{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:19:48Z","timestamp":1771640388611,"version":"3.50.1"},"reference-count":39,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>This study was initiated to determine if raised (carcinoid) plasma concentrations of substance P induced jejunal secretion of water and electrolytes. Five dogs had isolated and cannulated 25 cm jejunal segments perfused at 2 ml\/min with a neutral, isotonic perfusate. Saline, 1.0 ml, was infused intravenously during basal and recovery periods, while substance P was administered intravenously at 75 ng\/kg\/min (55 pmol\/kg\/min) during the four 15 minute experimental periods. Infusion increased plasma SP concentrations from basal (5.8 +\/- 1.3 pg\/ml) to a mean plateau level of 121.2 +\/- 25.2 pg\/ml (mean +\/- SEM). During SP infusion, intestinal secretion of water, Na+, and Cl- were documented (H2O basal +102 +\/- 60 to SP -275 +\/- 60; microliter\/min; Na+ basal +19.8 +\/- 7.2 to SP -23.2 +\/- 7.5 microEq\/min; Cl- basal 21.7 +\/- 7.5 to SP -16.5 +\/- 5.6 microEq\/min). Under basal conditions, there was minimal secretion of potassium (-0.264 +\/- 0.282 microEq\/min); during SP infusion, K+ flux was altered to significant secretion (-1.784 +\/- 0.271 microEq\/min). Serum concentrations of Na and Cl were unchanged during SP infusion, but serum potassium concentrations fell from 4.64 +\/- 0.12 to 3.85 +\/- 0.40 mEq\/l. The data demonstrate that substance P at levels noted in the carcinoid syndrome induces significant jejunal secretion of water and electrolytes in the dog.<\/jats:p>","DOI":"10.1136\/gut.27.3.267","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"267-272","source":"Crossref","is-referenced-by-count":24,"title":["Substance P-induced intestinal secretion of water and electrolytes."],"prefix":"10.1136","volume":"27","author":[{"given":"D","family":"McFadden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Zinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"issue":"72","key":"ref_1","first-page":"74","article-title":"An unidentified depressor substance in certain tissue extracts","volume":"1931","author":"von Euler US; JH, Gaddum","unstructured":"von Euler US, Gaddum JH. An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 1931; 72: 74-87.","journal-title":"J Physiol (Lond)"},{"key":"ref_2","first-page":"85","volume":"35","author":"P, Pernow B.Substance","year":"1983","unstructured":"Pernow B. Substance P. Pharmacol Rev 1983; 35: 85-119.","journal-title":"Pharmacol Rev"},{"key":"ref_3","first-page":"147","article-title":"Substance P in the gut. An immunochemical and immunohistochemical study of its distribution and development","volume-title":"Nobel symposium 37","author":"Sundler, R.; Hakason, R.; Larsson, L.I.; Brodin, E.; Nilsson, G.","year":"1977","unstructured":"Sundler R, Hakason R, Larsson LI, Brodin E, Nilsson G. Substance P in the gut. An immunochemical and immunohistochemical study of its distribution and development. In: von Euler US, Pernow B, eds. Substance P, Nobel symposium 37. New York: Raven Press, 1977: 147-54."},{"key":"ref_4","first-page":"557","article-title":"Substance P containing nerve fibers are numerous in human but not","volume-title":"feline intestinal mucosa. Gastroenterology 1983; 85","author":"Brodin, E.; Sjolund, K.; Hakanson, R.; Sundler, F.","unstructured":"Brodin E, Sjolund K, Hakanson R, Sundler F. Substance P containing nerve fibers are numerous in human but not in feline intestinal mucosa. Gastroenterology 1983; 85: 557-64."},{"key":"ref_5","first-page":"49","article-title":"Tissue distribution of substance P-like immunoreactivity in dog, cat","volume-title":"Nobel symposium 37","author":"Nilsson, G.; Brodin, E.","year":"1977","unstructured":"Nilsson G, Brodin E. Tissue distribution of substance P-like immunoreactivity in dog, cat, rat, and mouse. In: von Euler US, Pernow B, eds. Substance P, Nobel symposium 37. New York: Raven Press, 1977: 49-54."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00490158","article-title":"Localization of substance P like immunoreactivity in mouse gut","volume":"43","author":"Nilsson, G.; Larsson, L.I.; Hakanson, R.; Brodin, E.; Pernow, B.; Sundler, F.","year":"1975","unstructured":"Nilsson G, Larsson LI, Hakanson R, Brodin E, Pernow B, Sundler F. Localization of substance P like immunoreactivity in mouse gut. Histochemistry 1975; 43: 97-9.","journal-title":"Histochemistry"},{"key":"ref_7","first-page":"175","article-title":"The effects of intravenous substance P infusion on hemodynamics and regional blood flow in conscious dogs","volume":"95","author":"Yeo, C.J.; Jaffe, B.M.; Zinner, M.J.","year":"1984","unstructured":"Yeo CJ, Jaffe BM, Zinner MJ. The effects of intravenous substance P infusion on hemodynamics and regional blood flow in conscious dogs. Surgery 1984; 95: 175-82.","journal-title":"Surgery"},{"key":"ref_8","article-title":"The effect of carcinoid levels of serotonin and substance P on hemodynamics","author":"Zinner, M.J.; Yeo, C.J.; Jaffe, B.M.","year":"1984","unstructured":"Zinner MJ, Yeo CJ, Jaffe BM. The effect of carcinoid levels of serotonin and substance P on hemodynamics. Ann Surg 1984; 199: 197-204.","journal-title":"Ann Surg"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/endo-102-2-393","article-title":"Effects of substance P and neurotensin infused intrapancreatically on glucagon and insulin secretion","volume":"102","author":"Kaneto, A.; Kaneto, T.; Kajinuma, H.; Kosaka, K.","year":"1978","unstructured":"Kaneto A, Kaneto T, Kajinuma H, Kosaka K. Effects of substance P and neurotensin infused intrapancreatically on glucagon and insulin secretion. Endocrinology 1978; 102: 393-400.","journal-title":"Endocrinology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/0024-3205(79)90533-2","article-title":"Role of substance P in water homeostasis","volume":"24","author":"Gullner, H.G.; Campbell, W.B.; Pettinger, W.A.","year":"1979","unstructured":"Gullner HG, Campbell WB, Pettinger WA. Role of substance P in water homeostasis. Life Sci 1979; 24: 2351-60.","journal-title":"Life Sci"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0016-5085(78)90802-8","article-title":"Effect of substance P on intestinal muscle","volume":"74","author":"Yau, W.","year":"1978","unstructured":"Yau W. Effect of substance P on intestinal muscle. Gastroenterology 1978; 74: 228-31.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"667","article-title":"Effects of substance P and somatostatin on choleresis in anesthetized dogs","volume":"147","author":"Magnusson, I.; Thulin, L.","year":"1981","unstructured":"Magnusson I, Thulin L. Effects of substance P and somatostatin on choleresis in anesthetized dogs. Acta Chir Scand 1981; 147: 667-71.","journal-title":"Acta Chir Scand"},{"key":"ref_13","first-page":"74","article-title":"Effect of substance P and its C-terminal hexapeptide on gastric and pancreatic secretion in the dog","volume":"241","author":"Konturek, S.J.; Jaworek, J.; Tasler, J.; Cieszkowski, M.; Pawlik, W.","year":"1981","unstructured":"Konturek SJ, Jaworek J, Tasler J, Cieszkowski M, Pawlik W. Effect of substance P and its C-terminal hexapeptide on gastric and pancreatic secretion in the dog. Am J Physiol 1981; 241: G74-81.","journal-title":"Am J Physiol"},{"key":"ref_14","first-page":"89","article-title":"Effects of calcitonin and substance P on the transport of Ca, Na, and Cl across rat","volume-title":"ileum in vitro. Gastroenterology 1977; 73","author":"Walling, M.W.; Brasitus, T.A.; Kimberg, D.V.","unstructured":"Walling MW, Brasitus TA, Kimberg DV. Effects of calcitonin and substance P on the transport of Ca, Na, and Cl across rat ileum in vitro. Gastroenterology 1977; 73: 89-94."},{"key":"ref_15","first-page":"456","article-title":"Neurohumoral control of ileal electrolyte transport. II. Neurotensin and substance P","volume":"220","author":"Kachur, J.F.; Miller, R.F.; Field, M.; Rivier, J.","year":"1982","unstructured":"Kachur JF, Miller RF, Field M, Rivier J. Neurohumoral control of ileal electrolyte transport. II. Neurotensin and substance P. J Pharmacol EYp Ther 1982; 220: 456-63.","journal-title":"J Pharmacol EYp Ther"},{"issue":"1979","key":"ref_16","first-page":"19","article-title":"and enteroglucagon-like immunoreactivity in argentaffin and argyrophil midgut carcinoid tumors","volume":"14","author":"Wilander, E.; Grimelius, L.; Portela-Gomes, G.","unstructured":"Wilander E, Grimelius L, Portela-Gomes G, et al. Substance P and enteroglucagon-like immunoreactivity in argentaffin and argyrophil midgut carcinoid tumors. Scand J Gastroenterol 14 1979; suppl 53: 19-25.","journal-title":"Scand J Gastroenterol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02939369","article-title":"Substance P secretion by carcinoid tumors","volume":"147","author":"Skrabanek, P.; Cannon, D.; Kirrane, J.; Powell, D.","year":"1978","unstructured":"Skrabanek P, Cannon D, Kirrane J, Powell D. Substance P secretion by carcinoid tumors. Irish J Med Sci 1978; 147: 47-9.","journal-title":"Irish J Med Sci"},{"key":"ref_18","first-page":"463","article-title":"Effect of serotonin on active electrolyte transport in rabbit ileum, gallbladder, and colon","volume":"239","author":"Donowitz, M.; Tai, Y.-H.; Asarkoff, N.","year":"1980","unstructured":"Donowitz M, Tai Y-H, Asarkoff N. Effect of serotonin on active electrolyte transport in rabbit ileum, gallbladder, and colon. Am J Physiol 1980; 239: G463-72.","journal-title":"Am J Physiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0016-5085(70)80090-7","article-title":"Total recovery studies of nonabsorbable indicators in the rat small intestine","volume":"58","author":"Miller, D.L.; Schedl, H.P.","year":"1970","unstructured":"Miller DL, Schedl HP. Total recovery studies of nonabsorbable indicators in the rat small intestine. Gastroenterology 1970; 58: 40-6.","journal-title":"Gastroenterology"},{"key":"ref_20","first-page":"378","article-title":"Radioimmunoassay measurement of substance P release following a meat meal","volume":"89","author":"Akande, B.; Reilly, P.; Modlin, I.M.; Jaffe, B.M.","year":"1981","unstructured":"Akande B, Reilly P, Modlin IM, Jaffe BM. Radioimmunoassay measurement of substance P release following a meat meal. Surgery 1981; 89: 378-83.","journal-title":"Surgery"},{"issue":"1","key":"ref_21","first-page":"48","article-title":"Substance P in carcinoid patients-tumor content and plasma levels","volume":"152","author":"Nobin, A.; Enson, P.; Sundler, F.","year":"1983","unstructured":"Nobin A, Enson P, Sundler F. Substance P in carcinoid patients-tumor content and plasma levels. Irish J Med Sci 1983; 152: suppl 1: 48-9.","journal-title":"Irish J Med Sci"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9610(85)80010-6","article-title":"The secretory effects of intravenous serotonin (5-hydroxytryptamine) on the proximal jejunum of the awake dog","volume":"149","author":"McFadden, D.W.; Jaffe, B.M.; Zinner, M.J.","year":"1985","unstructured":"McFadden DW, Jaffe BM, Zinner MJ. The secretory effects of intravenous serotonin (5-hydroxytryptamine) on the proximal jejunum of the awake dog. Am J Surgery 1985; 149: 60-4.","journal-title":"Am J Surgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/BF01070754","article-title":"Jejunal fluid and electrolyte secretion in the carcinoid syndrome","volume":"20","author":"Donowitz, M.; Binder, H.J.","year":"1975","unstructured":"Donowitz M, Binder HJ. Jejunal fluid and electrolyte secretion in the carcinoid syndrome. 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J Physiol (Lond) 1978; 278: 461-9.","journal-title":"J Physiol (Lond)"},{"key":"ref_36","volume-title":"Forthcoming Scientific Meetings of the British Society of Gastroenterology Lancaster 9-11","year":"1986","unstructured":"Forthcoming Scientific Meetings of the British Society of Gastroenterology Lancaster 9-11 April 1986"},{"key":"ref_37","article-title":"Cardiff 24-26","year":"1986","unstructured":"Cardiff 24-26 September 1986"},{"key":"ref_38","article-title":"London 15-18","year":"1987","unstructured":"London 15-18 September 1987"},{"key":"ref_39","article-title":"For details of registration please contact: The Administrative Secretary, British Society of Gastroenterology, 3 St Andrew's Place, Regent's Park, London NW1 4LB","unstructured":"For details of registration please contact: The Administrative Secretary, British Society of Gastroenterology, 3 St Andrew's Place, Regent's Park, London NW1 4LB."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.3.267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:30:40Z","timestamp":1757273440000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.3.267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1986,3,1]]},"published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1136\/gut.27.3.267"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.3.267","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}