{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:55:29Z","timestamp":1765079729340,"version":"3.46.0"},"reference-count":44,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>A case of alpha chain disease, involving the stomach only, is reported in an Algerian man suffering from epigastric pains. Upper digestive tract fibreoptic endoscopy showed two antral ulcers and an ulcerative gastritis pattern, which promptly disappeared with cimetidine treatment. Antral biopsies at a distance from the ulcers, but not of the ulcer crater itself, disclosed a dense infiltration of antral lamina propria by mature or sometimes atypical plasma cells. On transmural surgical antral biopsy, the infiltrate spread to the superficial part of the submucosa. No other localisation of the disease was found in spite of multiple biopsies obtained by endoscopy, with a peroral capsule and during staging laparotomy. The alpha chain disease protein was absent from serum and urine, but found in the gastric juice and in the cytoplasma of the cellular infiltrate (alpha 1 subclass). A complete clinical, endoscopic, histological and immunological remission was observed after a six months' course of oral tetracycline.<\/jats:p>","DOI":"10.1136\/gut.27.6.719","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"719-725","source":"Crossref","is-referenced-by-count":9,"title":["Gastric form of alpha chain disease."],"prefix":"10.1136","volume":"27","author":[{"given":"J","family":"Coulbois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Galian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Galian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Couteaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Danon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rambaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000196874","article-title":"Clinicopathological study of a patient with \"mediterranean\" type of abdominal lymphoma and new type of IgA abnormality (\"Alpha-chain disease\")","volume":"1","author":"Rambaud, J.C.; Bognel, C.; Prost, A.","year":"1968","unstructured":"Rambaud JC, Bognel C, Prost A et al. 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Remission complete clinique, histologique et immunologique d'un cas de maladie des chaines alpha traite par antibiotherapie orale. Gastroenterol Clin Biol 1978; 2: 49-61.","journal-title":"Gastroenterol Clin Biol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/1097-0142(19820515)49:10<2025::AID-CNCR2820491014>3.0.CO;2-X","article-title":"Gastric plasmocytoma. An immunologic and immunohistochemical study","volume":"49","author":"Nakanishi, I.; Kajikana, K.; Migita, S.; Mai, M.; Akimoto, R.; Mura, T.","year":"1982","unstructured":"Nakanishi I, Kajikana K, Migita S, Mai M, Akimoto R, Mura T. Gastric plasmocytoma. An immunologic and immunohistochemical study. 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Amiens: These de Medecine, 1976."},{"key":"ref_23","first-page":"365","article-title":"Invasion gastrica en la macroglobulinemia de Waldenstrom","volume":"157","author":"de Quiros C, Garcia Bernaldo; EG, Diego Gonzalez; I, Riesgo Gonzalez; G, Ocio Achaerandio; JA, Mosquera Pestana","year":"1980","unstructured":"Garcia Bernaldo de Quiros C, Diego Gonzalez EG, Riesgo Gonzalez I, Ocio Achaerandio G, Mosquera Pestana JA. Invasion gastrica en la macroglobulinemia de Waldenstrom. Rev Clin Esp 1980; 157: 365-9.","journal-title":"Rev Clin Esp"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1182\/blood.V39.6.874.874","article-title":"Macroglobulinemia: an analysis for 40 patients","volume":"39","author":"McKenzie, M.R.; Fudenberg, H.H.","year":"1972","unstructured":"McKenzie MR, Fudenberg HH. Macroglobulinemia: an analysis for 40 patients. Blood 1972; 39: 874-89.","journal-title":"Blood"},{"key":"ref_25","first-page":"311","article-title":"Les formes gastriques de la maladie de Waldenstrom","volume":"8","author":"Frojet, J.; Pergola, F.; Cachin, M.","year":"1972","unstructured":"Frojet J, Pergola F, Cachin M. Les formes gastriques de la maladie de Waldenstrom. Ann Gastroenterol Hepatol 1972; 8: 311-6."},{"key":"ref_26","first-page":"303","article-title":"Localisations gastroduodenales de la maladie de Waldenstrom","volume":"1","author":"Cristau, P.; Gauthier, D.; Molinie, C.; Ule, H.; Antoine, H.; Laverdan, C.","year":"1972","unstructured":"Cristau P, Gauthier D, Molinie C, Ule H, Antoine H, Laverdan C. Localisations gastroduodenales de la maladie de Waldenstrom. Med Chir Dig 1972; 1: 303-6.","journal-title":"Med Chir Dig"},{"key":"ref_27","article-title":"Les localisations digestives de la macroglobulinemie de Waldenstrom","author":"Galmiche, J.P.","year":"1974","unstructured":"Galmiche JP. Les localisations digestives de la macroglobulinemie de Waldenstrom. Rouen: These de Medecine, 1974."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/archinte.1978.03630320083030","article-title":"Gamma heavy chain disease seen initially as gastric neoplasm","volume":"138","author":"Papac, R.J.; Rosenstein, R.W.; Richards, F.; Yesner, R.","year":"1978","unstructured":"Papac RJ, Rosenstein RW, Richards F, Yesner R. Gamma heavy chain disease seen initially as gastric neoplasm. Arch Intern Med 1978; 138: 1151-3.","journal-title":"Arch Intern Med"},{"key":"ref_29","first-page":"897","article-title":"Enteropathie exudative et macroglobulinemie. Presentation d'un cas suivi depuis","volume":"2","author":"Roge, J.; Marche, C.; Camilleri, J.P.; Druet, P.; SilvereanoRoge, F.; Vernier, G.","year":"1978","unstructured":"Roge J, Marche C, Camilleri JP, Druet P, SilvereanoRoge F, Vernier G. Enteropathie exudative et macroglobulinemie. 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Antibody expression in secretions following gastro-intestinal stimulations","volume":"9","author":"Montgomery, P.C.; Lemaitre-Coelho, I.M.; Vaerman, J.P.","year":"1980","unstructured":"Montgomery PC, Lemaitre-Coelho IM, Vaerman JP. A common mucosal immune system. Antibody expression in secretions following gastro-intestinal stimulations. Immunol Commun 1980; 9: 705-13.","journal-title":"Immunol Commun"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.4049\/jimmunol.128.3.1311","article-title":"Determinants of the localization, magnitude, and duration of a specific mucosal IgA plasma cell response in enterically immunized rats","volume":"128","author":"Pierce, N.; Gray, W.C.","year":"1982","unstructured":"Pierce N, Gray WC. Determinants of the localization, magnitude, and duration of a specific mucosal IgA plasma cell response in enterically immunized rats. 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