{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:04:07Z","timestamp":1791198247406,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:p>Acetaminophen has been proposed as an agent which protects the gastric mucosa against damage induced by aspirin and other non-steroidal anti-inflammatory agents. In order to evaluate this proposal further, 45 normal human volunteers were divided into three groups (n = 15); group one received ibuprofen 2400 mg daily (600 mg qid); group two received acetaminophen 3900 mg daily (975 mg qid) and group three received both drugs at the same dosages. There was no significant difference in the mucosal injury scores noted at endoscopy between the ibuprofen and the ibuprofen-acetaminophen group. The acetaminophen group had virtually no observed mucosal injury and this was statistically significant in comparison with the other groups (p less than 0.01). We conclude that contrary to previously reported studies using single doses of aspirin, acetaminophen failed to decrease the mucosal injury seen with ibuprofen when given for a period of seven days in combination with acetaminophen.<\/jats:p>","DOI":"10.1136\/gut.27.4.440","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"440-443","source":"Crossref","is-referenced-by-count":18,"title":["Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen."],"prefix":"10.1136","volume":"27","author":[{"given":"F L","family":"Lanza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G L","family":"Royer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Rack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Seckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0016-5107(75)73812-9","article-title":"An endoscopic evaluation of the effects of nonsteroidal antiinflammatory drugs on the gastric mucosa","volume":"21","author":"Lanza, F.L.; Royer, G.L.; Nelson, R.","year":"1975","unstructured":"Lanza FL, Royer GL, Nelson R. An endoscopic evaluation of the effects of nonsteroidal antiinflammatory drugs on the gastric mucosa. Gastrointest Endosc 1975; 21: 103-5.","journal-title":"Gastrointest Endosc"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/BF01324896","article-title":"The effects of ibuprofen, indomethacin, aspirin, naproxen and placebo on the gastric mucosa of normal volunteers. A gastroscopic and photographic study","volume":"24","year":"1979","unstructured":"Lanza FL, Royer GL, Nelson RS, Chen 1T, Seckman CE, Rack MF. The effects of ibuprofen, indomethacin, aspirin, naproxen and placebo on the gastric mucosa of normal volunteers. A gastroscopic and photographic study. 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Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med 1979; 91: 517-20.","journal-title":"Ann Intern Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1056\/NEJM198007173030305","article-title":"Endoscopic evaluation of the effects of aspirin, buffered aspirin and enteric-coated aspirin on gastric and duodenal mucosa","volume":"303","author":"Lanza, F.L.; Royer, G.L.; Nelson, R.S.","year":"1980","unstructured":"Lanza FL, Royer GL, Nelson RS. Endoscopic evaluation of the effects of aspirin, buffered aspirin and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980; 303: 136-8.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/j.1552-4604.1984.tb02770.x","article-title":"A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of healthy volunteers","volume":"24","author":"Lanza, F.L.; Nelson, R.S.; Rack, M.F.","year":"1984","unstructured":"Lanza FL, Nelson RS, Rack MF. A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of healthy volunteers. J Clin Pharm 1984; 24: 89-95.","journal-title":"J Clin Pharm"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.7326\/0003-4819-91-6-877","volume":"91","author":"Ibuprofen, Kantor S.","year":"1979","unstructured":"Kantor S. Ibuprofen. 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