{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:25:53Z","timestamp":1757780753443,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:p>Transdermal scopolamine is an antimuscarinic preparation approved for use in the United States for prevention of motion sickness. A recent study using this drug (0.5 mg\/patch) suggested that enough scopolamine was absorbed through the skin to reduce basal gastric acid secretion in patients with duodenal ulcer. We have compared the effect of transdermal scopolamine and oral cimetidine (400 mg twice daily) in seven men with chronic duodenal ulcer, both alone and in combination, on acid secretion throughout an entire 24 hour period in a placebo-controlled, randomised, double blinded cross over study. The effect of these drugs on basal, interprandial, and nocturnal gastric juice volume and hydrogen ion concentration also was measured. Transdermal scopolamine had no significant effect on mean 24 hour acid secretion (placebo, 409.4 mmol\/day; scopolamine, 364.0 mmol\/day) nor did it have a significant effect on gastric juice volume or hydrogen ion concentration. The combination of transdermal scopolamine plus cimetidine was not more effective than cimetidine alone in reducing total 24 hour acid secretion (mean, 231.8 versus 235.3 mmol\/day) nor in reducing gastric juice volume or hydrogen ion concentration.<\/jats:p>","DOI":"10.1136\/gut.27.12.1493","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1493-1497","source":"Crossref","is-referenced-by-count":11,"title":["Effects of transdermal scopolamine, alone or in combination with cimetidine, on total 24 hour gastric acid secretion in patients with duodenal ulcer."],"prefix":"10.1136","volume":"27","author":[{"given":"C T","family":"Richardson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM198411223112113","article-title":"Transdermal scopolaminc and basal acid secretion","volume":"311","author":"CH, I.Gleiter; KH, Antonin; T, Brodrick; RP, Bieck; G, Brcucha","year":"1984","unstructured":"I Gleiter CH, Antonin KH, Brodrick T, Bieck RP, Brcucha G. Transdermal scopolaminc and basal acid secretion. N Engl J Med 1984; 311: 1378.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1136\/bmj.284.6331.1736","article-title":"Effcct of transdermally administered hyoscinc methobromide on nocturnal acid secretion in patients with duodenal ulcer","volume":"284","author":"Walt, R.P.; Kalman, C.J.; Hunt, R.H.; Misiewicz, J.J.","year":"1982","unstructured":"Walt RP, Kalman CJ, Hunt RH, Misiewicz JJ. Effcct of transdermally administered hyoscinc methobromide on nocturnal acid secretion in patients with duodenal ulcer. Br Med J 1982; 284: 1736-8.","journal-title":"Br Med J"},{"key":"ref_3","first-page":"9","article-title":"Cimetidinie: twice dailly administration in duodenal ulcer - results of a UK and Irelanld n1ulticentre study","volume-title":"C(inctitline in 11te O's","author":"Kerr, G.D.","year":"1981","unstructured":"Kerr GD. Cimetidinie: twice dailly administration in duodenal ulcer - results of a UK and Irelanld n1ulticentre study. In: Baron JiH, ed. C(inctitline in 11te O's. Edinburgh: Churchill Livingstonce 1981: 9-13."},{"key":"ref_4","first-page":"14","article-title":"Cimetidine: twicc daily aidiiilistriationi in duodenal ulcer - results of a European niulticelltr-e study","volume-title":"in Hwe SO's","author":"Eckardt, V.","year":"1981","unstructured":"Eckardt V. Cimetidine: twicc daily aidiiilistriationi in duodenal ulcer - results of a European niulticelltr-e study. In: Baron JH, ed. Cinmeti(line in Hwe SO's. Edinburgh: Churchill Livingstone. 1981: 14-20."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1056\/NEJM197712292972603","article-title":"Effect of low-dose propanthelire on l'oodstimulated gastric acid secretion: comparison with an ''optimal eftective dose\"","volume":"297","author":"WalshllJ, Feldmatn M.N.Richardson C.T.Petersoni Wl; JS, Fordtran","year":"1977","unstructured":"Feldmatn MN Richardson CT. Petersoni Wl. WalshllJ, Fordtran JS. Effect of low-dose propanthelire on l'oodstimulated gastric acid secretion: comparison with an ''optimal eftective dose\" and interaction with cimetidine. N Enigl J Med 1977; 297: 1427-30.","journal-title":"Enigl J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF01296756","article-title":"Effect of isopropramide on response to oral cimetidine in patients with ZollingerEllison syndrome","volume":"27","author":"McCarthy, D.M.; Hyman, P.E.","year":"1982","unstructured":"McCarthy DM, Hyman PE. Effect of isopropramide on response to oral cimetidine in patients with ZollingerEllison syndrome. Dig Dis Sci 1982; 27: 353-9.","journal-title":"Dig Dis Sci"},{"key":"ref_7","first-page":"428","article-title":"Total 24-hour gastric acid secretion in patients with duodenal ulcer: comparison with normal subjects and effects of cimetidine and parietal cell vagotomy","volume":"90","author":"Feldman, M.; Richardson, C.T.","year":"1986","unstructured":"Feldman M, Richardson CT. Total 24-hour gastric acid secretion in patients with duodenal ulcer: comparison with normal subjects and effects of cimetidine and parietal cell vagotomy. Gastroenterologv 1986; 90: 428-33.","journal-title":"Gastroenterologv"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0016-5085(79)91324-6","article-title":"Comparison of acid secretioni rates measured by gastric aspiration and by in ivo intragastric titration in healthy human subjects","volume":"76","author":"Feldman, M.","year":"1979","unstructured":"Feldman M. Comparison of acid secretioni rates measured by gastric aspiration and by in ivo intragastric titration in healthy human subjects. Gastroenterologi\\ 1979; 76: 954-7.","journal-title":"Gastroenterologi\\"},{"issue":"49","key":"ref_9","first-page":"178","article-title":"The determination of gastric acidity by the glass electrode","volume":"1965","author":"Moore, E.W.; Scarlata, R.W.","unstructured":"Moore EW, Scarlata RW. The determination of gastric acidity by the glass electrode. Gaslroenterologs 1965: 49: 178-88.","journal-title":"Gaslroenterologs"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1172\/JCI107226","article-title":"Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer","volume":"52","author":"Fordtran, J.S.; Walsh, J.H.","year":"1973","unstructured":"Fordtran JS, Walsh JH. Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. J Clin Invest 1973; 52: 645-57.","journal-title":"J Clin Invest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.0954-6820.1965.tb01819.x","article-title":"Effect of poldine, glycopyrrolate and 1-hyoscyamine on giastric secretion of acid in man","volume":"177","author":"Dotevall, G.; Schroder, G.; Walan, A.","year":"1965","unstructured":"Dotevall G, Schroder G, Walan A. Effect of poldine, glycopyrrolate and 1-hyoscyamine on giastric secretion of acid in man. Acta Med Scanid 1965; 177: 169-74.","journal-title":"Acta Med Scanid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/2261261a0","article-title":"Circadian rhythm of gastric acid secretion in man","volume":"226","author":"E, Moore J.G.Englert","year":"1970","unstructured":"Moore JG. Englert E. Circadian rhythm of gastric acid secretion in man. Nature 1970; 226: 1261-2.","journal-title":"Nature"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.12.1493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:24:08Z","timestamp":1757273048000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.12.1493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1986,12,1]]},"published-print":{"date-parts":[[1986,12]]}},"alternative-id":["10.1136\/gut.27.12.1493"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.12.1493","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}