{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:49:10Z","timestamp":1790819350715,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:p>The discovery of the accessory duct of the pancreas is usually ascribed to Giovanni Domenico Santorini (1681-1737), after whom this structure is named. The papilla duodeni (ampulla 'of Vater', or papilla 'of Santorini') is named after Abraham Vater (1684-1751) or after GD Santorini. Pancreas divisum, a persistence through non-fusion of the embryonic dorsal and ventral pancreas is a relatively common clinical condition, the discovery of which is usually ascribed to Joseph Hyrtl (1810-1894). In this review I report that pancreas divisum, the accessory duct and the papilla duodeni (ampulla 'of Vater') had all been observed and the observations published during the 17th century by at least seven anatomists before Santorini, Vater, and Hyrtl. I further suggest, in the light of frequent anatomical misattributions in common usage, that anatomical structures be referred to only by their proper anatomical names.<\/jats:p>","DOI":"10.1136\/gut.27.2.203","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"203-212","source":"Crossref","is-referenced-by-count":68,"title":["A historical perspective on the discovery of the accessory duct of the pancreas, the ampulla 'of Vater' and pancreas divisum."],"prefix":"10.1136","volume":"27","author":[{"given":"C D","family":"Stern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,2,1]]},"reference":[{"key":"ref_1","article-title":"Boyd and Mossman's Human Embryology","author":"Hamilton, W.J.","year":"1976","unstructured":"Hamilton WJ, Mossman HW, eds. Hamilton, Boyd and Mossman's Human Embryology. 4th ed. London: Williams and Wilkins, 1976.","edition":"4th ed"},{"key":"ref_2","article-title":"Gray's anatomy","author":"Williams, P.L.","year":"1980","unstructured":"Williams PL, Warwick R, eds. Gray's anatomy. 36th ed. Edinburgh: Churchill Livingstone, 1980.","edition":"36th ed"},{"key":"ref_3","first-page":"404","article-title":"Pancreas divisum and pancreatitis","volume-title":"disease in clinical practice","author":"Mitchell, C.J.","year":"1981","unstructured":"Mitchell CJ. Pancreas divisum and pancreatitis. In: Mitchell CJ, Kelleher J, eds. Pancreatic disease in clinical practice. London: Pitman, 1981: 404-14."},{"key":"ref_4","first-page":"105","article-title":"Congenital anomaly of pancreas divisum as cause of obstructive pain and pancreatitis","volume-title":"Gut","volume":"21","author":"Cotton, P.B.","year":"1980","unstructured":"Cotton PB. Congenital anomaly of pancreas divisum as cause of obstructive pain and pancreatitis. Gut 1980; 21: 105-14."},{"issue":"52","key":"ref_5","first-page":"275","article-title":"Ein pancreas accessorium und Pancreas Divisum","volume":"1865","author":"Hyrtl, J.","unstructured":"Hyrtl J. Ein pancreas accessorium und Pancreas Divisum. Sitz. Mathematisch-Naturwiss. Classe d K Akad Wissenschaften (Wien) 1865; 52: 275.","journal-title":"Sitz. Mathematisch-Naturwiss. Classe"},{"key":"ref_6","article-title":"Septendecim tabulae quas nunc primum edit atque explicat iisque alias addit de structura Parmensi universitate anatomes professor primarius, etc. 1775; Parmae ex regia typographia. Fol","volume-title":"Adenographia sive glandularum totius corporis descriptio","volume":"8","author":"Santorini, G.D.","year":"Med.).","unstructured":"Santorini GD. Septendecim tabulae quas nunc primum edit atque explicat iisque alias addit de structura Parmensi universitate anatomes professor primarius, etc. 1775; Parmae ex regia typographia. Fol. (British Library 59.f.12; Wellcome Institute Hist. Med.). 8 Wharton T. Adenographia sive glandularum totius corporis descriptio. London: 8vo. 1656. (Cambridge Univ. Library K. 12.7 and P*.6.26(F)). Other editions: Amsterdam 1659, 12mo (Cambridge U.L. Hh. 19.29), Noviomagi 1665, 12mo. (Cambridge U.L. K.18.110), Vesaliae 1671, 12mo., Geneva 1685, fol."},{"key":"ref_7","first-page":"53","article-title":"Mantissa anatomica, extat cum Thom. Bartholini historiarum anatomicar. and medicar. rarior. Centuria V and VI. 1661; Hafniae 8vo","volume":"10","author":"Rhodius, J.","year":"1974","unstructured":"Rhodius J. Mantissa anatomica, extat cum Thom. Bartholini historiarum anatomicar. and medicar. rarior. Centuria V and VI. 1661; Hafniae 8vo. (Cambridge Univ Library N*.14.14(F). 10 Premuda L, Gamba A, Per la biografia di J. G. Wirsung e per la storia della scoperta del dotto pancreatico. Acta Med Hist Patav 1974; 21: 53-88.","journal-title":"Acta Med Hist Patav; Wirsung e per la storia della scoperta del dotto pancreatico"},{"key":"ref_8","first-page":"85","article-title":"Rhode in Padua des 17","volume":"14","author":"Snorrason, E.; Johan, Der Dane","year":"1967","unstructured":"Snorrason E, Der Dane Johan Rhode in Padua des 17.Jahrhunderts. Acta Med Hist Patav 1967; 14: 85-120.","journal-title":"Jahrhunderts. Acta Med Hist Patav"},{"key":"ref_9","article-title":"Dissertatio anatomica qua novum bilis diverticulum circa orificium ductus cholodochi ut et valvulosam colli vesicae felleae constructionem","author":"Vater, A.","year":"1329","unstructured":"Vater A. Dissertatio anatomica qua novum bilis diverticulum circa orificium ductus cholodochi ut et valvulosam colli vesicae felleae constructionem... 1720; Wittenbergae, Lit. Gerdesianus, 4to. (Wellcome Inst Hist Med A.I.f(20) 13298)."},{"key":"ref_10","first-page":"149","article-title":"The Santorini valves","volume":"48","author":"Velasco-Suarez, C.","year":"1981","unstructured":"Velasco-Suarez C. The Santorini valves. Mt Sinai J Med (NY) 1981; 48: 149-57.","journal-title":"Mt Sinai J Med (NY)"},{"key":"ref_11","article-title":"Histoire de l'anatomie et de la chirurgie, contenant l'origine et les progres de ces Sciences. Avec un Tableau Chronologique des principales decouvertes, et un catalogue des ouvrages d'Anatomie","author":"Portal, A.","unstructured":"Portal A. Histoire de l'anatomie et de la chirurgie, contenant l'origine et les progres de ces Sciences. Avec un Tableau Chronologique des principales decouvertes, et un catalogue des ouvrages d'Anatomie... 1770-1773; Paris, 8vo. (6 vols.) (Department of Anatomy, Stern Cambridge, L.2.5-10)."},{"key":"ref_12","author":"editeinedite delle vite, Atti G.Notizie","year":"1847","unstructured":"Atti G. Notizie edite ed inedite delle vite e delle opere di Marcello Malpighi e di Lorenzo Bellini. 1847; Bologna."},{"key":"ref_13","article-title":"Marcello Malpighi and the evolution of embryology","author":"Adelmann, H.","year":"1966","unstructured":"Adelmann H. Marcello Malpighi and the evolution of embryology. (5 vols.) 1966; Ithaca (NY): Cornell University Press."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.2.203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:17:09Z","timestamp":1765660629000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.2.203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1986,2,1]]},"published-print":{"date-parts":[[1986,2]]}},"alternative-id":["10.1136\/gut.27.2.203"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.2.203","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}