{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:34:46Z","timestamp":1792157686379,"version":"4.4.0"},"reference-count":11,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>Modern narcotic analgesic drugs, such as tramadol, pentazocine, and buprenorphine share similarities of molecular structure with morphine which is widely believed to cause spasm of the bile duct sphincter and so impede bile flow. This study assessed the effects of intravenously administered analgesics on bile duct sphincter motor activity measured by ERCP manometry. Ten minutes after pentazocine injection the duration of contractions and baseline pressure of the bile duct sphincter rose from 6.2 +\/- 0.2 to 8.2 +\/- 0.27 s and from 5.1 +\/- 0.6 to 8.8 +\/- 0.4 mmHg respectively. Tramadol, buprenorphine and saline showed no such effect. These data indicated that the effects of such drugs on bile duct sphincter function can be safely assessed by ERCP manometry and that pentazocine adversely affects the bile duct sphincter, whilst tramadol and buprenorphine do not. We consider therefore that pentazocine is not the premedication of first choice for endoscopic procedures involving the sphincter of Oddi and should also be avoided in patients with pancreatic and biliary disorders.<\/jats:p>","DOI":"10.1136\/gut.27.5.567","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"567-569","source":"Crossref","is-referenced-by-count":72,"title":["Effect of modern analgesic drugs (tramadol, pentazocine, and buprenorphine) on the bile duct sphincter in man."],"prefix":"10.1136","volume":"27","author":[{"given":"M","family":"Staritz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Poralla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K H","family":"Meyer Zum B\u00fcschenfelde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"key":"ref_1","first-page":"417","article-title":"A comparative study of pentazocine and meperidine on the biliary passage pressure","volume":"58","author":"Greenstein, A.J.; Kaynan, A.; Singer, A.; Dreiling, D.A.","year":"1972","unstructured":"Greenstein AJ, Kaynan A, Singer A, Dreiling DA. A comparative study of pentazocine and meperidine on the biliary passage pressure. Am J Gastroenterol 1972; 58: 417-27.","journal-title":"Am J Gastroenterol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1399-6576.1981.tb01617.x","article-title":"The effect of Buprenorphine and Oxycodone on the intracholedochal passage pressure","volume":"25","author":"Tigerstedt, I.; Turunen, M.; Tammisto, T.; Hastback, J.","year":"1981","unstructured":"Tigerstedt I, Turunen M, Tammisto T, Hastback J. The effect of Buprenorphine and Oxycodone on the intracholedochal passage pressure. Acta Anaesthesiol Scand 1981; 25: 99-102.","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/gut.8.3.296","article-title":"Action of various analgesic drugs on the human common bile duct","volume":"8","author":"Hopton, D.S.; Torrance, H.B.","year":"1967","unstructured":"Hopton DS, Torrance HB. Action of various analgesic drugs on the human common bile duct. Gut 1967; 8: 296-300.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000199181","article-title":"Effect of the artificially elevated common bile duct pressure on the function of the papilla Vateri","volume":"31","author":"Staritz, M.; Ewe, K.; Meyer zum Buschenfelde, K.H.","year":"1985","unstructured":"Staritz M, Ewe K, Meyer zum Buschenfelde KH. Effect of the artificially elevated common bile duct pressure on the function of the papilla Vateri. Digestion 1985; 31: 61-6.","journal-title":"Digestion"},{"key":"ref_5","first-page":"195","article-title":"Effect of glyceryl trinitrate on the sphincter of Oddi motility and baseline pressure","volume":"26","author":"Staritz, M.; Poralla, T.; Ewe, K.; Meyer zum Buschenfelde, K.H.","year":"1985","unstructured":"Staritz M, Poralla T, Ewe K, Meyer zum Buschenfelde KH. Effect of glyceryl trinitrate on the sphincter of Oddi motility and baseline pressure. Gut 1985; 26: 195-7.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/gut.24.1.20","article-title":"Effects of ethanol on the sphincter of Oddi: An endoscopic manometric study","volume":"24","author":"Viceconte, G.","year":"1983","unstructured":"Viceconte G. Effects of ethanol on the sphincter of Oddi: An endoscopic manometric study. Gut 1983; 24: 24-7.","journal-title":"Gut"},{"key":"ref_7","first-page":"126","article-title":"Manometric evaluation of the papilla of Vater. Gastrointest Endosc","volume":"21","author":"Nebel, O.T.","year":"1975","unstructured":"Nebel OT. Manometric evaluation of the papilla of Vater. Gastrointest Endosc 1975; 21: 126-8."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archsurg.1968.01330240015004","article-title":"Bile flow mechanisms in man","volume":"96","author":"Ono, K.; Watanabe, N.; Suzuki, K.; Tsichida, H.; Sugiyama, Y.; Abo, M.","year":"1968","unstructured":"Ono K, Watanabe N, Suzuki K, Tsichida H, Sugiyama Y, Abo M. Bile flow mechanisms in man. Arch Surg 1968; 96: 869-74.","journal-title":"Arch Surg"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-2007-1021507","article-title":"Endoscopic papillary dilation (EPD) for the treatment of common bile duct stones and papillary stenosis","volume":"15","author":"Staritz, M.; Ewe, K.; Meyer zum Buschenfelde, K.H.","year":"1983","unstructured":"Staritz M, Ewe K, Meyer zum Buschenfelde KH. Endoscopic papillary dilation (EPD) for the treatment of common bile duct stones and papillary stenosis. Endoscopy 1983; 15: 197-8.","journal-title":"Endoscopy"},{"key":"ref_10","first-page":"1807","article-title":"Endoscopic removal of common bile duct stones through the intact papilla following","volume-title":"medical sphincter dilation. Gastroenterology 1985; 88","author":"Staritz, M.; Poralla, T.; Dormeyer, H.H.; Meyer zum Buschenfelde, K.H.","unstructured":"Staritz M, Poralla T, Dormeyer HH, Meyer zum Buschenfelde KH. Endoscopic removal of common bile duct stones through the intact papilla following medical sphincter dilation. Gastroenterology 1985; 88: 1807-11"},{"key":"ref_11","first-page":"168","article-title":"Pharmacological pressure reduction in the human common bile duct","volume-title":"Z Gastroenterol","volume":"21","author":"Brandstadter, G.","year":"1983","unstructured":"Brandstadter G. Pharmacological pressure reduction in the human common bile duct. Z Gastroenterol 1983; 21: 168-74."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.5.567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:13:03Z","timestamp":1757272383000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.5.567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1986,5,1]]},"published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1136\/gut.27.5.567"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.5.567","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}