{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:42:47Z","timestamp":1765082567585,"version":"3.46.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>Basal and pentagastrin stimulated gastric secretion was measured in seven patients with duodenal, and six with gastric ulcers before and after four weeks' treatment with colloidal bismuth subcitrate (as De-Nol), one tablet four times a day. Each duodenal and all but one of the gastric ulcers healed. After De-Nol there were no significant changes in basal, or pentagastrin stimulated volume, acid output, or primary parietal component. There were marked decreases in basal (duodenal ulcer -25%; gastric ulcer -16%) and pentagastrin stimulated total pepsin outputs, (duodenal ulcer -42%, gastric ulcer -36%). There were insignificant decreases in basal output of mucus, but postpentagastrin stimulated mucus output was significantly inhibited (p less than 0.05) in patients with duodenal (-16%) and with gastric ulcer (-27%). The drop in gastric proteolysis after De-Nol is unlikely to be because of the healing of the ulcers and is more likely to be because of the drug. The ulcer healing efficacy of De-Nol may be related to this decline in the proteolytic action of gastric juice, but is unlikely to be because of a quantitative change in mucus, or in acid secretion.<\/jats:p>","DOI":"10.1136\/gut.27.5.486","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"486-490","source":"Crossref","is-referenced-by-count":38,"title":["Acid, pepsin, and mucus secretion in patients with gastric and duodenal ulcer before and after colloidal bismuth subcitrate (De-Nol)."],"prefix":"10.1136","volume":"27","author":[{"given":"J H","family":"Baron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Batten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sidebotham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"issue":"17","key":"ref_1","article-title":"De-Nol in the treatment of peptic ulcer","volume":"1982","author":"Tytgat, G.N.J.","unstructured":"Tytgat GNJ, Paul ZM, eds. De-Nol in the treatment of peptic ulcer. Scand J Gastroenterol 1982; 17: suppl 80.","journal-title":"Scand J Gastroenterol"},{"key":"ref_2","article-title":"Perspectives in duodenal ulcer Welwyn Garden","author":"Bardhan, K.D.","year":"1981","unstructured":"Bardhan KD. Perspectives in duodenal ulcer Welwyn Garden City: Smith Kline & French, 1981."},{"issue":"3","key":"ref_3","first-page":"537","article-title":"Note sur l'action myxogene de quelques sels de bismuth au niveau de l'estomac","volume":"1908","author":"Surmont, H.; Dubus, A.","unstructured":"Surmont H, Dubus A. Note sur l'action myxogene de quelques sels de bismuth au niveau de l'estomac. Arch Fr Mal App Dig 1908; 3: 537-9.","journal-title":"Arch Fr Mal App Dig"},{"key":"ref_4","first-page":"701","article-title":"Recherches experimentales sur le mode d'action du pansement au bismuth dans les affections de l'estomac. Arch Fr Mal App Dig 1908; 2","author":"Surmont, H.; Dubus, A.","unstructured":"Surmont H, Dubus A. Recherches experimentales sur le mode d'action du pansement au bismuth dans les affections de l'estomac. Arch Fr Mal App Dig 1908; 2: 701-12."},{"key":"ref_5","first-page":"112","article-title":"Mucus secretion in gastric ulcer patients treated with tripotassium dicitrate bismuthate (De-Nol)","volume":"37","author":"Hollanders, D.; Morrissey, S.M.; Mehta, J.","year":"1983","unstructured":"Hollanders D, Morrissey SM, Mehta J. Mucus secretion in gastric ulcer patients treated with tripotassium dicitrate bismuthate (De-Nol). Br J Clin Pract 1983; 37: 112-4.","journal-title":"Br J Clin Pract"},{"key":"ref_6","first-page":"48","article-title":"Does the duodenal cell ever return to normal? A comparison between treatment with cimetidine and De-Nol","volume":"54","author":"Moshal, M.G.; Gregory, M.A.; Pillay, C.; Spitaels, J.M.","year":"1979","unstructured":"Moshal MG, Gregory MA, Pillay C, Spitaels JM. Does the duodenal cell ever return to normal? A comparison between treatment with cimetidine and De-Nol. Scand J Gastroenterol 1979; suppl 54: 48-51.","journal-title":"Scand J Gastroenterol"},{"issue":"17","key":"ref_7","first-page":"11","article-title":"Pharmacological properties of colloidal bismuth subcitrate (CBS, DE-NOL (R))","volume":"1982","author":"Wieriks, J.; Hespe, W.; Jaitly, K.D.; Koekkoek, P.H.; Lavy, U.","unstructured":"Wieriks J, Hespe W, Jaitly KD, Koekkoek PH, Lavy U. Pharmacological properties of colloidal bismuth subcitrate (CBS, DE-NOL (R)). Scand J Gastroenterol 1982; 17: suppl 80, 11-16.","journal-title":"Scand J Gastroenterol"},{"key":"ref_8","article-title":"Clinical tests of gastric secretion. History, methodology and interpretation","author":"Baron, J.H.","year":"1979","unstructured":"Baron JH. Clinical tests of gastric secretion. History, methodology and interpretation. London: Macmillan, 1978: New York: Oxford University Press, 1979."},{"key":"ref_9","first-page":"15","article-title":"Le dosage automatique de l'activite proteolytique du suc gastrique","volume":"1","author":"Vatier, J.; Cheret, A.M.; Bonfils, S.","year":"1968","unstructured":"Vatier J, Cheret AM, Bonfils S. Le dosage automatique de l'activite proteolytique du suc gastrique. Biol Gastroenterol 1968; 1: 15-29.","journal-title":"Biol Gastroenterol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1136\/gut.15.11.880","article-title":"Duodenal reflux during insulin-stimulated secretion","volume":"15","author":"Faber, R.G.; Russell, R.C.G.; Royston, C.M.S.; Whitfield, P.; Hobsley, M.","year":"1974","unstructured":"Faber RG, Russell RCG, Royston CMS, Whitfield P, Hobsley M. Duodenal reflux during insulin-stimulated secretion. Gut 1974; 15: 880-4.","journal-title":"Gut"},{"key":"ref_11","first-page":"212","article-title":"A basal-insulin-pentagastrin gastric secretion test. Appendix to Baron JH. Clinical tests ofgastric secretion. History, methodology and interpretation","author":"McCloy, R.F.","year":"1978","unstructured":"McCloy RF. A basal-insulin-pentagastrin gastric secretion test. Appendix to Baron JH. Clinical tests ofgastric secretion. History, methodology and interpretation London: Macmillan, 1978: 212-7."},{"issue":"65","key":"ref_12","first-page":"13","article-title":"Effect of tripotassium dicitrobismuthate (De-Nol) upon individual human pepsins","volume":"63","author":"Roberts, N.B.; Taylor, W.H.","year":"1982","unstructured":"Roberts NB, Taylor WH. Effect of tripotassium dicitrobismuthate (De-Nol) upon individual human pepsins. Clin Sci 1982; 63: 65P. 13 Brouwers JRBJ. Pathofysiologe en Farmacotherapie van peptische afwijkingen. Amsterdam University, Thesis 1981: 126-33 14 Baron JH. Effect of carbenoxolone sodium on human gastric acid secretion. Gut 1977; 18: 721-2.","journal-title":"Clin Sci; Pathofysiologe en Farmacotherapie van peptische afwijkingen"},{"key":"ref_13","first-page":"448","article-title":"The action of carbenoxolone on enzymes, with special reference to the pepsins and their secretion","volume":"46","author":"Roberts, N.B.; Walker, V.; Etherington, D.J.; Baron, J.H.; McConnell, R.B.; Taylor, W.H.","year":"1983","unstructured":"Roberts NB, Walker V, Etherington DJ, Baron JH, McConnell RB, Taylor WH. The action of carbenoxolone on enzymes, with special reference to the pepsins and their secretion. Acta Gastroenterol Belg 1983; 46: 448-58.","journal-title":"Acta Gastroenterol Belg"},{"key":"ref_14","first-page":"1018","article-title":"shamfeed and pentagastrin-stimulated gastric acid, pepsin and electrolytes after omeprazole 20 and 40 mg daily","volume-title":"Gut","volume":"26","author":"Thompson, J.N.; Barr, J.A.; Collier, N.","year":"1985","unstructured":"Thompson JN, Barr JA, Collier N et al. Basal, shamfeed and pentagastrin-stimulated gastric acid, pepsin and electrolytes after omeprazole 20 and 40 mg daily. Gut 1985; 26: 1018-24."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.5.486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:19:12Z","timestamp":1765077552000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.5.486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1986,5,1]]},"published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1136\/gut.27.5.486"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.5.486","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}