{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:59:21Z","timestamp":1791057561052,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,10,1]]},"DOI":"10.1136\/gut.27.10.1210","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:41:31Z","timestamp":1190151691000},"page":"1210-1212","source":"Crossref","is-referenced-by-count":243,"title":["Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis."],"prefix":"10.1136","volume":"27","author":[{"given":"R W","family":"Chapman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W S","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","article-title":"Cortisone in ulcerative colitis. Final report on a therapeutic trial","volume":"2","author":"Truelove, S.C.; Witts, L.J.","year":"1955","unstructured":"Truelove SC, Witts LJ. Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J 1955; 2: 1041-48.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0140-6736(74)90552-2","article-title":"Intensive intravenous regimen for severe attacks of ulcerative colitis","volume":"i:","author":"Truelove, S.C.; Jewell, D.P.","year":"1974","unstructured":"Truelove SC, Jewell DP. Intensive intravenous regimen for severe attacks of ulcerative colitis. Lancet 1974; i: 1067-70.","journal-title":"Lancet"},{"key":"ref_3","first-page":"456","article-title":"Diagnosis aind medical treatment of ulcerative colitis","volume":"27","author":"Jewell, D.P.","year":"1982","unstructured":"Jewell DP. Diagnosis aind medical treatment of ulcerative colitis. Br J Hosp Med 1982; 27: 456-62.","journal-title":"Br J Hosp Med"},{"issue":"2","key":"ref_4","first-page":"1708","article-title":"Comparison of corticosteroid and sulphalsazine therapy in ulcerative colitis","volume":"1962","author":"G, Truelove S.C.Watkinson; G, Draper","unstructured":"Truelove SC. Watkinson G, Draper G. Comparison of corticosteroid and sulphalsazine therapy in ulcerative colitis. Br Med J 1962; 2: 1708-1 1.","journal-title":"Br Med J"},{"key":"ref_5","first-page":"437","article-title":"Controlled trial of sulphasalazine in the treatment of ulcerative colitis","volume":"5","author":"Dick, A.P.; Grayson, M.J.; Carpenter, R.G.; Petrie, A.","year":"1964","unstructured":"Dick AP, Grayson MJ, Carpenter RG, Petrie A. Controlled trial of sulphasalazine in the treatment of ulcerative colitis. Giii 1964; 5: 437-42.","journal-title":"Giii"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1136\/gut.26.12.1380","article-title":"Double blind controlled trial of oral vancomycirn as adjunctive treatment in acute exacerbations of ulcerative colitis","volume":"26","author":"Dickinson, R.J.; O'Connor, H.J.; Pinder, I.; Hamilton, I.; Johnson, D.; Axon, A.T.R.","year":"1985","unstructured":"Dickinson RJ, O'Connor HJ, Pinder I, Hamilton I, Johnson D, Axon ATR. Double blind controlled trial of oral vancomycirn as adjunctive treatment in acute exacerbations of ulcerative colitis. Gut 1985; 26: 1380-4.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000231857","article-title":"Suppression of cell mediated immunity by metronidazole","volume":"54","author":"Grove, G.I.; Mahmoud, A.A.F.; Warren, K.S.","year":"1977","unstructured":"Grove GI, Mahmoud AAF, Warren KS. Suppression of cell mediated immunity by metronidazole. Ihit Arch Allergy Appl Immtuiol 1977; 54: 422-7.","journal-title":"Ihit Arch Allergy Appl Immtuiol"},{"key":"ref_8","first-page":"55","article-title":"A comparative study of metronidazole and sulfasalazine for active Crohn's disecase: the Cooperative Crohn's Disease Study in Sweden","volume":"83","author":"Ursing, B.; Alm, T.; Barany, F.","year":"1982","unstructured":"Ursing B, Alm T, Barany F, et al. A comparative study of metronidazole and sulfasalazine for active Crohn's disecase: the Cooperative Crohn's Disease Study in Sweden. II Result Gastroeniterology 1982; 83: 55(t-62.","journal-title":"II Result Gastroeniterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1099\/00222615-9-2-129","article-title":"Clostridium difficile: isolation and characteristics","volume":"9","author":"Hafiz, S.; Oakley, C.L.","year":"1976","unstructured":"Hafiz S, Oakley CL. Clostridium difficile: isolation and characteristics. J Med Microbiol 1976; 9: 129-37.","journal-title":"J Med Microbiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/jcp.32.3.303","article-title":"A micromethod for detecting toxins in pseudomembranous colitis","volume":"32","author":"George, R.H.","year":"1979","unstructured":"George RH. A micromethod for detecting toxins in pseudomembranous colitis. J Cltin Pathol 1979; 32: 303-4.","journal-title":"J Cltin Pathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(80)90940-X","article-title":"Clostridium difficile associated diarrhoea: a role in inflammatory bowel disease","volume":"i:","author":"Bolton, R.P.; Sheriff, R.J.; Rcad, A.E.","year":"1980","unstructured":"Bolton RP, Sheriff RJ, Rcad AE. Clostridium difficile associated diarrhoea: a role in inflammatory bowel disease. Lancet 1980; i: 383-4.","journal-title":"Lancet"},{"key":"ref_12","first-page":"687","article-title":"Occurrence of clostridium difficile toxin occurring during the course of inflammatory bowel disease","volume":"80","year":"1981","unstructured":"Meyers S, Mayer L, Bottone E, Desmond E, Janowitz MD. Occurrence of clostridium difficile toxin occurring during the course of inflammatory bowel disease. Gastroenterology 1981; 80: 687-700.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.10.1210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:16:59Z","timestamp":1601090219000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.10.1210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10,1]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1986,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/gut.27.10.1210","relation":{},"ISSN":["0017-5749"],"issn-type":[{"value":"0017-5749","type":"print"}],"subject":[],"published":{"date-parts":[[1986,10,1]]}}}