{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:28:08Z","timestamp":1771867688822,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in 81 jejunal biopsies. Thirty one were from patients with coeliac disease or dermatitis herpetiformis, and many of these, from treated patients, were histologically normal; 40 were from patients with other diagnoses, selected to include biopsies with a high IEL count (greater than 40 IEL per 100 enterocytes) but normal villi. Three coeliacs and 10 dermatitis herpetiformis patients had an IEL count of less than 40, and no IEL mitoses were found in these biopsies. Two dermatitis herpetiformis patients had IEL counts of 43.7% and 43.9%, with no IEL mitoses, but in all other coeliac and dermatitis herpetiformis biopsies high IEL counts were associated with IEL mitotic indices between 0.05% and 1.77%. In the non-coeliac, non-dermatitis herpetiformis group, no IEL mitoses were found in the 22 biopsies with IEL count less than 43%. In the others, IEL counts ranged from 44.8% to 127.0%, and IEL mitoses were present, with mitotic indices ranging from 0.06% to 0.49%. This work shows that IEL mitosis in a jejunal biopsy is not specific for coeliac disease, but occurs whenever there is an increased density of IEL within the villus epithelium.<\/jats:p>","DOI":"10.1136\/gut.27.6.675","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"675-679","source":"Crossref","is-referenced-by-count":17,"title":["Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis."],"prefix":"10.1136","volume":"27","author":[{"given":"A","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/gut.18.11.921","article-title":"Intraepithelial lymphocytes of the small intestine","volume":"18","author":"Ferguson, A.","year":"1977","unstructured":"Ferguson A. Intraepithelial lymphocytes of the small intestine. Gut 1977; 18: 921-37.","journal-title":"Gut"},{"key":"ref_2","first-page":"481","article-title":"Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue","volume":"79","author":"Marsh, M.N.","year":"1980","unstructured":"Marsh MN. Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue. Gastroenterology 1980; 79: 481-92.","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/jcp.35.5.517","article-title":"Studies of intestinal lymphoid tissue. IV. The predictive value of raised mitotic indices among jejunal epithelial lymphocytes in the diagnosis of gluten-sensitive enteropathy","volume":"35","author":"Marsh, M.N.","year":"1982","unstructured":"Marsh MN. Studies of intestinal lymphoid tissue. IV. The predictive value of raised mitotic indices among jejunal epithelial lymphocytes in the diagnosis of gluten-sensitive enteropathy. J Clin Pathol 1982; 35: 517-25.","journal-title":"J Clin Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jcp.36.2.149","article-title":"Studies of intestinal lymphoid tissue. VI. Proliferative response of small intestinal epithelial lymphocytes distinguishes glutenfrom nongluten-induced enteropathy","volume":"36","author":"Marsh, M.N.; Haeney, M.R.","year":"1983","unstructured":"Marsh MN, Haeney MR. Studies of intestinal lymphoid tissue. VI. Proliferative response of small intestinal epithelial lymphocytes distinguishes glutenfrom nongluten-induced enteropathy. J Clin Pathol 1983; 36: 149-60.","journal-title":"J Clin Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.12.12.988","article-title":"Quantitation of intraepithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson A, Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut 1971; 12: 988-94.","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/gut.25.2.158","article-title":"Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased?","volume":"25","author":"Corazza, G.R.; Frazzoni, M.; Gasbarrini, G.","year":"1984","unstructured":"Corazza GR, Frazzoni M, Gasbarrini G. Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased? Gut 1984; 25: 158-62.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1136\/gut.25.11.1241","article-title":"The cellobiose\/ mannitol sugar permeability test complements biopsy histopathology in clinical investigation of the jejunum","volume":"25","author":"Strobel, S.; Brydon, W.G.; Ferguson, A.","year":"1984","unstructured":"Strobel S, Brydon WG, Ferguson A. The cellobiose\/ mannitol sugar permeability test complements biopsy histopathology in clinical investigation of the jejunum. Gut 1984; 25: 1241-6.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0016-5085(82)80338-7","article-title":"Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine","volume":"83","author":"AMcI, Mowat; A, Ferguson","year":"1982","unstructured":"Mowat AMcI, Ferguson A. Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine. Gastroenterology 1982; 83: 417-23.","journal-title":"Gastroenterology"},{"key":"ref_9","article-title":"Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice","author":"Strobel, S.; Ferguson, A.","unstructured":"Strobel S, Ferguson A. Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice. Gut In press."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00007890-198109000-00011","article-title":"Hypersensitivity reaction in the small intestine. 6. Pathogenesis of the graftversus-host reaction in the small intestinal mucosa","volume":"32","author":"AMcI, Mowat; A, Ferguson","year":"1981","unstructured":"Mowat AMcI, Ferguson A. Hypersensitivity reaction in the small intestine. 6. Pathogenesis of the graftversus-host reaction in the small intestinal mucosa. Transplantation 1981; 32: 238-43.","journal-title":"Transplantation"},{"key":"ref_11","first-page":"637","article-title":"Gluten intolerance (coeliac disease)","volume":"53","author":"Ferguson, A.; Ziegler, K.; Strobel, S.","year":"1984","unstructured":"Ferguson A, Ziegler K, Strobel S. Gluten intolerance (coeliac disease). Ann Allergy 1984; 53: 637-42.","journal-title":"Ann Allergy"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.6.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:19:50Z","timestamp":1757272790000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.6.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1986,6,1]]},"published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1136\/gut.27.6.675"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.6.675","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}