{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:01:00Z","timestamp":1768903260617,"version":"3.49.0"},"reference-count":8,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>Two hundred and seventy five patients with Crohn's disease from five countries were interviewed. Each patient was matched with a control of the same age. Of the 275 women with Crohn's disease 224 had been married at some time compared with 208 controls. The mean age at marriage was 23 years. Diagnosis of Crohn's disease was made five years later and the survey was conducted on average 16 years after marriage. Cases and controls had a similar obstetric study before diagnosis. After diagnosis there was a significant reduction in the number of children born to patients (0.4) compared with controls (0.7). Crohn's disease did not increase the rate of miscarriage or Caesarean section but prematurity was more common in patients (16%) than controls (7%). The site of disease at diagnosis did not affect these findings. Medical advice against pregnancy may be partly responsible for this reduction in fertility, but patients practised contraception less than controls and a significantly greater proportion of these (42%) failed to become pregnant compared with controls (28%). Crohn's disease results in subfertility.<\/jats:p>","DOI":"10.1136\/gut.27.7.821","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"821-825","source":"Crossref","is-referenced-by-count":142,"title":["European survey of fertility and pregnancy in women with Crohn's disease: a case control study by European collaborative group."],"prefix":"10.1136","volume":"27","author":[{"given":"J F","family":"Mayberry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I T","family":"Weterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(19)35807-X","article-title":"Regional ileitis complicating pregnancy","volume":"31","author":"Crohn, B.B.; Yarnis, H.; Korelitz, B.I.","year":"1956","unstructured":"Crohn BB, Yarnis H, Korelitz BI. Regional ileitis complicating pregnancy. Gastroenterology 1956; 31: 615-28.","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"4","article-title":"Family size and age at childbirth: trends and projections","volume":"33","author":"Werner, B.","year":"1983","unstructured":"Werner B. Family size and age at childbirth: trends and projections. Population Trends 1983; 33: 4-17.","journal-title":"Population Trends"},{"key":"ref_3","first-page":"39","article-title":"Worldwide variations in low birth weight","volume-title":"The epidemiology of prematurity. Baltimore-Munich: Urban and Schwarzenberg","author":"Boldman, R.; Reed, D.M.","year":"1977","unstructured":"Boldman R, Reed DM. Worldwide variations in low birth weight. In: Reed DM, Stanley FJ, eds. The epidemiology of prematurity. Baltimore-Munich: Urban and Schwarzenberg. 1977: 39-52."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/gut.25.1.52","article-title":"Crohn's disease and pregnancy","volume":"25","author":"Khosla, R.; Willoughby, C.P.; Jewell, D.P.","year":"1984","unstructured":"Khosla R, Willoughby CP, Jewell DP. Crohn's disease and pregnancy. Gut 1984; 25: 52-6.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01250985","article-title":"Morbus Crohn und Schwangerschaft","volume":"359","author":"Kreig, H.; Brunner, H.; Daniels, V.","year":"1983","unstructured":"Kreig H, Brunner H, Daniels V. Morbus Crohn und Schwangerschaft. Langenbecks Arch Chir, 1983; 359: 219-26.","journal-title":"Langenbecks Arch Chir"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/bmj.2.5701.76","article-title":"Pregnancy and Crohn's disease","volume":"2","author":"Fielding, J.F.; Cooke, W.T.","year":"1970","unstructured":"Fielding JF, Cooke WT. Pregnancy and Crohn's disease. Br Med J 1970; 2: 76-7.","journal-title":"Br Med J"},{"key":"ref_7","first-page":"550","volume":"3","author":"FT, De Dombal; IL, Burton; JC, Goligher","year":"1972","unstructured":"De Dombal FT, Burton IL, Goligher JC. Crohn's disease and pregnancy. Br Med J 1972; 3: 550-3.","journal-title":"Crohn's disease and pregnancy. Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00004836-198206000-00008","article-title":"Inflammatory bowel disease and pregnancy","volume":"4","author":"Vender, R.J.; Spiro, H.M.","year":"1982","unstructured":"Vender RJ, Spiro HM. Inflammatory bowel disease and pregnancy. J Clin Gastroenterol 1982; 4: 231-49.","journal-title":"J Clin Gastroenterol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.27.7.821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:22:05Z","timestamp":1765617725000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.27.7.821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1986,7,1]]},"published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1136\/gut.27.7.821"],"URL":"https:\/\/doi.org\/10.1136\/gut.27.7.821","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}