{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:51:15Z","timestamp":1763743875336,"version":"3.45.0"},"reference-count":13,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:p>Counts of T-lymphocytes within surface and crypt epithelium and lamina propria of normal and coeliac small intestinal mucosa using an immunoperoxidase method are described and related statistically to changes in mucosal structure determined by quantitative histology. The use of multiple pan-T-lymphocyte and subset antibodies allowed comparison of marker patterns in normal and abnormal mucosa. Total numbers of surface epithelial T-lymphocytes and subtypes were not found to be increased in coeliac disease, but there was an increase in density per unit length of epithelium. Distinctive changes in expression of Leu 1, Leu 2, and Leu 5 by the surface epithelial T-lymphocytes suggest that, although their total numbers are not increased, these cells are not passively crowded but have an active role, possibly as committed cytotoxic lymphocytes. Natural killer cells do not appear to be a major population in normal or coeliac small intestinal mucosa.<\/jats:p>","DOI":"10.1136\/gut.27.11.1330","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1330-1337","source":"Crossref","is-referenced-by-count":38,"title":["T-lymphocyte populations in normal and coeliac small intestinal mucosa defined by monoclonal antibodies."],"prefix":"10.1136","volume":"27","author":[{"given":"D","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Goodall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B B","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00007890-197306000-00005","article-title":"Histopathology and time course of rejection of allografts of mouse small intestine","volume":"15","author":"Ferguson, A.; Parrott, D.M.V.","year":"1973","unstructured":"Ferguson A, Parrott DMV. 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Scand J Gastroenterol 1985; 20: suppl 114: 55-75.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/gut.25.2.158","article-title":"Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased?","volume":"25","author":"Corazzo, G.R.; Frazzoni, M.; Gasbarrini, G.","year":"1984","unstructured":"Corazzo GR, Frazzoni M, Gasbarrini G. Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased? Gut 1984; 25: 158-62.","journal-title":"Gut"},{"key":"ref_9","first-page":"453","article-title":"T lymphocyte subsets in normal intestinal mucosa - the distribution and relationship to MHC-derived antigens. Clin Exp Immunol","volume":"44","author":"Selby, W.S.; Janossy, G.; Goldstein, G.; Jewell, D.P.","year":"1981","unstructured":"Selby WS, Janossy G, Goldstein G, Jewell DP. T lymphocyte subsets in normal intestinal mucosa - the distribution and relationship to MHC-derived antigens. Clin Exp Immunol 1981; 44: 453-8."},{"key":"ref_10","first-page":"\"219","article-title":"Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol 14 Scott BB","volume":"52","author":"Selby, W.S.; Janossy, G.; Bofill, M.A.; Jewell, D.P.","year":"1983","unstructured":"Selby WS, Janossy G, Bofill MA, Jewell DP. Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol 14 Scott BB, Jenkins D. Endoscopic small intestinal 1983; 52: 219-28. biopsy. Gastrointestinal endoscopy 1981; 27: 162-7."},{"article-title":"Detection of antibodies which 15 Cerf-Bensussan N, Guy-Grand D, Griscelli C. Intracan cooperate with lymphocytes. Lancet 1972; 2: 403-6. epithelial lymphocytes of human gut: isolation, charac-","author":"Fakhri 0, Hobbs JR","key":"ref_11","unstructured":"Fakhri 0, Hobbs JR. Detection of antibodies which 15 Cerf-Bensussan N, Guy-Grand D, Griscelli C. Intracan cooperate with lymphocytes. Lancet 1972; 2: 403-6. epithelial lymphocytes of human gut: isolation, charac-"},{"key":"ref_12","first-page":"26","article-title":"Hybridomas, monoclonal cells and terisation and study of natural killer activity. Gut 1985; analysis of the immune system","volume":"40","author":"Beverley, P.C.L.","year":"1984","unstructured":"Beverley PCL. Hybridomas, monoclonal cells and terisation and study of natural killer activity. Gut 1985; analysis of the immune system. Br Med Bull 1984; 40: 26: 81-8.","journal-title":"Br Med Bull"},{"key":"ref_13","series-title":"J Clin Lab Immunol","first-page":"26","article-title":"lymphocytes today. Amsterdam: activated cell sorter","author":"Inglis, JR","year":"1983","unstructured":"Inglis JR, ed. T lymphocytes today. Amsterdam: activated cell sorter. J Clin Lab Immunol 1983; 10: Elsevier, 1983: 26-9."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.11.1330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:48:32Z","timestamp":1763743712000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.11.1330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":13,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1986,11,1]]},"published-print":{"date-parts":[[1986,11]]}},"alternative-id":["10.1136\/gut.27.11.1330"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.11.1330","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}