcastle, J.D.","unstructured":"Evans DF, Jones JA, Hardcastle JD. Ambulatory monitoring of gastro-oesophageal pH using a radiotelemetry capsule and a new solid state recorder with automated analysis. [Abstract]. Gastroenterology 1985; 88: A1376."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/bjs.1800710607","article-title":"The evaluation of oesophageal reflux using a frequency duration index (FDI)","volume":"71","author":"Branicki, F.J.; Evans, D.F.; Jones, J.A.; Ogilvie, A.L.; Atkinson, M.; Hardcastle, J.D.","year":"1984","unstructured":"Branicki FJ, Evans DF, Jones JA, Ogilvie AL, Atkinson M, Hardcastle JD. The evaluation of oesophageal reflux using a frequency duration index (FDI). Br J Surg 1984; 71: 425-30.","journal-title":"Br J Surg"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1136\/gut.23.11.992","article-title":"Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system","volume":"23","author":"Branicki, F.J.; Evans, D.F.; Ogilvie, A.L.; Atkinson, M.; Hardcastle, J.D.","year":"1982","unstructured":"Branicki FJ, Evans DF, Ogilvie AL, Atkinson M, Hardcastle JD. Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system. Gut 1982; 23: 992-8.","journal-title":"Gut"},{"key":"ref_12","series-title":"Gut","first-page":"827","article-title":"Incidence of oesophageal symptoms in patients with irritable bowel syndromes","volume":"17","author":"Watson, W.C.; Sullivan, S.N.; Corke, M.; Rush, D.","year":"1976","unstructured":"Watson WC, Sullivan SN, Corke M, Rush D. Incidence of oesophageal symptoms in patients with irritable bowel syndromes. [Abstract]. Gut 1976; 17: 827A."},{"key":"ref_13","first-page":"46","article-title":"Heartburn and globus in apparently healthy people","volume":"126","author":"Thompson, W.G.; Heaton, K.W.","year":"1982","unstructured":"Thompson WG, Heaton KW. Heartburn and globus in apparently healthy people. Can Med Assoc J 1982; 126: 46-8.","journal-title":"Can Med Assoc J"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(74)90074-9","article-title":"Hypertonicity of the circopharyngeal sphincter: a cause of globus sensation","volume":"2","author":"Watson, W.C.; Sullivan, S.N.","year":"1974","unstructured":"Watson WC, Sullivan SN. Hypertonicity of the circopharyngeal sphincter: a cause of globus sensation. Lancet 1974; 2: 1417.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00004836-198212000-00006","article-title":"The prevalence and significance of gastritis in patients with lower intestinal irritable bowel (irritable colon) syndrome","volume":"4","author":"Fielding, J.F.; Doyle, G.D.","year":"1982","unstructured":"Fielding JF, Doyle GD. The prevalence and significance of gastritis in patients with lower intestinal irritable bowel (irritable colon) syndrome. J Clin Gastroenterol 1982; 4: 507-10.","journal-title":"J Clin Gastroenterol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0016-5085(76)80141-2","article-title":"Colonic myoelectrical activity in the irritable bowel syndrome","volume":"70","author":"Snape, W.J.; Carlson, G.M.; Cohen, S.","year":"1976","unstructured":"Snape WJ, Carlson GM, Cohen S. Colonic myoelectrical activity in the irritable bowel syndrome. Gastroenterology 1976; 70: 326-30.","journal-title":"Gastroenterology"},{"key":"ref_17","first-page":"61","article-title":"Vagal impairment in reflux oesophagitis","volume":"54","author":"Ogilvie, A.L.; James, P.D.; Atkinson, M.","year":"1985","unstructured":"Ogilvie AL, James PD, Atkinson M. Vagal impairment in reflux oesophagitis. Q J Med 1985; 54: 61-74.","journal-title":"Q J Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.10.1127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:51:55Z","timestamp":1765651915000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.10.1127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1986,10,1]]},"published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1136\/gut.27.10.1127"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.10.1127","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1986,10]]}}}